The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model

BackgroundExcessive portal pressure after massive hepatectomy can cause hepatic sinusoidal injury and have deleterious impacts on hepatic functional recovery, contributing to developing post-hepatectomy liver failure. This study aimed to assess the effects of splanchnic vasoactive agents on hepatic functional recovery and regeneration while clarifying the underlying mechanism, using a 70% hepatectomy porcine model.MethodsEighteen pigs undergoing 70% hepatectomy were involved in this study and divided into three groups: control (n=6), terlipressin (n=6), and octreotide (n=6). Terlipressin (0.5 mg) and octreotide (0.2 mg) were administered 3 times a day for each group with the first dose starting just before surgery until the 7th postoperative day, at which time the surviving pigs were sacrificed. During the period, portal pressure, liver weight, biochemical analysis, histological injury score, and molecular markers were evaluated and compared between groups.ResultsThe 7-day survival rates in the octreotide, terlipressin, and control groups were 100%, 83.3%, and 66.7%, respectively. The portal pressures decreased in both terlipressin and octreotide groups than the control group at 30 minutes, 1 hour and 6 hours after hepatectomy. The amount of regeneration measured by liver weight to body weight ratio at the time of sacrifice in the terlipressin group was smaller than that in the control group (117% vs. 129%, P=0.03). Serum aspartate aminotransferase (AST) and total bilirubin levels at 1 and 6 hours after hepatectomy and prothrombin time/international normalized ratio (PT/INR) at 6 hours after hepatectomy were significantly improved in the terlipressin and octreotide groups compared to the control group. Serum endothelin-1 (ET-1) was significantly lower in the terlipressin group than that in the control group 6 hours after hepatectomy (P<0.01). The histological injury score in the control group was significantly higher than that in the terlipressin group on the 7th postoperative day (P<0.01).ConclusionsSplanchnic vasoactive agents, such as terlipressin and octreotide, could effectively decrease portal pressure and attenuate liver injury after massive hepatectomy.     

The introduction of treatment and the cultural adaptability of western psychotherapies for eating disorders in China

In the past 40 years, the prevalence of eating disorders (ED) in China has shown an increasing trend, leading to an urgent need to develop efficient treatment modes and methods. Since the beginning of the new century, the diagnosis, treatment, and research of ED in China have been under development. This article gives an introduction and commentary on the treatment modes, treatment methods and their applications in ED in China. There are two main treatment forms for ED until now, that is, inpatient treatment and outpatient treatment. Inpatient treatment is recommended as the first choice. Since 2008, clinical psychotherapies such as cognitive behavioral therapy (CBT), dialectical behavioral therapy (DBT), and family-based treatment (FBT), which are effective for pathological symptoms of ED, have been introduced into China and developed clinically. Group CBT and group DBT for patients with ED and group FBT for caregivers might be the most efficient psychotherapy in China nowadays. A multi-family FBT support group could be developed as the basic treatment of ED patients. Although these new types of psychotherapy have observed effectiveness in clinical application, the Randomized Controlled Trials (RCT) are rare and need to be developed.     

Surface modification of titanium implant by microarc oxidation and hydrothermal treatment

Surface modification of titanium implant is processed by microarc oxidation and hydrothermal treatment. A porous surface with a biologically active bone-like apatite layer was formed. The apatite layer consists of very fine crystals and high crystallinity and is integrated with the titanium alloy substrate with a graded structure without a distinct interface. Such a bioactive layer is expected not only to enhance the bony ingrowth into the porous structure, but also to improve the interlocking between implant and bone.     

尿毒症患者急性缺氧状态下血清红细胞生成素浓度的变化

７例尿毒症贫血患者在自发急性缺氧状态下，其血清红细胞生成素（ＥＰＯ）浓度显著提高（平均７倍），且与ＰＯ２呈负相关。缺氧状态纠正后血清ＥＰＯ浓度下降。提示尿毒症贫血患者的ＥＰＯ氧依赖调控系统功能尚存在，但处于不敏感的低调状态。进一步了解其机遇，则可能通过促进内源性ＥＰＯ的生成，有助于悄毒症贫血的治疗。     

Design and Simulation of Active Biochip System

To solve the problems existing in passive biochip systems, we designed a novel active biochip system. This system introduces negative pressure and controlling devices to adjust the antigen-antibody reaction on the nitrocellulose membrane. Computational simulation demonstrated that this system is a rapid, stable, robust and practical system that may enhance the efficiency of antigen-antibody reactions and improve the repeatability and accuracy of biochip analysis.     

会厌在喉部分切除喉功能重建术中的应用

目的 探讨会厌在喉部分切除喉功能重建术中的应用价值。方法 １９９２年１２月－１９９６年１月３２例不同分期的声门型,声门上型喉癌行喉部分切除术,将残存会厌下移保留喉功能。结果 ２１例声门型喉癌术后１９例拔除气管套管恢复喉的全部功能,１１例声门上型喉癌５例恢复喉全部功能,并于术后１４－１８ｄ恢复吞咽功能,无１例出现误吸收起严重并发症。３年生存率８７．５％（２８／３２）,５年生存率５８．３％（７／１２）     

间歇性外斜视手术治疗的临床观察

目的:对56例间歇性外斜视术后患者进行追踪观察,探讨手术年龄与双眼视觉恢复率的关系.方法:手术前后用三棱镜遮盖法,同视机检查斜视度,AC/A比值及视网膜对应情况,术后进行同视机训练.结果:4～7岁双眼视觉恢复率最高,与8～13岁组之间差异有高度显著性(P<0.01),8～13岁组与14～17岁组差异有显著性(P<0.05),14～17岁组与18岁以上组之间差异无显著性(P>0.05).结论:对间歇性外斜视患者应早期手术,年龄越小术后双眼视觉恢复率越高.同视机训练使一些患者能重新建立起正常视网膜对应,恢复双眼单视功能.     

鼻咽癌组织中微血管的分布

目的：观察鼻咽癌组织中微血管的分布及存在状况,探讨其与鼻咽癌的临床病理联系。方法：采用免疫组织化学Ｓ－Ｐ法,检测血栓调节蛋白在鼻咽癌血管内皮细胞的表达,进行微血管的定性半定量研究。结果：鼻咽癌组织中微血管的分布不均匀。极性消失。血管呈分支芽状弥漫分布于癌组织中,或呈条索状围绕癌细胞团。微血管的数目与癌细胞的增殖指数屯预后正相关。结论：鼻咽癌组织中微血管数与患者的生存期有关。     

严重烧伤病人早期肾功能损害与早期糖尿症的相关性研究

目的 :通过对严重烧伤病人进行应激性糖尿症和早期肾功能损害等并发症观察研究 ,进一步了解其发病机制。方法 :对重度烧伤病人进行血 BS、BUN、Cr、UA、TNFα、INS、β2 - MG及尿糖、尿 PRO、尿 p H、尿β2 - MG等进行监测。结果 :发现 5例病人在血糖不高的情况下出现糖尿和不同程度的肾功能损害。结论 :部分严重烧伤病人早期糖尿是由肾脏近曲小管吸收障碍引起。