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KAORU SHIDA MUNEAKI MATSUO TADASHI SATO YASUFUMI MAEDA HAKARU TASAKI SUMIO MIYAZAKI 《Pediatrics international》1996,38(3):270-273
Reported is a case of hemorrhagic shock and encephalopathy syndrome (HSE) with extensive white matter involvement. A three year old, previously healthy boy was presented with an acute onset of fever, loss of consciousness and convulsions. He had disseminated intravascular coagulation, metabolic acidosis, non-ketotic hypoglycemia and hepatorenal dysfunction. The computed tomography (CT) scan of his head on the second day of illness demonstrated symmetric, extensive low-density areas in the cerebral and cerebellar white matter. The child died on the 13th hospital day. A post-mortem histopathological examination of the liver revealed centrilobular necrosis and infiltration of fatty acid droplets. The concentrations of serum 2′,5′-oligoadenylate synthetase and urinary neopterin were markedly elevated, indicating excessively activated cell-mediated immunity. This overproduction of inflammatory cytokines might play an important role in the pathogenesis of the brain lesion as well as in other clinical and laboratory manifestations. The patient had a decreased serum level of α1-antitrypsin, which may have been associated with the development of uncontrolled inflammation and coagulation disorder. 相似文献
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Stria vascularis as source of endocochlear potential 总被引:6,自引:0,他引:6
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KAZUMARU WADA md KAZUHIRO KIRYU md YUKO KAWATA md TAKESHI CHIBA md KAZUHISA MIZUNO md MOTOHIRO OKADA md HIROICHI TASAKI md YUTAKA FUKUSHIMA md FUMIO SAITO md SUNAO KANEKO md 《Psychiatry and clinical neurosciences》1997,51(4):233-235
Abstract Of the epileptic patients who were treated for ≥ 5 years until the end of 1990 and had more than four seizures in 1990, 63 patients had been treated without interruption until the end of 1995. We analyzed their clinical courses from 1990 to 1995 prospectively. More than half the subjects were diagnosed with temporal lobe epilepsy. Twenty cases had presumed etiology, and 32 had neuropsychiatric complications. Of the subjects whose seizures were not controlled with conventional antiepileptic drugs (AED), 11 cases demonstrated significant improvement when new AED; that is, lamotrigine, vigabatrin, clobazam, topiramate, tiagabine or CGP33101 were added. However, 10 patients did not respond to new AED. Presumed etiology, neuropsychiatric complications, multiple epileptic foci in EEG and abnormalities on head CT or MRI were characteristics of the patients whose seizures were resistant to new AED. 相似文献