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101.
KOYO NISHIDA NORIHITO SATO HITOSHI SASAKI JUNZO NAKAMURA 《The Journal of pharmacy and pharmacology》1995,47(3):227-231
We examined the effect of dose and transport inhibitors on the pharmacokinetics of phenol red as a model drug after application to rat liver surface in-vivo, employing a cylindrical glass cell (i.d. 9 mm, area 0·64 cm2), to elucidate the mechanism for drug absorption from liver surface membrane. Absorption ratios of phenol red in 6 h were determined to be 91·1, 91·8 and 89·9% at a dose of 0·3, 1 and 3 mg, respectively. The AUC value for plasma concentration profile of phenol red was proportional to the dose. It is thus suggested that the absorption process of phenol red from rat liver surface does not approach saturability. The time course of the remaining amount of phenol red in the glass cell obeyed first-order kinetics at a dose of 0·3 mg, and its rate constant Ka was calculated to be 0·0069 min?1. Moreover, no significant difference was seen in the Ka value within the dose range of 0·3-3 mg, which was estimated by curve fitting of the plasma concentration profile of phenol red after application to rat liver surface in the two-compartment model with first-order absorption. 2,4-Dinitrophenol (0·3 mg) and probenecid (0·5 and 1 mg), inhibitors of metabolic energy and anion transport, respectively, had no significant effect on the pharmacokinetics of phenol red after application to rat liver surface. These data demonstrate that a specific transport mechanism such as active transport is not involved in phenol red absorption from rat liver surface membrane. 相似文献
102.
MASATO KIRIYAMA SHIGEKI TAKASHIMA HIROYUKI SAHARA YOSHIYUKI KUROSAKA MASAHIRO MATSUSHITA TAKAYOSHI AKIYAMA FUJIO TOMITA HITOSHI SAITO TAKEO KOSAKA ICHIRO KITA YASUHIKO KOJIMA SHIGERU TAKEGAWA 《Journal of gastroenterology and hepatology》1996,11(7):626-629
We present a case of portal-systemic encephalopathy due to a congenital splenorenal shunt. A 69 year old woman was admitted to hospital because of recurrent episodes of disturbed consciousness. The present episode had begun 3 months prior to admission. Although the patient demonstrated mildly slurred speech, the remainder of her neurological examination was unremarkable. She showed no clinical signs of portal hypertension and her liver function, except for a serum hepaplastin test of 58% and an ICG retention rate of 28% at 15 min, was normal. Her serum ammonium level was 210 μg/dL. The venous phase of a superior mesenteric arteriogram revealed a splenorenal shunt and narrowing of the portal vein, which was 4 mm in diameter. The histological findings, demonstrated by a needle liver biopsy specimen, were consistent with mild fibrosis and lymphocytic infiltration. Following the diagnosis of a splenorenal shunt in the absence of liver cirrhosis, ligature of the shunt was performed with a splenectomy. The portal vein pressure after ligature of the shunt rose from 12.5 to 18.8 mmHg. This shunt was thought to be of congenital origin. The high preoperative serum ammonia concentration decreased to the normal range postoperatively and the serum hepaplastin test and ICG retention rate similarly improved postoperatively. A follow-up superior mesenteric arteriogram was performed during the venous phase, demonstrating resolution of the shunt and decreased portal vein narrowing. The patient has suffered no further episodes of disturbed consciousness postoperatively. 相似文献
103.
YOSHIKO MIYAOKA md HITOSHI MIYAOKA md TETSUYA MOTOMIYA md SHIN-ICHI KITAMURA md MASAHIRO ASAI md 《Psychiatry and clinical neurosciences》1997,51(4):203-206
Abstract One hundred and fifty-one non-insulin-dependent diabetic patients were assessed to detect sociodemographic, psychological and disease-related characteristics that were related to depressive state among diabetic patients. Depressive state in the patients was correlated with poor social support and low economic status, premorbid neurotic personality and the presence of complications, retinopathy in particular. However, depressive state did not correlate with age, gender, education, serum level of HbA1C or duration of diabetes. The severity of the depressive state in diabetic patients may vary with the cultural background of the patient and/or the country in which he or she is living. In treating diabetic patients, doctors need to pay special attention to these factors. 相似文献
104.
MASAOMI CHINUSHI YOSHIFUSA AIZAWA KAZUYOSHI TAKAHASHI OHIRA KOUJI HITOSHI KITAZAWA TAKASHI WASHIZUKA AKIRA ABE AKIRA SHIBATA 《Pacing and clinical electrophysiology : PACE》1997,20(2):325-336
RF catheter ablation was performed in 16 patients with nonreentrant idiopathic VT originating from the RVOT. All documented VT was monomorphic, but subtle morphological variation in the VT-QRS complex was observed in 10 (63%) of 16 patients. Through endocardial mapping, VT origin was determined within a narrow site (< 0.5 ± 0.5 cm) in 4 of the 10 patients with the morphological variation. In the other 6 of 10 patients, the origin extended to an area of > 0.5 ± 0.5 cm. In VT with morphological variation, the local electrogram at the site of VT origin also showed variation in morphology and activation sequence. For VT of narrow origin, RF application to the site eliminated the VT. However, in VT from a wide arrhythmogenic area, RF current had to be delivered to 3–7 distinct sites to cover the possible origin, and specific QRS configuration of VT and/or PVC was ablated at each of the earliest activation site. All but one VT were successfully ablated by RF current. Subtle morphological variation was frequent in this type of VT, and about half were associated with a wide arrhythmogenic area. Precise mapping and analysis of the efficacy of each BF application might be helpful to better understand the relationship between subtle changes of VT-QRS morphology and their origins. 相似文献
105.
SUZUKI HISAMITSU; KAWASHIMA KOHEI; YAMADA KAZUMASA; MINAMI SABURO; KATO YUKIO; TANIMOTO MITSUNE; YAMADA HIRONORI; ISOBE KENICHI; HAYASHI KIYOTAKA; YAMAGUCHI HIROSHI; TAKAMATSU JUNKI; WATANABE EIJI; KODERA YOSHIHISA; SHIKU HIROSHI; KAMIYA TADASHI; OHNO RYUZO; MORISHITA HIROSHI; YOKOMAKU SHOZO; YOSHIDA KAZUKO; OGURA MICHINORI 《Japanese journal of clinical oncology》1980,10(1):111-118
Eight patients with acute nonlymphocytic leukemia (ANLL) andfive patients with acute lymphocytic leukemia were treated withaclacinomycin A. It was given daily by one-hour infusion indoses ranging from 0.33 to 0.70 mg/kg for seven to 20 days withoutother antileukemic agents. Two patients with ANLL achieved completeremission and one with ANLL achieved partial remission. Itsmajor toxic effects were myelosuppression and gastrointestinalsymptoms. 相似文献
106.
HIROSHI OKADA HITOSHI FUJIOKA NOBORU TATSUMI MASANORI KANZAKI YOKO INABA MASATO FUJISAWA KAZUO GOHJI SOICHI ARAKAWA SADAO KAMIDONO 《The Journal of urology》1998,159(3):848-850
Purpose
We determined a rational strategy for treatment of patients with retrograde ejaculation in the era of modern assisted reproduction technology.Materials and Methods
In 7 consecutive patients medical treatment or retrieval of spermatozoa from the bladder was performed at a male infertility clinic.Results
Antegrade ejaculation was restored in 3 patients, and spermatozoa were retrieved from the bladder and used for assisted reproduction in 3. Spermatozoa with good oolemma penetrating ability were collected by seminal vesicle massage.Conclusions
Modern assisted reproduction technology is a powerful treatment option for retrograde ejaculation when combined with a technique to retrieve spermatozoa of good quality from the bladder. 相似文献107.
DETERMINATIONS OF ETHANOL, ACETALDEHYDE AND ACETATE IN BLOOD AND URINE DURING ALCOHOL OXIDATION IN MAN 总被引:2,自引:0,他引:2
TSUKAMOTO SHOJIRO; MUTO TORU; NAGOYA TADAAKI; SHIMAMURA MASAO; SAITO MAKOTO; TAINAKA HITOSHI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1989,24(2):101-108
Blood and urine samples were analyzed for ethanol, acetaldehydeand acetate during alcohol oxidation in Japanese men by headspace gas chromatography, following the consumption of 16 ml/kgof beer during a 20 min period. The maximum level of blood/urineethanol was found to be 1517 mM (2022 mM), whilethat of acetaldehyde in a flusher and in non-flushers was 20µM (52 µM) and 25 µM (1013 µM),respectively. Acetate levels in these groups ranged from 0.2mM (0.1 mM) to 0.8 mM (1.0 mM). Blood ethanol levels were dosedependent, whereas acetaldehyde and acetate levels reflectedindividual metabolic rates. The relative concentrations of ethanoland acetaldehyde in blood and that of acetate in alcohol metabolismcould be summarized as follows: 7500 (15 mM): 13 (25µM); 250400 (0.50.8 mM) for non-flushers;and 7500 (15 mM): 510 (1020 µM): 250400(0.50.8 mM) for a flusher. 相似文献
108.
109.
110.
Prospective Evaluation of Bilateral Diaphragmatic Electromyograms During Cryoballoon Ablation of Atrial Fibrillation
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