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31.
Interleukin-11 expression: its significance in eutopic and ectopic human implantation 总被引:5,自引:0,他引:5
von Rango U Alfer J Kertschanska S Kemp B Müller-Newen G Heinrich PC Beier HM Classen-Linke I 《Molecular human reproduction》2004,10(11):783-792
Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a functional placenta are crucial for establishment and maintenance of pregnancy. Interleukin-11 signalling has been shown to be obligatory for adequate decidualization and trophoblast invasion in mice. Defects in IL-11 signalling in mice result in trophoblast over-invasion and fetal loss. The pathological situation of human tubal pregnancy resembles that of IL-11Ralpha(-/-) mice concerning these symptoms. As our interest is focused on the human early pregnancy, we compared IL-11 expression at the implantation site of ectopic tubal pregnancy (EP) to 1st and 2nd trimester of normal intrauterine pregnancies (IP), and to the normal cycling endometrium. The mRNA expression of IL-11 and IL-11Ralpha was analysed by semiquantitative RT-PCR. Protein expression was detected by western blotting and immunohistochemistry. IL-11Ralpha is expressed constitutively in all tissue specimens analysed. IL-11 is expressed predominantly during follicular and early luteal phase of the menstrual cycle. In IP, IL-11 expression peaks during the 1st trimester and declines from the beginning of the 2nd trimester onwards. In tubal abortions, IL-11 expression is reduced in comparison to vital EP and IP. Cultured primary endometrial and decidual epithelial cells were analysed for hormonal regulation of IL-11 by enzyme-linked immunosorbent assay and RT-PCR. IL-11 is up-regulated by estrogen and down-regulated by progesterone. Overall, our results indicate that in humans, IL-11 signalling is significantly involved in regulation of trophoblast invasion. In the case of tubal abortion, inadequate IL-11 signalling may therefore result in dysregulation of trophoblast invasion. 相似文献
32.
Gehring U Brunekreef B Fahlbusch B Wichmann HE Heinrich J;INGA Study Group 《Allergy》2005,60(8):1079-1082
BACKGROUND: Moisture is vitally important for house dust mites and they cannot survive in cold or hot-dry climates. AIMS OF THE STUDY: To investigate the influence of two extraordinarily cold and dry winters in 1995/1996 and 1996/1997 on house dust mite levels in German homes. METHODS: Dust samples were collected between June 1995 and December 2001 on the mattresses of 655 adults and 454 schoolchildren living in five different areas of Germany. We compared house dust mite allergen Dermatophagoides pteronyssinus (Der p 1) levels before and during the winters of 1995/1996 and 1996/1997 with levels after these winters. RESULTS: D. pteronyssinus (Der p 1) levels in samples taken after the cold winters of 1995/1996 and 1996/1997 were approximately two times lower than Der p 1 levels in dust samples collected before or during these respective winters (Geometric means: Erfurt 89 vs 33 ng/g; Hamburg 333 vs 219 ng/g; Bitterfeld, Hettstedt, and Zerbst 296 vs 180 ng/g). Except for Hamburg, the decrease in Der p 1 levels was statistically significant. D. pteronyssinus levels measured in dust samples collected in 2001 (i.e. 3 years after the two cold winters) show a statistically non-significant increase (Geometric means: Erfurt 33 vs 39 ng/g; Hamburg 219 vs 317 ng/g), suggesting that it may take a long time for mite allergen levels to increase again after a sudden decrease. CONCLUSION: We conclude that Der p 1 levels in German mattress dust samples have been approximately reduced by a factor of three to four by the two consecutive cold winters of 1995/1996 and 1996/1997. 相似文献
33.
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors 总被引:1,自引:0,他引:1
34.
Repeated measurements of body composition and subcutaneous fat distribution were obtained in female gymnasts to test the hypothesis of a selective response from localized fat deposits to intense physical training. Repeated measurements were obtained on the members of three nationally ranked collegiate gymnastic teams: at the beginning and peak of the training season. The highest ranked team was measured a third time, three weeks after the end of the competitive season. Body composition was estimated using anthropometry and bioelectric impedance; subcutaneous fat thickness was measured using skinfold calipers and ultrasound images of adipose tissue thickness (ATT). The mean difference between baseline and peak measurements were statistically significant (P ? .05) for the triceps and suprailiac skinfolds, and for the adipose tissue thickness at the suprailiac and hypogastric sites. There were no significant changes in weight, percentage of body fat, circumferences, or subcutaneous fat thickness at the subscapular, calf or medial thigh sites. In the team with three sets of measurements, only the triceps skinfold and the suprailiac ATT showed a statistically significant effect of training. © 1993 Wiley-Liss, Inc. 相似文献
35.
Chiral combined liquid-crystalline polymers (i. e. polymers with the mesogenic groups in the main chain as well as in the side groups) with dipole moments perpendicular to the mesogenic groups were synthesized and characterized. These dipole moments were introduced by lateral substituents, which were located at different parts of the mesogen or directly at the chiral centre. The polymers, thus prepared, show crystalline or glassy phases at room temperature and smectic A, chiral smectic C* or cholesteric phases at higher temperatures. Since the lateral substituents decrease the melting temperature more strongly than the clearing temperature, the liquid-crystalline phases are broadened compared to the unsubstituted polymers. Often glassy liquid-crystalline phases are obtained. The dipole moments perpendicular to the mesogenic groups or at the chiral centre may help to obtain a high spontaneous polarisation in the chiral smectic C* phase (ferroelectricity). 相似文献
36.
Fabian Heinrich Kira Meißner Felicia Langenwalder Klaus Püschel Dominik Nrz Armin Hoffmann Marc Lütgehetmann Martin Aepfelbacher Eric Bibiza-Freiwald Susanne Pfefferle Axel Heinemann 《Emerging infectious diseases》2021,27(1):329
Analyses of infection chains have demonstrated that severe acute respiratory syndrome coronavirus 2 is highly transmissive. However, data on postmortem stability and infectivity are lacking. Our finding of nasopharyngeal viral RNA stability in 79 corpses showed no time-dependent decrease. Maintained infectivity is supported by virus isolation up to 35 hours postmortem. 相似文献
37.
38.
Recently we reported that perfusion of hippocampal slices with epidermal growth factor (EGF) lead to enhancement of potentiated responses after tetanic stimulation. In the present study we report that basic fibroblast growth factor (FGF) can also lead to an enhancement of potentiated responses. FGF is a mitogen for several cell types and exhibits neurotrophic effects on neurons of the central nervous system (CNS). Rat hippocampal slices were perfused with FGF at a concentration of 10-9 M. During extra- and intracellular recordings in the CA1-region, the addition of FGF to the perfusing medium produced no change in evoked responses if single pulse or paired pulse stimulation was used. Furthermore FGF had no influence on the resting membrane potential and input resistance. However, after tetanic stimulation, FGF-treated slices showed an increase in the magnitude of potentiation compared to control slices. Taken together with the EGF data these results support the hypothesis that growth factors like FGF with neurotrophic potential on CNS-neurons can influence synaptic efficacy. Furthermore these results show that factors which are able to modulate developmental plasticity and regenerative plasticity can also modulate synaptic plasticity. 相似文献
39.
Endoscopic cordectomy. a proposal for a classification by the Working Committee, European Laryngological Society 总被引:6,自引:0,他引:6
M. Remacle Hans E. Eckel Antonio Antonelli Daniel Brasnu Dominique Chevalier Gerhard Friedrich Jan Olofsson Heinrich H. Rudert Walter Thumfart Marco de Vincentiis Thomas P. U. Wustrow 《European archives of oto-rhino-laryngology》2000,257(4):227-231
The European Laryngological Society is proposing a classification of different laryngeal endoscopic cordectomies in order
to ensure better definitions of postoperative results. We chose to keep the word “cordectomy” even for partial resections
because it is the term most often used in the surgical literature. The classification comprises eight types of cordectomies:
a subepithelial cordectomy (type I), which is resection of the epithelium; a subligamental cordectomy (type II), which is
a resection of the epithelium, Reinke’s space and vocal ligament; transmuscular cordectomy (type III), which proceeds through
the vocalis muscle; total cordectomy (type IV); extended cordectomy, which encompasses the contralateral vocal fold and the
anterior commissure (type Va); extended cordectomy, which includes the arytenoid (type Vb); extended cordectomy, which encompasses
the subglottis (type Vc); and extended cordectomy, which includes the ventricle (type Vd). Indications for performing those
cordectomies may vary from surgeon to surgeon. The operations are classified according to the surgical approach used and the
degree of resection in order to facilitate use of the classification in daily practice. Each surgical procedure ensures that
a specimen is available for histopathological examination.
Received: 29 December 1998 / Accepted: 2 July 1999 相似文献
40.
Tumors of the scapula are an unusual clinical challenge. Partial or complete resection of the scapula, with its attached musculoaponeurotic tissue, is a seldom used technique for the treatment of primary bone and soft tissue tumors, as well as selected metastatic involvement of the scapula. Scapulectomy may allow wide margins of resection without amputation. The purpose of this study is to review our recent experience with scapulectomy. This study describes the recent experience with scapulectomy by the Section of Surgical Oncology and the Department of Orthopedics at Louisiana State Medical Center (New Orleans, LA). Between 1994 and 1998, 12 patients (between 16 and 79 years of age) underwent a resection of the scapula. Eleven of these patients had soft tissue tumors; one had a metastasis from a thyroid carcinoma. Six of these patients underwent a scapulectomy as a primary treatment, five for recurrence. Six patients also received postoperative radiation and/or chemotherapy. The follow-up ranged from 6 months to 4 years. There was no mortality or wound infection associated with scapulectomy. All patients had normal hand and wrist function after surgery. Three distant recurrences occurred, with no local or regional failures encountered during the follow-up period. Scapulectomy can result in excellent local tumor control. Whereas some loss of active shoulder motion may occur, hand, wrist and elbow function is preserved. Although maintenance of shoulder function should not take precedence over adequacy of resection, scapulectomy remains an excellent procedure for malignant disease that preserves hand, wrist, and elbow function. 相似文献