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101.
102.
Barboi Alexandru Gibbons Christopher H. Bennaroch Eduardo E. Biaggioni Italo Chapleau Mark W. Chelimsky Gisela Chelimsky Thomas Cheshire William P. Claydon Victoria E. Freeman Roy Goldstein David S. Joyner Michael J. Kaufmann Horacio Low Phillip A. Norcliffe-Kaufmann Lucy Robertson David Shibao Cyndya A. Singer Wolfgang Snapper Howard Vernino Steven Raj Satish R. 《Clinical autonomic research》2020,30(2):183-184
Clinical Autonomic Research - 相似文献
103.
Andrew P. Cope Deena Gibbons Fionula M. Brennan Marc Feldmann Dan Aderka Michael Doherty Adrian C. Jones Hartmut Engelmann David Wallach Ravinder N. Maini 《Arthritis \u0026amp; Rheumatology》1992,35(10):1160-1169
Objective. Recently, 2 classes of cytokine inhibitors have been defined at the molecular level. The largest group comprises the extracellular domains of cell surface cytokine receptors, and includes both tumor necrosis factor receptors (TNF-R). The present study was conducted to investigate the role of TNF inhibitors in arthritis. Methods. We measured p55 and p75 soluble TNF-R (sTNF-R) in serum and synovial fluid (SF) samples from patients with rheumatic diseases and compared their levels with levels of soluble interleukin-2 receptors (sIL-2R). Sensitive enzyme-linked immunosorbent assays (ELISA), specific for p55 and p75 sTNF-R and for sIL-2R, were used. Results. Serum levels of p75 sTNF-R were 3–4-fold higher than levels of p55 sTNF-R, and both were significantly elevated in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) compared with healthy controls. RA SF levels of sTNF-R were 4–5-fold higher than levels in serum, suggesting local production in the joint, and were significantly higher than levels in the SF of patients with seronegative arthropathy or OA. Furthermore, levels of p55 and p75 sTNF-R, but not sIL-2R or TNFα measured by ELISA, were increased in the SF of patients with clinically active RA. The soluble TNF-R in RA and OA SF were functional since they inhibited TNF activity in a cytotoxicity assay in proportion to the levels of inhibitor present. Evaluation of serially obtained serum samples suggested that sTNF-R may be a useful parameter for monitoring RA disease activity. Conclusion. Biologically active soluble TNF-R are up-regulated in patients with rheumatic disease and are produced locally in the joints. Measurement of serum levels of TNF-R may be useful for monitoring of disease, and determination of SF levels could be of diagnostic value. 相似文献
104.
Eleanor H. Wertheim Susan J. Paxton Dana Maude George I. Szmukler Kay Gibbons Lynne Hillier 《The International journal of eating disorders》1992,12(2):151-160
This study examined the predictors of dieting, extreme weight loss behaviors, and binge eating in adolescents (606 females and 315 males). High school classes were administered measures of weight loss behaviors, binge eating, perceived current and ideal body size, body dissatisfaction, advantages of being thinner and physically fitter, satisfaction with fitness, depression, self-esteem, parental overprotection, parental caring, and family adaptability and cohesion. Principal component analyses grouped predictor (body image, psychosocial) and criterion (weight loss behaviors, binge eating) variables. The primary predictor of weight loss behaviors in both sexes and binge eating in girls was the desire to be thinner which included a larger current body size. Psychological and family variables played lesser roles but were significantly predictive in a number of cases. Sex differences in factor structures and important predictors emerged. © 1992 John Wiley & Sons, Inc. 相似文献
105.
This study was designed to explore the possibility that Bandura's notion of self-efficacy can be applied to control over cognitions as well as behavior. Subjects were asked to complete questionnaires designed to measure their dental anxiety, the number of their negative self-statements about a dental appointment and their perceived ability to control these thoughts. Subjects with low anxiety claimed to experience fewer negative thoughts than those with moderate or high anxiety, and also to have more control over these thoughts. Subjects believed that the extent of their control would decline as the appointment approached in time, but least for the low anxiety group and most for the high anxiety group. Finally, differences in self-efficacy scores between anxiety groups were maintained when the number of negative thoughts was controlled for, but differences in negative thinking between anxiety levels were not maintained when self-efficacy was controlled for. These results suggest that anxiety is more closely related to thinking processes than content. 相似文献
106.
M P Learmonth M R Euerby D E Jacobs W A Gibbons 《Molecular and biochemical parasitology》1987,25(3):293-298
One- and two-dimensional proton (1H) nuclear magnetic resonance (NMR) spectroscopic techniques have yielded detailed in vitro profiles of the metabolites present in the parasitic nematode Toxocara canis. The major intracellular metabolites were found to include trehalose, alanine, succinate, acetate, propionate and alpha-glycerophosphorylcholine. 相似文献
107.
B Czepulkowski B Gibbons J Tucker J Amess T A Lister 《Cancer Genetics and Cytogenetics》1987,25(1):175-177
A 34-year-old man with refractory anemia with excess blasts in transformation is reported, having a t(8;21) translocation and a duplication of one of the products, der(21). The duplicated product had not been observed at presentation in malignant disease, as far as we are aware; thus, the findings are discussed with regard to this case and other possible smoldering leukemias. The diagnostic use of cytogenetics is also considered. 相似文献
108.
P A Stonebridge A I Tsoukas F B Pomposelli G W Gibbons D R Campbell D V Freeman A Miller F W LoGerfo 《European journal of vascular surgery》1991,5(3):265-269
Between January 1984 and August 1989, 117 diabetic patients with a palpable popliteal pulse but distal limb threatening ischaemia underwent 124 popliteal artery (or below) to distal bypass grafts. All grafts were intra-operatively monitored. The operative mortality was 0.8% and the 30 day primary patency 93%. Primary patencies at 1 and 3 years were 88.6 and 85.2%, respectively. The results of using the popliteal artery as the proximal graft inflow site in diabetes are comparable to other patient groups and to alternative more proximal inflow sites, but require a shorter length of vein graft with a shorter vein harvesting incision, avoid groin disection and result in a more peripheral operation. 相似文献
109.
Over a 3 1/2 year period, 55 limbs were revascularized with in situ saphenous vein bypass grafts in 49 patients. Ninety-five percent of grafts were constructed in patients with critical ischemia for limb salvage, and 5 percent were constructed for debilitating claudication. The proximal anastomosis was performed in the groin in all patients. The distal graft was taken to the popliteal artery in 45 percent and to a tibial or isolated popliteal segment in 55 percent, with 55 percent of the grafts having single-vessel runoff. The perioperative mortality rate was 7 percent. The primary immediate patency rate was 91 percent and the secondary immediate patency rate was 98 percent at 1 month. The cumulative patency rate at 42 months was 85.4 percent overall, 86.6 percent for the tibial grafts, and 84 percent for the popliteal grafts. The cumulative limb salvage rate was 100 percent for the popliteal grafts, 90 percent for the tibial grafts, and 94.5 percent overall. All of the patients were followed and 3 required secondary revision. In situ vein bypass is a technically demanding procedure that can be performed successfully in high-risk patients with limbs with minimal runoff and can yield very high long-term patency and limb salvage rates in a community hospital setting. 相似文献
110.
James H. O’Keefe Cindy L. Grines Marcus A. DeWood Timothy M. Bateman Timothy F. Christian Raymond J. Gibbons 《Journal of nuclear cardiology》1995,2(1):35-41