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81.
Kiyoaki Takaba Masaki Aota Hiroyuki Koike Yutaka Konishi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(4):194-197
Aneurysm of the innominate artery is uncommon compared with other peripheral aneurysms, and holds the potential for rupture,
embolization, or thrombosis as well as various complications caused by compression to the adjacent structures. The most effective
treatment for this condition is surgical resection, but the earlier reports described high mortality rates. We report the
case of an 83-year-old asymptomatic woman with an aneurysm in the innominate artery, which was successfully resected and repaired
with the use of modern surgical techniques of hypothermic circulatory arrest and selective cerebral perfusion. Aggressive
surgical intervention should be employed despite the fact that a patients is asymptomatic. 相似文献
82.
Hiroyuki Sakai Masaki Ibe Hidetoshi Takahashi Shinobu Matsuo Kensaku Okamoto Isao Makino Yukio Oomori Hajime Iizuka 《The Journal of dermatology》1996,23(1):42-46
Langerhans cell histiocytosis is currently regarded as a reactive proliferative process of Langerhans cells rather than a malignancy. The disease is characterized by Langerhans cell infiltration of skin, lung, bone and other organs. We report a 74-year-old man with Langerhans cell histiocytosis who had generalized hemorrhagic and crusted papules. He also had diabetes insipidus. Because he did not have any severe constitutional symptoms or failure of vital organs, we applied topical PUVA treatment to his skin lesions, which responded well to the therapy. Diabetes insipidus, however, remained, in spite of X ray radiotherapy for the pituiary lesion. 相似文献
83.
Chromosomal Mapping of Genetic Locus Associated with Thymus-size Enlargement in BUF/Mna Rats 总被引:2,自引:1,他引:1
Yoshiki Murakumo Masahide Takahashi Atsushi Arakawa Mitsuhiro Saito Hiroyuki Amo Hideki Katoh Mutsushi Matsuyama 《Cancer science》1993,84(8):838-840
The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1 , which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1 , which could be allelic to Ten-1. 相似文献
84.
Yoshio Kasuga MD Akira Sugenoya Shinya Kobayashi Gengo Kaneko Hiroyuki Masuda Minoru Fujimori Shozo Takahashi Futoshi Iida 《Surgery today》1990,20(3):283-289
The purpose of this study was to evaluate the acute effects of corticosteroid and iodide preoperative therapy in patients
with Graves' disease in terms of thyroid function and immunological parameters. The above combination was prescribed for 4
patients who had experienced severe side effects from antithyroid drugs (ATD) in order to reduce the possibility of post-thyroidectomy
thyroid storm. Corticosteroids were employed daily for four days, and iodides were given daily for two weeks prior to thyroidectomy.
The free T3 values decreased rapidly to euthyroid levels following the administration of both drugs, although the free T4 values were still much higher than normal in 3 of the 4 patients at the time of surgery. By comparison, 3 of 8 patients treated
with ATD also had thyroid hormone levels above normal. Studies of lymphocyte subsets revealed that the percentage of helper
T cells was significantly less in the corticosteroidiodide treatment group than in the control and ATD groups. It is thus
possible that postoperative thyroid storm might be prevented through corticosteroid-iodide therapy by virtue of the reduction
of free T3 values to within the normal range by the time of surgery. The acute suppression of helper T cells was another result of this
form of therapy observed. 相似文献
85.
Kazunari Yamaguchi Tsukasa Inaoka Ryutaro Ohtsuka Tomoya Akimichi Tetsuro Hongo Toshio Kawabe Minato Nakazawa Makoto Futatsuka Kiyoshi Takatsuki 《Cancer science》1993,84(7):715-719
Seven hundred and twenty-three serum samples from individuals in 13 Gidra-speaking villages in Western Province, Papua New Guinea were tested for evidence of infection with human T- lymphotropic virus type I (HTLV-I), human immunodeficiency virus type I (HIV-I), hepatitis B virus (HBV) and hepatitis C virus (HCV). No samples were positive for antibodies to HIV-I. Antibodies to HTLV-I were found in 13 samples (1.8%), HBV surface antigens (HBsAg) were found in 86 samples (11.9%), and antibodies to HCV were found in 30 samples (4.1%). Six (46.2%) of 13 HTLV-I positive samples were positive for HCV or HBsAg. The seropositive rate varied in different villages and the incidence of HTLV-I and HCV was higher in coastal and riverine areas than inland. 相似文献
86.
Surgical treatment for the recurrence of colorectal cancer 总被引:2,自引:0,他引:2
Yasuhisa Yamamoto Hiroyuki Imai Sueharu Iwamoto Yutaka Kasai Tsukasa Tsunoda 《Surgery today》1996,26(3):164-168
We report the results of a retrospective study conducted on patients who developed recurrence following surgery for colorectal cancer, and present a practical plan to improve the survival rates. Of 974 patients who underwent surgery for colorectal cancer in our hospital during the 20 years between 1974 and 1993, 152 developed recurrence, as local recurrence in 70 (7.2%), as liver metastasis in 47 (4.8%), and as pulmonary metastasis in 35 (3.6%). The number of patients who underwent reoperation or curative resection was 54 (77.1%) and 13 (24.1%), respectively, of those with local recurrence, 16 (34.0%) and 6 (37.5%) of those with liver metastasis, and 6 (17.1%) and 6 (100.0%) of those with pulmonary metastasis. The 3- and 5-year survival rates were 13.4% and 8.9%, respectively, after reoperation for local recurrence, 14.4% and 0%, after reoperation for liver metastasis, and 53.3% and 53.3% after reoperation for pulmonary metastasis. Although evaluation was difficult owing to the small number of patients with lung metastasis, resection of a pulmonary lesion resulted in a good outcome. Furthermore, a significant difference in 3- and 5-year survival rates was observed between patients who underwent reoperation and those who underwent conservative treatment, for whom the survival rates were 0% and 0% following local recurrence, 4.6% and 0% following liver metastasis, and 0% and 0% following lung metastasis, at 3 and 5 years, respectively. These findings indicate that aggressive surgery for recurrence may result in a better outcome. 相似文献
87.
Hiroshi Inada Hiroyuki Horio Kiyomu Ishikawa Hiromichi Yoshikawa Eishi Harasawa Hidehiro Hosaka 《Journal of medical systems》1993,17(3-4):257-266
A filing system for ocular fundscopic image data was developed by using a personal computer for the Twin AMHTS. The development of the system was tried as one of the data transfer system including image data between two similar AMHTSs named the Twin AMHTS through the information network system. The filing system is capable of storing 26782 data of ophthalmoscopic pictures with a data compression mode by using a magneto-optical disk (MOD) whose storage capacity of both sides is 616 MB. It takes no long time for retrieval and display of the image data in the filing system. Good quality of compression and decompression obtained and reproducibility of the ocular fundus picture is favorable regardless of normal or abnormal cases. As a result, it is suggested that the developed system has practical utility although it requires more improvement. 相似文献
88.
Preconditioning of the brain with sublethal ischemia induces tolerance to subsequent lethal periods of ischemia (ischemic tolerance). In this study, we used NADPH-diaphorase histochemistry to investigate the postischemic changes of nitric oxide synthase (NOS) in the hippocampus in a rat model of cerebral ischemia and ischemic tolerance. Forebrain ischemia was induced by 4-vessel occlusion for 3 min as an ischemic preconditioning. Three days after the preconditioning or sham operation, second ischemia was induced for 6 min. A transient increase in NADPH-diaphorase activity, beginning after 2 h and maximal after 1 day, was observed in CA1 pyramidal neurons of rats subjected to 3 min of preconditioning ischemia as well as 6 min of subsequent ischemia both with and without preconditioning. In addition, expression of NADPH-diaphorase activity was seen in reactive glial cells in the damaged CA1 region of animals subjected to 6 min of ischemia without preconditioning. Thus, direct involvement of increased NADPH-diaphorase activity in ischemic tolerance was not suggested because the increased NADPH-diaphorase activity preceded the induction of ischemic tolerance which takes place 1–7 days after preconditioning. However, the present findings suggest that the induction of neuronal NADPH-diaphorase activity occurs in response to cerebral ischemia. 相似文献
89.
Kazunori Yokohata Hiroshi Kimura Gen Naritomi Hiroyuki Konomi Torahiko Takeda Yoshiaki Ogawa Masao Tanaka 《Journal of Hepato-Biliary-Pancreatic Surgery》1994,1(3):236-239
The role of endoscopic retrograde cholangiopancreatography (ERCP) in the preoperative assessment of anomalous pancreaticobiliary
junction was retrospectively evaluated in 74 consecutive patients (19 males and 55 females; aged 0–80 years). Sixty-three
patients had congenital biliary dilatation and 11 did not. Type classification of congenital biliary dilatation was possible
by ERCP alone in 45 patients (71%). The main causes of classification failure were previous bilio-enteric anastomosis and
restriction of postural changes during ERCP due to general anesthesia in pediatric patients. Classification of anomalous junction
was possible in 69 patients (93%). Technical difficulty in ERCP caused classification failure in 5 patients. Neoplastic lesions
were found in 12 patients (16%) and all but 1 were correctly diagnosed by ERCP. We conclude that ERCP plays an important role
in the preoperative diagnosis and type classification of anomalous pancreaticobiliary junction and congenital biliary dilatation. 相似文献
90.
Hiroyuki Motoie Atsushi Okazaki Hiroyuki Kanoh Hisataka Shikama Takashi Fujikura 《Basic & clinical pharmacology & toxicology》1997,81(1):42-47
Abstract: We have evaluated the relationship between bone mass and mechanical properties of bone from male and female rats treated with YM175, a novel bisphosphonate, for 104 weeks. YM175 [disodium (cycloheptylamino) methylenediphosphonate monohydrate] was given via the drinking water at a concentration of 0, 0.005, 0.015, 0.05, or 0.15%. Since the mortality in the male 0.15% group exceeded the exclusion criteria (75%) at week 88, this group was omitted from the study. Mean daily intake of YM175 was 2.2-22.1 mg/kg for males and 3.6-104 mg/kg for females. After the treatment, mechanical properties and ash weight of the humerus were determined. In males, 0.015 and 0.05% of YM175 (6.6–22.1 mg/kg) significantly increased failure load of the midshaft. In females, failure load and stiffness of the midshaft tended to be increased by YM175 (up to 104 mg/kg). Furthermore, ultimate compressive load at the humeral metaphysis treated with the highest dose of YM175 was 2- or 3.5-fold greater than that of untreated male or female control. Ash weight of the humerus was increased dose-dependently and was positively correlated with failure load of the midshaft. These findings indicate that treatment for 2 years with YM175 increased bone mass and mechanical strength without blocking bone mineralization. 相似文献