全文获取类型
收费全文 | 2426341篇 |
免费 | 232180篇 |
国内免费 | 4202篇 |
专业分类
耳鼻咽喉 | 35387篇 |
儿科学 | 76216篇 |
妇产科学 | 63370篇 |
基础医学 | 346464篇 |
口腔科学 | 71483篇 |
临床医学 | 225033篇 |
内科学 | 485181篇 |
皮肤病学 | 53599篇 |
神经病学 | 210562篇 |
特种医学 | 97541篇 |
外国民族医学 | 886篇 |
外科学 | 370593篇 |
综合类 | 56205篇 |
现状与发展 | 1篇 |
一般理论 | 994篇 |
预防医学 | 193689篇 |
眼科学 | 56470篇 |
药学 | 181876篇 |
4篇 | |
中国医学 | 5325篇 |
肿瘤学 | 131844篇 |
出版年
2019年 | 26339篇 |
2018年 | 31797篇 |
2017年 | 27394篇 |
2016年 | 29795篇 |
2015年 | 32484篇 |
2014年 | 42573篇 |
2013年 | 60291篇 |
2012年 | 71700篇 |
2011年 | 75047篇 |
2010年 | 49255篇 |
2009年 | 45004篇 |
2008年 | 70185篇 |
2007年 | 73663篇 |
2006年 | 74584篇 |
2005年 | 72435篇 |
2004年 | 69780篇 |
2003年 | 67484篇 |
2002年 | 66768篇 |
2001年 | 113053篇 |
2000年 | 117057篇 |
1999年 | 98538篇 |
1998年 | 27871篇 |
1997年 | 25530篇 |
1996年 | 25456篇 |
1995年 | 24623篇 |
1994年 | 23171篇 |
1993年 | 21557篇 |
1992年 | 79401篇 |
1991年 | 76401篇 |
1990年 | 73577篇 |
1989年 | 70847篇 |
1988年 | 65852篇 |
1987年 | 64803篇 |
1986年 | 61342篇 |
1985年 | 58404篇 |
1984年 | 44223篇 |
1983年 | 37662篇 |
1982年 | 22890篇 |
1981年 | 20335篇 |
1979年 | 41301篇 |
1978年 | 28993篇 |
1977年 | 24350篇 |
1976年 | 22832篇 |
1975年 | 23965篇 |
1974年 | 29640篇 |
1973年 | 28050篇 |
1972年 | 26228篇 |
1971年 | 24155篇 |
1970年 | 22755篇 |
1969年 | 21089篇 |
排序方式: 共有10000条查询结果,搜索用时 131 毫秒
21.
22.
Sung‐Hyun Hwang Myung‐Chul Kim Sumin Ji Yeseul Yang Yeji Jeong Yongbaek Kim 《Cancer science》2019,110(4):1256-1267
Metformin, a drug for type 2 diabetes mellitus, has shown therapeutic effects for various cancers. However, it had no beneficial effects on the survival rate of human malignant mesothelioma (HMM) patients. The present study was performed to elucidate the underlying mechanism of metformin resistance in HMM cells. Glucose‐starved HMM cells had enhanced resistance to metformin, demonstrated by decreased apoptosis and autophagy and increased cell survival. These cells showed abnormalities in mitochondria, such as decreased ATP synthesis, morphological elongation, altered mitochondrial permeability transition pore and hyperpolarization of mitochondrial membrane potential (MMP). Intriguingly, Mdr1 was significantly upregulated in mitochondria but not in cell membrane. The upregulated mitochondrial Mdr1 was reversed by treatment with carbonyl cyanide m‐chlorophenyl hydrazone, an MMP depolarization inducer. Furthermore, apoptosis and autophagy were increased in multidrug resistance protein 1 knockout HMM cells cultured under glucose starvation with metformin treatment. The data suggest that mitochondrial Mdr1 plays a critical role in the chemoresistance to metformin in HMM cells, which could be a potential target for improving its therapeutic efficacy. 相似文献
23.
Adjuvant irradiation is the standard treatment after breast conservative surgery. Normofractionated regimen with an overall treatment time of 5 to 6 weeks is often considered as a limiting factor for irradiation compliance. In order to answer this issue, moderate and more recently extreme hypofractionated protocols appeared. We report here oncological outcomes and toxicity of hypofractionated breast irradiation. After defining the frame of moderate and extreme hypofractionated breast irradiations based on overall treatment time, patient selection criteria were listed. According to their levels of proof, the results of moderate and extreme hypofractionated breast irradiation were analysed. Overall treatment time for moderate hypofractionated breast irradiation ranged from 3 to 4 weeks, while for extreme hypofractionated breast irradiation, it was less than 1 week. For moderate hypofractionated breast irradiation, whole breast irradiation was currently performed with or without lymph node irradiation. Moderate hypofractionated breast irradiation has proven to be as safe and as efficient as normofractionated breast irradiation with level IA evidence. For extreme hypofractionated breast irradiation, phase III randomized trials confirmed that accelerated partial breast irradiation was non-inferior in terms of local control compared to normofractionated whole breast irradiation (with external beam radiation therapy and multicatheter brachytherapy), with similar acute and late toxicity. While the use of intraoperative breast irradiation remains under debate, new very accelerated partial breast irradiation (overall treatment time not exceeding 2 days) protocols emerged with encouraging results. Accelerated partial breast irradiation is warranted for extreme hypofractionated breast irradiation and is indicated for low-risk breast cancers. Moderate and extreme hypofractionated breast irradiation regimens are validated and can be routinely proposed according to patient selection criteria. 相似文献
24.
25.
Tonya J.H. White 《Journal of the American Academy of Child and Adolescent Psychiatry》2019,58(11):1042-1050
26.
Evelyne Harkemanne Jean‐Louis Dargent Pierre‐Paul Roquet‐Gravy Audrey Bulinckx 《Pediatric dermatology》2019,36(3):365-367
We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. 相似文献
27.
Jeffrey J. Silbiger 《Echocardiography (Mount Kisco, N.Y.)》2019,36(5):954-957
Secondary tricuspid regurgitation (TR) caused by right ventricular enlargement in the setting of left heart disease/pulmonary hypertension has been well described. In contrast, that associated with right atrial enlargement—atrial functional TR (AF‐TR)—remains largely underappreciated. AF‐TR most often occurs in the setting of lone atrial fibrillation, although it is also seen in its absence (idiopathic AF‐TR). Several recent studies have found that the prevalence, hemodynamic significance, and prognosis of AF‐TR are not inconsequential, suggesting increased physician awareness of this novel clinical entity is warranted. This article discusses the pathogenesis, echocardiographic findings, and treatment of this underappreciated cause of secondary TR. 相似文献
28.
29.
30.