全文获取类型
收费全文 | 955篇 |
免费 | 117篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 71篇 |
妇产科学 | 11篇 |
基础医学 | 149篇 |
口腔科学 | 7篇 |
临床医学 | 112篇 |
内科学 | 174篇 |
皮肤病学 | 17篇 |
神经病学 | 76篇 |
特种医学 | 178篇 |
外科学 | 77篇 |
综合类 | 20篇 |
预防医学 | 69篇 |
眼科学 | 4篇 |
药学 | 62篇 |
肿瘤学 | 51篇 |
出版年
2022年 | 7篇 |
2021年 | 9篇 |
2020年 | 14篇 |
2019年 | 10篇 |
2018年 | 14篇 |
2017年 | 10篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 38篇 |
2012年 | 20篇 |
2011年 | 39篇 |
2010年 | 21篇 |
2009年 | 24篇 |
2008年 | 28篇 |
2007年 | 43篇 |
2006年 | 36篇 |
2005年 | 38篇 |
2004年 | 20篇 |
2003年 | 29篇 |
2002年 | 38篇 |
2001年 | 25篇 |
2000年 | 31篇 |
1999年 | 25篇 |
1998年 | 26篇 |
1997年 | 29篇 |
1996年 | 26篇 |
1995年 | 18篇 |
1994年 | 23篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 27篇 |
1989年 | 31篇 |
1988年 | 29篇 |
1987年 | 15篇 |
1986年 | 31篇 |
1985年 | 20篇 |
1984年 | 22篇 |
1983年 | 11篇 |
1982年 | 17篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 17篇 |
1978年 | 12篇 |
1977年 | 12篇 |
1976年 | 12篇 |
1975年 | 15篇 |
1974年 | 8篇 |
1971年 | 11篇 |
排序方式: 共有1079条查询结果,搜索用时 15 毫秒
41.
42.
Holdsworth M Gerber M Haslam C Scali J Beardsworth A Avallone MH Sherratt E 《European journal of clinical nutrition》2000,54(7):530-539
BJECTIVEe: The investigation involves comparison of dietary behaviour between UK and Mediterranean France by characterizing the pattern of the current French Mediterranean diet compared with the current British diet. DESIGN: The findings of two dietary surveys, one in the UK and one in France, are compared. An interviewer-administered questionnaire was used in both countries. Questions on food frequency were used to assess dietary behaviour, which were regrouped in the French survey to correspond with UK groupings. Dietary indices were constructed to describe dietary behaviour in relation to cancer recommendations for intake of fat, fibre, meat, fruit and vegetables. SETTING: The UK study was conducted in Leicestershire, central England and the French study was carried out in Hérault, southern France. Subjects: UK: n=418 subjects (57.9% female and 42.1% male; mean age=45.0 y); France: n=635 subjects (50.1% female and 40.9% male; mean age=49.8 y). Age range of both samples: 20-74 y. RESULTS: There were positive and negative trends in food consumption in each country. UK respondents reported eating more beans and pulses (P=0.000), less cheese (P=0. 000), red meat (P=0.001), and processed meats (P=0.000) than French respondents. However, on the negative side, they ate less fruit and vegetables (P=0.000), fish and poultry (P=0.000), cereals (P=0.000), and more sweets and chocolates (P=0.000), and cakes, pastries, biscuits and puddings (P=0.000). Women had healthier diets in both countries. CONCLUSIONS: Overall the southern French diet was healthier as French respondents scored significantly better for indices for fat, dietary fibre, fruit and vegetables (P=0.000 in all cases). However, the French sample scored poorer for the meat index (P=0.000). SPONSORSHIP: This study was supported by a grant from l'Association de la Recherche contre le Cancer (ARC) awarded to M Holdsworth. 相似文献
43.
A diagnostic survey was undertaken of children aged 11 to 19 years in Tameside with severe learning difficulties (intelligence quotient less than or equal to 50). Eighty-two children were identified and their medical records reviewed. A specific diagnosis for the retardation was documented in 25 (30%) of the children, 18 of whom had Down''s syndrome. A probable aetiology or a disorder of unknown aetiology had been identified in a further 21 (26%) children. To confirm the existing diagnosis, identify new diagnoses, and offer genetic counselling, the parents of 63 children were offered detailed reassessment of their child. Fifty three children were reviewed, and a specific disorder identified in 25 out of 31 previously undiagnosed children. The most frequent diagnoses made were fragile X syndrome and Rett''s syndrome. On completion of the survey, 61 of the 82 children (74%) had a specific diagnosis or probable aetiology identified, 12 (15%) had associated disorders such as cerebral palsy, and in only nine of the 82 children (11%) were there no clues at all to the cause of their retardation. 相似文献
44.
Margaret E. Furness FRACR Samuel Rajadurai MD Ross R. Haslam FRACP Roger C. Weckert DMU John A. O''Loughlin FRACOG 《The Australian & New Zealand journal of obstetrics & gynaecology》1988,28(3):193-196
Two cases of fetal renal vein thrombosis, diagnosed via maternal ultrasound scan are presented. One was associated with severe placental dysfunction and demonstrated haematuria and renal failure which resolved on day 10. The other followed an antepartum haemorrhage and resolved before the baby was born. The ultrasound showed, as transient findings, unilateral renal enlargement, thrombus protruding into the inferior vena cava, and mild fetal ascites. We suggest that fetal renal vein thrombosis may be more common than previously suspected, and warrants close monitoring of fetal well-being. Delivery should be considered if there is other evidence of fetal compromise, if the amount of peritoneal fluid suggests substantial haemorrhage, or if there is propagating thrombus in the inferior vena cava. 相似文献
45.
Haslam N 《The Australian and New Zealand journal of psychiatry》2003,37(6):696-704
OBJECTIVE: To review studies of the categorical versus dimensional status of mental disorders that employ taxometric methodology. METHOD: A comprehensive qualitative review of all published taxometric studies of psychopathology. RESULTS: Categorical and dimensional models each receive well-replicated support for some groups of mental disorders. Studies favour categorical models for melancholia, eating disorders, pathological dissociation, and schizotypal and antisocial personality disorders. Dimensional models tend to be favoured for the broad neurotic spectrum--general depression, generalized anxiety, posttraumatic stress disorder--and for borderline personality disorder. CONCLUSIONS: Taxometric research clarifies the latent structure of psychopathology in ways that have implications for the classification, assessment, explanation and conceptualization of mental disorder. 相似文献
46.
47.
48.
AIM: The purpose of this study was to evaluate the usefulness of gadolinium enhanced 3D magnetic resonance (MR) angiography (CE MRA) as an alternative to translumbar or brachial angiography in the pre-operative work-up of patients with aortoiliac occlusion. MATERIALS AND METHODS: Nineteen patients (14 men and five women; age range 45-77 years; mean 62 years), not suitable for perfemoral angiography (aortoiliac occlusion, n = 18; infected femoro-femoral graft with femoral artery pseudoaneurysm, n = 1), underwent pre-operative CE MRA and catheter angiography (translumbar, n = 5; brachial, n = 14). CE MRA was performed using a 3D fast spoiled gradient-recalled pulse sequence during the intravenous injection of 40 ml of gadolinium DTPA and a 32-s breath-hold. All patients subsequently underwent surgical (n = 13) or percutaneous transluminal (n = 6) treatment for their vascular disease. The accuracy of CE MRA was determined compared with the findings at catheter angiography taken as the gold standard. RESULTS: CE MRA gave accurate information about the occlusion, inflow and distal run-off in the majority of patients. CE MRA revealed occlusions with an accuracy of 94.7% in the aortic segment, 98.7% in the iliac segment, and 100% in the common femoral segment. The arterial segments distal to the common femoral artery were not completely visualized in four patients but CE MRA provided sufficient information to plan either surgical or percutaneous transluminal therapy in all but one patient. CONCLUSION: CE MRA is highly accurate in showing the presence and extent of aortoiliac occlusions. In our study group, CE MRA gave sufficient information in the pre-operative evaluation of aortoiliac occlusion. 相似文献
49.
Xie Y Skytting B Nilsson G Gasbarri A Haslam K Bartolazzi A Brodin B Mandahl N Larsson O 《Cancer research》2002,62(13):3861-3867
The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growth. This effect is specific for SYT-SSX, without involving the wild-type genes SYT or SSX. The decrease in cyclin D1 expression, which occurred shortly after inhibition of SYT-SSX expression, was found to be primarily dependent on an increased degradation of the cyclin D1 protein, as assessed by pulse-chase experiments using [(35)S]methionine. Furthermore, transfection of mouse fibroblasts with SYT-SSX cDNA increased the stability of cyclin D1. Because treatment with a proteasome inhibitor restored cyclin D1 expression, it seems like SYT-SSX interferes with ubiquitin-dependent degradation of cyclin D1. However, SYT-SSX-regulated cyclin D1 expression was proven to be independent of the glycogen synthetase kinase-3beta pathway. Taken together, our study provides evidence that SYT-SSX stabilizes cyclin D1 and is critical for cyclin D1 expression in synovial sarcoma cells. SYT-SSX-dependent expression of cyclin D1 may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy. 相似文献
50.
Percutaneous Gastrostomy in Patients Who Fail or Are Unsuitable for Endoscopic Gastrostomy 总被引:3,自引:1,他引:2
Thornton FJ Varghese JC Haslam PJ McGrath FP Keeling F Lee MJ 《Cardiovascular and interventional radiology》2000,23(4):279-284
Purpose: Percutaneous endoscopic gastrostomy (PEG) is not possible or fails in some patients. We aimed to categorize the reasons for
PEG failure, to study the success of percutaneous radiologic gastrostomy (PRG) in these patients, and to highlight the associated
technical difficulties and complications.
Methods: Forty-two patients (28 men, 14 women; mean age 60 years, range 18–93 years) in whom PEG failed or was not possible, underwent
PRG. PEG failure or unsuitability was due to upper gastrointestinal tract obstruction or other pathology precluding PEG in
15 of the 42 patients, suboptimal transillumination in 22 of 42 patients, and advanced cardiorespiratory decompensation precluding
endoscopy in five of 42 patients. T-fastener gastropexy was used in all patients and 14–18 Fr catheters were inserted.
Results: PRG was successful in 41 of 42 patients (98%). CT guidance was required in four patients with altered upper gastrointestinal
anatomy. PRG failed in one patient despite CT guidance. In the 16 patients with high subcostal stomachs who failed PEG because
of inadequate transillumination, intercostal tube placement was required in three and cephalad angulation under the costal
margin in six patients. Major complications included inadvertent placement of the tube in the peritoneal cavity. There was
one case of hemorrhage at the gastrostomy site requiring transfusion and one case of superficial gastrostomy site infection
requiring tube removal. Minor complications included superficial wound infection in six patients, successfully treated with
routine wound toilette.
Conclusion: We conclude that PRG is a safe, well-tolerated and successful method of gastrostomy and gastrojejunostomy insertion in the
technically difficult group of patients who have undergone an unsuccessful PEG. In many such cases optimal clinical evaluation
will suggest primary referral for PRG as the preferred option. 相似文献