全文获取类型
收费全文 | 6162篇 |
免费 | 586篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 298篇 |
妇产科学 | 171篇 |
基础医学 | 786篇 |
口腔科学 | 124篇 |
临床医学 | 480篇 |
内科学 | 1261篇 |
皮肤病学 | 168篇 |
神经病学 | 1023篇 |
特种医学 | 399篇 |
外国民族医学 | 2篇 |
外科学 | 521篇 |
综合类 | 145篇 |
现状与发展 | 1篇 |
预防医学 | 701篇 |
眼科学 | 48篇 |
药学 | 322篇 |
肿瘤学 | 281篇 |
出版年
2023年 | 59篇 |
2021年 | 73篇 |
2020年 | 76篇 |
2019年 | 76篇 |
2018年 | 96篇 |
2017年 | 80篇 |
2016年 | 92篇 |
2015年 | 102篇 |
2014年 | 125篇 |
2013年 | 178篇 |
2012年 | 290篇 |
2011年 | 265篇 |
2010年 | 167篇 |
2009年 | 133篇 |
2008年 | 259篇 |
2007年 | 291篇 |
2006年 | 243篇 |
2005年 | 241篇 |
2004年 | 246篇 |
2003年 | 227篇 |
2002年 | 214篇 |
2001年 | 181篇 |
2000年 | 167篇 |
1999年 | 152篇 |
1998年 | 79篇 |
1997年 | 57篇 |
1996年 | 49篇 |
1995年 | 56篇 |
1994年 | 52篇 |
1993年 | 67篇 |
1992年 | 167篇 |
1991年 | 142篇 |
1990年 | 135篇 |
1989年 | 156篇 |
1988年 | 154篇 |
1987年 | 138篇 |
1986年 | 121篇 |
1985年 | 116篇 |
1984年 | 114篇 |
1983年 | 86篇 |
1982年 | 59篇 |
1981年 | 56篇 |
1980年 | 56篇 |
1979年 | 89篇 |
1977年 | 71篇 |
1975年 | 47篇 |
1974年 | 64篇 |
1973年 | 69篇 |
1971年 | 47篇 |
1969年 | 52篇 |
排序方式: 共有6766条查询结果,搜索用时 15 毫秒
41.
Ross BD; Jacobson S; Villamil F; Korula J; Kreis R; Ernst T; Shonk T; Moats RA 《Radiology》1994,193(2):457
42.
This report will discuss the different aspects of long-term steroid therapy. The five major areas of interest are indications for treatment, complications, withdraw, monitoring, and surgical adjustment of dosage. 相似文献
43.
44.
Daily administration of a drug in a distinctive environment establishes contingencies that support Pavlovian conditioning. Environmental cues that are paired with the drug injection and that predict the onset of drug action can become conditioned stimuli. Ultimately, the conditioned stimuli come to predict the availability of drug and develop the potential to engender conditioned drug responses. Various psychostimulant drugs can produce conditioned locotnotion when tested in the presence of environmental cues that were repeatedly associated with the drug experience. The ability of amphetamine and cocaine to produce conditioned locomotion was demonstrated in the present study. Stimulant-like properties of methylenedioxymethamphetamine (MDMA) have been reported in locomotor paradigms, drug discrimination procedures, and human subjective questionnaires. MDMA (5 mg/kg), paired for 5 days to a distinct environment signalled by the presence of a distinct odor, produced enhanced locomotion during a test probe with the odor alone indicating that MDMA can also produce conditioned locomotion. The observation that the stimulus properties of MDMA can also become associated with environmental cues supports the hypothesis that some of the behavioral effects of MDMA resemble those of other classical psychostimulants such as amphetamine and cocaine.This is publication number 5732BCR from the Research Institute of Scripps Clinic 相似文献
45.
Nicholas J Laping Jeffrey I Everitt Kendall S Frazier Mark Burgert Melisa J Portis Caprice Cadacio Leslie I Gold Cheryl L Walker 《Clinical cancer research》2007,13(10):3087-3099
PURPOSE: Transforming growth factor beta (TGF-beta), which generally stimulates the growth of mesenchymally derived cells but inhibits the growth of epithelial cells, has been proposed as a possible target for cancer therapy. However, concerns have been raised that whereas inhibition of TGF-beta signaling could be efficacious for lesions in which TGF-beta promotes tumor development and/or progression, systemic pharmacologic blockade of this signaling pathway could also promote the growth of epithelial lesions. EXPERIMENTAL DESIGN: We examined the effect of a TGF-beta inhibitor on mesenchymal (leiomyoma) and epithelial (renal cell carcinoma) tumors in Eker rats, which are genetically predisposed to develop these tumors with a high frequency. RESULTS: Blockade of TGF-beta signaling with the ALK5/type I TGF-beta R kinase inhibitor, SB-525334, was efficacious for uterine leiomyoma; significantly decreasing tumor incidence and multiplicity, and reducing the size of these mesenchymal tumors. However, SB-525334 was also mitogenic and antiapoptotic for epithelial cells in the kidney and exacerbated the growth of epithelial lesions present in the kidneys of these animals. CONCLUSION: Although pharmacologic inhibition of TGF-beta signaling with SB-525334 may be efficacious for mesenchymal tumors, inhibition of this signaling pathway seems to promote the development of epithelial tumors. 相似文献
46.
47.
Robert A. Hauser F. Reed Murtaugh Kauser Akhter Michael Gold C. W. Olanow 《Journal of neuroimaging》1996,6(4):222-226
Corticobasal degeneration (CBD) is an adult–onset, progressive parkinsonian syndrome with strikingly asymmetrical features, and signs and symptoms referable to both cerebral cortex and basal ganglia. Although once considered rare, it is now recognized with increasing frequency during life. Eight patients with clinically diagnosed CBD and 8 age– and sex–matched patients with Parkinson's disease underwent high–field–strength magnetic resonance imaging (MRI) of the brain. MRIs were graded by a blinded neuroradiologist using a semiquantitative (0–3) scale. MRI of patients with CBD revealed significantly greater T2–weighted signal hypointensity in the putamena and globi pallidi, and ventricular enlargement. When specifically sought, asymmetrical cortical atrophy was identified in 5 of 8 CBD patients. Increased T2–weighted lenticular signal hypointensity, ventricular enlargement, and asymmetrical cortical atrophy are supportive MRI findings of CBD. 相似文献
48.
The purpose of this paper is to draw attention to the ability of some antipsychotic agents to produce sustained erection short of priapism. They appear to have this effect consistently over time in some individuals. The effect is rapidly reversible on discontinuation of the drug, and appears to be dose-dependent. In one of our patients, the "active metabolite" of that same drug could not duplicate the effect. Prevalence and mechanism require clarification. If even a small proportion of patients with the sustained erection phenomenon are found to progress to priapism, this would have profound ramifications. If this phenomenon could be confidently predicted or safely and readily implemented, the benefits for some patients with impotence or premature ejaculation might be considerable. Given all the potential adverse side effects of antipsychotics, it should be appreciated that the potential direct effects on male sexual function are not always adverse. 相似文献
49.
Reconstruction of axillary burn contractures with the latissimus dorsi fasciocutaneous flap 总被引:1,自引:0,他引:1
Standard management of axillary burn contractures has been scar release and the use of skin grafts, despite the common problem of incomplete graft take, prolonged splinting, extended physical therapy, and recurrent contractures. A recent development in plastic surgery has been the "super flap" or fasciocutaneous flap. A series of axillary burn contractures released with the latissimus dorsi fasciocutaneous flap has been reported by Tolhurst. Our series of ten patients confirms that the latissimus dorsi fasciocutaneous flap is the treatment of choice for the release of severe axillary burn contractures. 相似文献
50.
Indoor air pollution. 总被引:1,自引:0,他引:1
D R Gold 《Clinics in Chest Medicine》1992,13(2):215-229
This article summarizes the health effects of indoor air pollutants and the modalities available to control them. The pollutants discussed include active and passive exposure to tobacco smoke; combustion products of carbon monoxide; nitrogen dioxide; products of biofuels, including wood and coal; biologic agents leading to immune responses, such as house dust mites, cockroaches, fungi, animal dander, and urine; biologic agents associated with infection such as Legionella and tuberculosis; formaldehyde; and volatile organic compounds. An approach to assessing building-related illness and "tight building" syndrome is presented. Finally, the article reviews recent data on hospital-related asthma and exposures to potential respiratory hazards such as antineoplastic agents, anesthetic gases, and ethylene oxide. 相似文献