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641.
John M. Salsman Jin-Shei Lai Hugh C. Hendrie Zeeshan Butt Nicholas Zill Paul A. Pilkonis Christopher Peterson Catherine M. Stoney Pim Brouwers David Cella 《Quality of life research》2014,23(1):205-215
Objective
Psychological well-being (PWB) has a significant relationship with physical and mental health. As a part of the NIH Toolbox for the Assessment of Neurological and Behavioral Function, we developed self-report item banks and short forms to assess PWB.Study design and setting
Expert feedback and literature review informed the selection of PWB concepts and the development of item pools for positive affect, life satisfaction, and meaning and purpose. Items were tested with a community-dwelling US Internet panel sample of adults aged 18 and above (N = 552). Classical and item response theory (IRT) approaches were used to evaluate unidimensionality, fit of items to the overall measure, and calibrations of those items, including differential item function (DIF).Results
IRT-calibrated item banks were produced for positive affect (34 items), life satisfaction (16 items), and meaning and purpose (18 items). Their psychometric properties were supported based on the results of factor analysis, fit statistics, and DIF evaluation. All banks measured the concepts precisely (reliability ≥0.90) for more than 98 % of participants.Conclusion
These adult scales and item banks for PWB provide the flexibility, efficiency, and precision necessary to promote future epidemiological, observational, and intervention research on the relationship of PWB with physical and mental health. 相似文献642.
643.
Rianne Jahja Francjan J. van Spronsen Leo M. J. de Sonneville Jaap J. van der Meere Annet M. Bosch Carla E. M. Hollak M. Estela Rubio-Gozalbo Martijn C. G. J. Brouwers Floris C. Hofstede Maaike C. de Vries Mirian C. H. Janssen Ans T. van der Ploeg Janneke G. Langendonk Stephan C. J. Huijbregts 《Journal of inherited metabolic disease》2016,39(3):355-362
Objective
Early treatment of phenylketonuria (ET-PKU) prevents mental retardation, but many patients still show cognitive and mood problems. In this study, it was investigated whether ET-PKU-patients have specific phenylalanine (Phe-)related problems with respect to social-cognitive functioning and social skills.Methods
Ninety five PKU-patients (mean age 21.6?±?10.2 years) and 95 healthy controls (mean age 19.6?±?8.7 years) were compared on performance of computerized and paper-and-pencil tasks measuring social-cognitive abilities and on parent- and self-reported social skills, using multivariate analyses of variance, and controlling for general cognitive ability (IQ-estimate). Further comparisons were made between patients using tetrahydrobiopterin (BH4, N?=?30) and patients not using BH4. Associations with Phe-levels on the day of testing, during childhood, during adolescence and throughout life were examined.Results
PKU-patients showed poorer social-cognitive functioning and reportedly had poorer social skills than controls (regardless of general cognitive abilities). Quality of social-cognitive functioning was negatively related to recent Phe-levels and Phe-levels between 8 and 12 years for adolescents with PKU. Quality of social skills was negatively related to lifetime phenylalanine levels in adult patients, and specifically to Phe-levels between 0 and 7, and between 8 and 12 years. There were no differences with respect to social outcome measures between the BH4 and non-BH4 groups.Conclusion
PKU-patients have Phe-related difficulties with social-cognitive functioning and social skills. Problems seem to be more evident among adolescents and adults with PKU. High Phe-levels during childhood and early adolescence seem to be of greater influence than current and recent Phe-levels for these patients.644.
645.
Fiebrich HB van Asselt SJ Brouwers AH van Dullemen HM Pijl ME Elsinga PH Links TP de Vries EG 《Critical reviews in oncology/hematology》2012,82(2):213-226
Pancreatic islet cell tumors are neuroendocrine tumors, which can produce hormones and can arise as part of multiple endocrine neoplasia type 1 or von-Hippel-Lindau-disease, two genetically well-defined hereditary cancer syndromes. Currently, technical innovation improves conventional and specific molecular imaging techniques. To organize the heterogeneous results described for the imaging of these tumors, we distinguished three indications (1) imaging of a patient with hormone hypersecretion, (2) search for a pancreatic primary in case of proven neuroendocrine cancer of unknown primary, and (3) screening of asymptomatic mutation carriers. We searched for publications on imaging of islet cell tumors between 1995 and January 2010 and defined a Level of Evidence (LOE) for the applicability of each technique. For each technique, data were analyzed in a Forest plot and arranged per imaging indication and tumor subtype. LOEs are weak for all imaging techniques. Analyses indicate a prominent role for endoscopic ultrasound for all three indications. 相似文献
646.
647.
Joseph G. Timmons MBChB Nicola Greenlaw MSc James G. Boyle FRCP Nish Chaturvedi MD Ian Ford PhD Martijn C. G. J. Brouwers MD Therese Tillin MBBS Irene Hramiak MD Alun D. Hughes MD Alicia J. Jenkins MD Barbara E. K. Klein MD Ron Klein MD Teik C. Ooi MBBS Peter Rossing MD Coen D. A. Stehouwer MD Naveed Sattar MD Helen M. Colhoun MD John R. Petrie FRCP for the REMOVAL Study Group 《Diabetes, obesity & metabolism》2021,23(6):1371-1378
648.