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41.
R F Boswell W J Welstead R L Duncan D N Johnson W H Funderburk 《Journal of medicinal chemistry》1978,21(1):136-139
In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action. 相似文献
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Evaluation of nipple discharge in benign and malignant diseases 总被引:1,自引:0,他引:1
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There is a need to advance the quality of healthcare by increasing knowledge about multiple risk factors and how to intervene
to improve health outcomes. In an effort to better describe the presentation of multiple risks, this study involved a database
review to describe the prevalence and covariation of multiple risk factors in individuals presenting to primary care. Patients
with a primary care encounter from January 1, 2005 to June 30, 2005 (N = 10,043) were identified from the Department of Veteran’s Affair’s medical database and information about the following
risk factors was extracted: alcohol use, psychiatric distress, body mass, smoking status, blood pressure, and posttraumatic
stress. Exploratory and confirmatory latent class analyses identified three classes of individuals. Class 1 consisted of individuals
with an overall lower level of risk for health problems, but a moderately high likelihood of elevated blood pressure. Individuals
in Class 2 appeared to have the greatest need for intervention because they had a moderate to high likelihood of reporting
at risk alcohol use, smoking, depression, and posttraumatic stress. Class 3 consisted of individuals reporting the co-occurrence
of at risk alcohol use, smoking, and elevated blood pressure. Similar to past research, the findings highlight the need for
addressing multiple risk factors in primary care. In addition, this study expands on the literature by identifying specific
patterns of covariation among different risk factors that suggest avenues for research and program development.
All authors have contributed equally to this work. 相似文献
48.
Quality of life is a fascinating field to researchers and practitioners alike. To some researchers, quality of life is of interest because it offers untold challenges in constructing instruments and capturing data necessary to answer key questions about health, disease, and treatment. For such researchers, quality of life is about statistical relationships among questions and about using questions to define the physical, social, and emotional domains of health. To other researchers, this field is about finding practical applications in policy and treatment decision making for the information provided by quality of life assessments. To these researchers, the focus of quality of life is on ways to apply knowledge of quality of life differences between groups with and without specific diseases or ways to use knowledge about how treatments affect the quality of life of various patient populations. To practitioners, quality of life is about treatment outcomes that impact individual patients' daily lives. It is the practitioner that Funderburk, Pleil, and Pathak are considering in their paper in this issue of Pharmacy Practice Management Quarterly. These authors give several important messages to practitioners seeking to serve their patients by incorporating quality of life into their practices. The key message in the paper is that to better understand and determine the impact of treatment on a patient's quality of life, it is critical to start with a baseline or reference point relevant to that patient. From that baseline or reference point, treatment decisions can be made and progress, in quality of life terms, can be evaluated. Critical questions in their framework, which is called the IN*COMPASS (Individualized Client Oriented Method for Preferred Alleviation of Sickness States) Approach, are "How are you now?" and "How would you like to be?" The authors do not endorse particular quality of life tools in their approach; rather they prescribe certain critical questions that must be answered if information captured by any quality of life tool is to be useful at the patient level. Readers should not be put off by the fancy acronym used in this paper; nor must readers be keen students of quality of life to appreciate its message. The IN*COMPASS approach is fundamental to good patient care and can be applied by practitioners with any level of understanding of and appreciation for quality of life assessments. 相似文献
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