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排序方式: 共有212条查询结果,搜索用时 46 毫秒
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Michal Boyd RN NP ND Delwyn Armstrong MPH Janet Parker RN MN NP Carole Pilcher RN MN Lifeng Zhou PhD Barbara McKenzie‐Green RN PhD Martin J. Connolly MD 《Journal of the American Geriatrics Society》2014,62(10):1962-1967
Residents of long‐term care facilities have highly complex care needs and quality of care is of international concern. Maintaining resident wellness through proactive assessment and early intervention is key to decreasing the need for acute hospitalization. The Residential Aged Care Integration Program (RACIP) is a quality improvement intervention to support residential aged care staff and includes on‐site support, education, clinical coaching, and care coordination provided by gerontology nurse specialists (GNSs) employed by a large district health board. The effect of the outreach program was evaluated through a randomized comparison of hospitalization 1 year before and after program implementation. The sample included 29 intervention facilities (1,425 residents) and 25 comparison facilities (1,128 residents) receiving usual care. Acute hospitalization rate unexpectedly increased for both groups after program implementation, although the rate of increase was significantly less for the intervention facilities. The hospitalization rate after the intervention increased 59% for the comparison group and 16% for the intervention group (rate ratio (RR) = 0.73, 95% confidence interval (CI) = 0.61–0.86, P < .001). Subgroup analysis showed a significantly lower rate change for those admitted for medical reasons for the intervention group (13% increase) than the comparison group (69% increase) (RR = 0.67, 95% CI = 0.56–0.82, P < .001). Conversely, there was no significant difference in the RR for surgical admissions between the intervention and comparison groups (RR = 1.0, 95% CI = 0.68–1.46, P = .99). The integration of GNS expertise through the RACIP intervention may be one approach to support staff to provide optimal care and potentially improve resident health. 相似文献
174.
Murine monoclonal antibody MB-2D10 recognizes Rh-related glycoproteins in the human red cell membrane 总被引:1,自引:0,他引:1
G Mallinson ; DJ Anstee ; ND Avent ; K Ridgwell ; MJ Tanner ; GL Daniels ; P Tippett ; AE von dem Borne 《Transfusion》1990,30(3):222-225
The human red cell membrane components reacting with monoclonal antibody MB-2D10 were examined by immunoblotting. The antibody bound to a diffusely staining band extending from Mr 30,000 up to the high-molecular-weight region of the gel in normal membranes and in Rhnull U + membranes, but not in Rhnull U - membranes. Treatment of normal red cells with an endoglycosidase F-containing preparation destroyed the epitope recognized by MB-2D10. The reactivity of the antibody with purified preparations of Rh-related glycoproteins D30 polypeptide, D50 polypeptide, R6A32 polypeptide, and R6A45 polypeptide was also examined. Only the purified R6A45 and D50 components reacted with MB-2D10. These results show that MB-2D10 recognizes a carbohydrate-dependent epitope on the R6A45 and D50 group of Rh-related polypeptides. The results also suggest the possibility that the U antigen arises from interaction between glycophorin B and the Rh-related components D50 and R6A45. 相似文献
175.
Jay K. Udani MD Donald J. Brown ND Maria Olivia C. Tan MS Mary Hardy MD 《Journal of the American College of Nutrition》2013,32(6):428-435
Objective: 7-Hydroxymaitairesinol (7-HMR) is a naturally occurring plant lignan found in whole grains and the Norway spruce (Piciea abies). The purpose of this study was to evaluate the bioavailability of a proprietary 7-HMR product (HMRlignan, Linnea SA, Locarno, Switzerland) through measurement of lignan metabolites and metabolic precursors. Methods: A single-blind, parallel, pharmacokinetic and dose-comparison study was conducted on 22 postmenopausal females not receiving hormone replacement therapy. Subjects were enrolled in either a 36 mg/d (low-dose) or 72 mg/d dose (high-dose) regimen for 8 weeks. Primary measured outcomes included plasma levels of 7-HMR and enterolactone (ENL), and single-dose pharmacokinetic analysis was performed on a subset of subjects in the low-dose group. Safety data and adverse event reports were collected as well as data on hot flash frequency and severity. Results: Pharmacokinetic studies demonstrated 7-HMR C max = 757.08 ng/ml at 1 hour and ENL C max = 4.8 ng/ml at 24 hours. From baseline to week 8, plasma 7-HMR levels increased by 191% in the low-dose group (p < 0.01) and by 1238% in the high-dose group (p < 0.05). Plasma ENL levels consistently increased as much as 157% from baseline in the low-dose group and 137% in the high-dose group. Additionally, the mean number of weekly hot flashes decreased by 50%, from 28.0/week to 14.3/week (p < 0.05) in the high-dose group. No significant safety issues were identified in this study. Conclusion: The results demonstrate that HMRlignan is quickly absorbed into the plasma and is metabolized to ENL in healthy postmenopausal women. Clinically, the data demonstrate a statistically significant improvement in hot flash frequency. Doses up to 72 mg/d HMRlignan for 8 weeks were safe and well tolerated in this population. 相似文献
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Diana Cardenas MD PhD Gustavo Díaz RD MSc Vanessa Fuchs-Tarlovsky MD PhD Maria Cristina Gonzalez MD PhD Fernando Carrasco MD PhD Angélica María Pérez Cano RD MSc Charles Bermúdez MD Claudia Maza ND Eduardo Ferraresi MD Fernando Lipovestky MD Haydee Villafana ND Humberto Arenas-Márquez MD Isabel Calvo MD Ludwig Roberto Alvarez Cordova MD Marisa Canicoba RD Paola Sánchez RD MD Sergio Santana MD Serrana Tihista RD Gertrudis M. Adrianza de Baptista RDN MS Yawelida Garcia RN Maria Isabel Toulson Davisson Correia MD PhD 《JPEN. Journal of parenteral and enteral nutrition》2022,46(3):635-645
179.
Wendy M. Gordon CPM LM MPH Safiya A. U. McCarter ND MSAOM Susan J. Myers CPM LM MPH 《Journal of Midwifery & Women's Health》2016,61(6):721-725
Creating a socially conscious educational environment is an imperative if health care practitioners are to have a significant impact on health inequities. The effects of practitioner bias, prejudice, and discrimination on health and health outcomes have been well documented in the literature. Individuals being trained to provide health care will be entering into an increasingly diverse world and must be equipped with the appropriate knowledge and skills in order to meet the needs of those seeking their care. Cultural competency training in medical education has evolved over the past 15 years since the Institute of Medicine's 2002 report, Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. As research on the effectiveness of this training has emerged, several authors have called for the integration of antiracism training into the cultural competency curriculum, but few have found effective ways of doing so. This article describes the approach of one midwifery program in order to inform clinical education programs across the spectrum of health care practitioners. 相似文献
180.
Shannon M. Conroy PhD MPH Julie Von Behren MPH Marilyn L. Kwan PhD Lawrence H. Kushi ScD Mi-Ok Kim PhD Carlos Iribarren MD PhD MPH Janise M. Roh MSW MPH Cecile A. Laurent MS Catherine Thomsen MPH Janet N. Chu MD MPH MAS Heather Greenlee ND PhD MPH Scarlett Lin Gomez PhD MPH Salma Shariff-Marco PhD MPH 《Cancer》2023,129(15):2395-2408