全文获取类型
收费全文 | 1953篇 |
免费 | 122篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 165篇 |
妇产科学 | 41篇 |
基础医学 | 201篇 |
口腔科学 | 49篇 |
临床医学 | 235篇 |
内科学 | 435篇 |
皮肤病学 | 24篇 |
神经病学 | 41篇 |
特种医学 | 475篇 |
外科学 | 131篇 |
综合类 | 78篇 |
预防医学 | 74篇 |
眼科学 | 14篇 |
药学 | 63篇 |
中国医学 | 3篇 |
肿瘤学 | 67篇 |
出版年
2022年 | 9篇 |
2021年 | 21篇 |
2020年 | 13篇 |
2019年 | 13篇 |
2018年 | 19篇 |
2017年 | 15篇 |
2016年 | 31篇 |
2015年 | 33篇 |
2014年 | 35篇 |
2013年 | 70篇 |
2012年 | 41篇 |
2011年 | 33篇 |
2010年 | 84篇 |
2009年 | 61篇 |
2008年 | 47篇 |
2007年 | 36篇 |
2006年 | 40篇 |
2005年 | 36篇 |
2004年 | 23篇 |
2003年 | 32篇 |
2002年 | 26篇 |
2001年 | 24篇 |
2000年 | 29篇 |
1999年 | 34篇 |
1998年 | 136篇 |
1997年 | 121篇 |
1996年 | 125篇 |
1995年 | 92篇 |
1994年 | 74篇 |
1993年 | 84篇 |
1992年 | 28篇 |
1991年 | 25篇 |
1990年 | 17篇 |
1989年 | 60篇 |
1988年 | 47篇 |
1987年 | 49篇 |
1986年 | 48篇 |
1985年 | 52篇 |
1984年 | 26篇 |
1983年 | 36篇 |
1982年 | 35篇 |
1981年 | 21篇 |
1980年 | 36篇 |
1979年 | 19篇 |
1978年 | 19篇 |
1977年 | 18篇 |
1976年 | 23篇 |
1975年 | 24篇 |
1968年 | 8篇 |
1925年 | 5篇 |
排序方式: 共有2097条查询结果,搜索用时 15 毫秒
91.
Sven Goetstouwers Dagmar Kempink Bertram The Denise Eygendaal Bart van Oirschot Christiaan JA van Bergen 《World journal of orthopedics》2022,13(1):1-10
Three-dimensional (3D) printing is a rapidly evolving and promising field to improve outcomes of orthopaedic surgery. The use of patient-specific 3D-printed models is specifically interesting in paediatric orthopaedic surgery, as limb deformity corrections often require an individual 3D treatment. In this editorial, various operative applications of 3D printing in paediatric orthopaedic surgery are discussed. The technical aspects and the imaging acquisition with computed tomography and magnetic resonance imaging are outlined. Next, there is a focus on the intraoperative applications of 3D printing during paediatric orthopaedic surgical procedures. An overview of various upper and lower limb deformities in paediatrics is given, in which 3D printing is already implemented, including post-traumatic forearm corrections and proximal femoral osteotomies. The use of patient-specific instrumentation (PSI) or guiding templates during the surgical procedure shows to be promising in reducing operation time, intraoperative haemorrhage and radiation exposure. Moreover, 3D-printed models for the use of PSI or patient-specific navigation templates are promising in improving the accuracy of complex limb deformity surgery in children. Lastly, the future of 3D printing in paediatric orthopaedics extends beyond the intraoperative applications; various other medical applications include 3D casting and prosthetic limb replacement. In conclusion, 3D printing opportunities are numerous, and the fast developments are exciting, but more evidence is required to prove its superiority over conventional paediatric orthopaedic surgery. 相似文献
92.
Barbara Uhl Katharina T Prochazka Karoline Fechter Katrin Pansy Hildegard T Greinix Peter Neumeister Alexander JA Deutsch 《World journal of gastrointestinal oncology》2022,14(1):153-162
Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT), also known as MALT lymphomas. These arise at a wide range of different extranodal sites, with most cases affecting the stomach, the lung, the ocular adnexa and the thyroid. The small intestine is involved in a lower percentage of cases. Lymphoma growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections (e.g., Helicobacter pylori or Chlamydia psittaci infections) or autoimmune conditions (e.g., Sjögren’s syndrome or Hashimoto thyroiditis). While these inflammatory processes trigger lymphoma cell proliferation and/or survival, they also shape the microenvironment. Thus, activated immune cells are actively recruited to the lymphoma, resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like cytokines. In addition, chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell growth. Recently, novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid malignancies. In this review, we aim to describe the composition of the microenvironment of MALT lymphoma, the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironment-targeting agents. 相似文献
93.
94.
Photodynamic therapy of gynecologic neoplasms after presensitization with hematoporphyrin derivative 总被引:2,自引:0,他引:2
Five patients with various gynecologic neoplasms were treated with photodynamic therapy using 630-nm light delivered from an argon dye laser system following the intravenous injection of hematoporphyrin derivative (HpD). A patient with multifocal squamous cell cancer of the vagina had no evidence of disease 15 months after her first photodynamic therapy treatment. Autopsy nine months after the first treatment of another patient with multifocal invasive cancer of the vagina and parametrium showed no evidence of tumor on the surface of the vagina. Eight months after treatment of an 8 X 12 cm area of Bowen's disease of the vulva and thigh, there was no evidence of disease. Vaginal bleeding from breast cancer metastatic to the endometrium was controlled by one treatment until the patient expired five months later from her disease. Adenocarcinoma metastatic to the vaginal cuff showed partial response when vaginectomy was performed five weeks after photodynamic therapy. 相似文献
95.
Cardiovascular effects at multi-detector row CT colonography compared with those at conventional endoscopy of the colon 总被引:4,自引:0,他引:4
Taylor SA Halligan S O'Donnell C Morley S Mistry H Saunders BP Vance M Bassett P Windsor A Stern Y Bethel H Atkin W Bartram CI 《Radiology》2003,229(3):782-790
PURPOSE: To compare the cardiovascular effects of computed tomographic (CT) colonography and conventional endoscopy in a group of patients undergoing both procedures. MATERIALS AND METHODS: A total of 144 patients underwent CT colonography followed by flexible sigmoidoscopy (40 patients) or colonoscopy (104 patients). Pulse, blood pressure, and oxygen saturation were measured before, during, and after the procedures. Forty patients also underwent continuous Holter electrocardiographic (ECG) monitoring. Periprocedural pain was assessed by using a handheld counting device. Outcome variables were assessed by using a combination of paired t testing and multilevel linear regression. RESULTS: When a spasmolytic was not used, CT colonography was associated with only a small increase in oxygen saturation (P =.03), while use of a spasmolytic caused an increase in pulse (mean increase, 19.9 beats per minute; P <.001) and diastolic blood pressure (mean increase, 5 mm Hg; P <.001). Compared with that at CT, oxygen saturation decreased significantly during and after colonoscopy and sigmoidoscopy (mean decrease after colonoscopy with sedation, 1.0%; P <.001). Systolic and diastolic blood pressure also decreased during and after colonoscopy (mean systolic decrease after colonoscopy with sedation, 16.6 mm Hg, P <.001; mean diastolic decrease after colonoscopy with sedation, 7.5 mm Hg, P <.001). Patients were 30.3 times more likely to develop bradycardia after endoscopy (95% CI: 2.65, 346; P =.006). Ventricular couplets were significantly higher at endoscopy than at CT in patients with a history of cardiac disease (odds ratio: 72.5 and 95% CI: 4.56, 1,153 at CT vs odds ratio: 14.6 and 95% CI: 0.96, 222 at endoscopy; P =.002). Patients were 1.89 times more likely to register pain during colonoscopy than during CT (95% CI: 1.06, 3.38; P =.03). CONCLUSION: CT colonography had no significant cardiovascular effect other than spasmolytic-induced tachycardia. Endoscopy-and colonoscopy in particular-causes cardiovascular effects that are largely related to sedation. CT colonography is less painful than colonoscopy and is comparable to flexible sigmoidoscopy. 相似文献
96.
Patients with type 2 diabetes mellitus (DM) and those with impaired glucose tolerance are at increased risk for the development of cardiovascular disease. With an increasing global incidence and prevalence of type 2 DM, and with the 2003 lowering of the glucose threshold required for the diagnosis of impaired glucose tolerance to 100 mg/dl (5.6 mmol/L), the concept of DM prevention, and presumed reduction of cardiovascular risk, is attractive. However, there is little evidence to guide the choice of DM prevention strategy and no certainty that DM prevention will result in reduced cardiovascular events or an overall favorable balance of benefit to risk. In conclusion, this review examines previous reports on DM prevention, with special attention to evidence for cardiovascular event reduction in association with specific interventions to prevent DM. 相似文献
97.
98.
KAP Meeuwis JA De Hullu MEA De Jager LFAG Massuger PCM Van De Kerkhof MM Van Rossum 《Journal of the European Academy of Dermatology and Venereology》2010,24(12):1425-1430
Background Psoriatic lesions may involve nearly all sites of the body. Involvement of the genital skin is frequently classified as part of intertriginous psoriasis without special awareness and treatment for this presentation of the disease. Gaining knowledge about the frequency of the involvement of genital skin in these patients will improve the overall care for patients with psoriasis. Objectives We studied the prevalence of genital psoriasis in the Netherlands and epidemiological characteristics of this specific presentation of the disease. Furthermore, we studied the relation between flexural and genital psoriasis. Patients/Methods A self‐administered questionnaire was sent to all 5300 members of the Dutch Psoriasis Society. Sociodemographic patient characteristics and disease‐related data (such as localization of psoriatic lesions, involvement of the genitalia, age at onset of genital psoriasis and severity of genital psoriatic lesions) were collected and analysed. Results A response rate of 37% was achieved. Almost 46% of the responding patients with psoriasis, that is 16.5% of all potential responders (n = 5300), report genital involvement at some time during the course of their disease. The genitalia can become affected at any age. Many patients with current genital involvement (38%) do not have the flexural skin affected. Conclusions A large part of patients with psoriasis suffer from genital psoriasis, which was not associated with flexural involvement in at least one third of them. More attention to the genital region is required in the current standard treatment of both male and female psoriatic patients at any age. 相似文献
99.
van Engen Catherine E Ofman Rob Dijkstra Inge ME Schackmann Martin J Wanders Ronald JA Kemp Stephan 《Tijdschrift voor kindergeneeskunde》2013,81(1):10-10
Tijdschrift voor Kindergeneeskunde - 相似文献
100.