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91.
Chloé Dussaux Marie-Victoire Senat Hanane Bouchghoul Alexandra Benachi Laurent Mandelbrot Gilles Kayem 《The journal of maternal-fetal & neonatal medicine》2018,31(17):2284-2292
Background: Preterm prelabor rupture of membranes is a frequent obstetric condition associated with increased risks of maternal and neonatal morbidity and mortality. Conventional management is in hospital. Outpatient management is an alternative in selected cases; however, the safety of home management has not been established.Objective: To study the obstetric and neonatal outcomes of women with preterm premature rupture of membranes between 24 and 34 weeks who were managed as outpatient (outpatient care group), compared with those managed in hospital (hospital care group).Study design: A retrospective cohort study between 1 January 2009 and 31 December 2013 in three French tertiary care centers.Results: Ninety women were included in the outpatient care group and 324 in the hospital care group. In the outpatient care group, the gestational age at membrane rupture was lower, compared to the hospital care group (28.8 (26.6–30.5) vs. 30.3 (27.6–32.1) weeks; p?.01) and the cervical length at admission was higher (31.7?±?10.4 vs. 24.3?±?11.8?mm; p?.01). In the outpatient care group, no delivery or major obstetric complication occurred at home.Conclusion: We observed no major complication related to home care after a period of observation. A randomized study would be necessary to confirm its safety. 相似文献
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A phase I window,dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine,dexamethasone, PEG‐asparaginase,and doxorubicin
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93.
Philippe Voruz Alexandre Cionca Isabele Jacot de Alcntara Anthony NuberChampier Gilles Allali Lamyae Benzakour Patrice H. Lalive Karl O. Lvblad Olivia Braillard Mayssam Nehme Matteo Coen Jacques Serratrice JeanLuc Reny Jrme Pugin Idris Guessous Radek Ptak Basile N. Landis Dan Adler Alessandra Griffa Dimitri Van De Ville Frdric Assal Julie A. Pron 《Human brain mapping》2023,44(4):1629
Neuropsychological deficits and brain damage following SARS‐CoV‐2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological and olfactory tests, as well as completed psychiatric and respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients underwent functional magnetic resonance imaging. Patients in the severe group displayed poorer verbal episodic memory performances, and moderate patients had reduced mental flexibility. Neuroimaging revealed patterns of hypofunctional and hyperfunctional connectivities in severe patients, while only hyperconnectivity patterns were observed for moderate. The default mode, somatosensory, dorsal attention, subcortical, and cerebellar networks were implicated. Partial least squares correlations analysis confirmed specific association between memory, executive functions performances and brain functional connectivity. The severity of the infection in the acute phase is a predictor of neuropsychological performance 6–9 months following SARS‐CoV‐2 infection. SARS‐CoV‐2 infection causes long‐term memory and executive dysfunctions, related to large‐scale functional brain connectivity alterations. 相似文献
94.
Gilles Houvenaeghel Alexandre de Nonneville Guillaume Blache Max Buttarelli Camille Jauffret Djamel Mokart Laura Sabiani 《Journal Of Gynecologic Oncology》2022,33(3)
ObjectivePosterior pelvic exenteration (PPE) can be required to achieve complete resection in ovarian cancer (OC) patients with large pelvic disease. This study aimed to analyze morbidity, complete resection rate, and survival of PPE.MethodsNinety patients who underwent PPE in our Comprehensive Cancer Center between January 2010 and February 2021 were retrospectively identified. To analyze practice evolution, 2 periods were determined: P1 from 2010 to 2017 and P2 from 2018 to 2021.ResultsA 82.2% complete resection rate after PPE was obtained, with rectal anastomosis in 96.7% of patients. Complication rate was at 30% (grade 3 in 9 patients), without significant difference according to periods or quality of resection. In a binary logistic regression adjusted on age and stoma, only age of 51–74 years old was associated with a lower rate of complication (odds ratio=0.223; p=0.026). Median overall and disease-free survivals (OS and DFS) from initial diagnosis were 75.21 and 29.84 months, respectively. A negative impact on OS and DFS was observed in case of incomplete resection, and on DFS in case of final cytoreductive surgery (FCS: after ≥6 chemotherapy cycles). Age ≥75-years had a negative impact on DFS for new OC surgery. For patients with complete resection, OS and DFS were decreased in case of interval cytoreductive surgery and FCS in comparison with primary cytoreductive surgery.ConclusionPPE is an effective surgical measure to achieve complete resection for a majority of patients. High rate of colorectal anastomosis was achieved without any mortality, with acceptable morbidity and high protective stoma rate. 相似文献
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Bozec Alexandre Schultz Philippe Gal Jocelyn Chamorey Emmanuel Chateau Yann Dassonville Olivier Poissonnet Gilles Peyrade Frédéric Saada Esma Guigay Joël Benezery Karen Leysalle Axel Santini Laure Giovanni Antoine Messaoudi Lila Fakhry Nicolas 《European archives of oto-rhino-laryngology》2019,276(9):2531-2539
European Archives of Oto-Rhino-Laryngology - Providing cancer patients with adequate information is essential to their confidence and satisfaction regarding medical care. The aims of this study... 相似文献
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