全文获取类型
收费全文 | 9573篇 |
免费 | 563篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 124篇 |
儿科学 | 158篇 |
妇产科学 | 50篇 |
基础医学 | 1283篇 |
口腔科学 | 223篇 |
临床医学 | 785篇 |
内科学 | 2277篇 |
皮肤病学 | 158篇 |
神经病学 | 557篇 |
特种医学 | 459篇 |
外国民族医学 | 1篇 |
外科学 | 1557篇 |
综合类 | 57篇 |
一般理论 | 1篇 |
预防医学 | 260篇 |
眼科学 | 400篇 |
药学 | 695篇 |
中国医学 | 30篇 |
肿瘤学 | 1108篇 |
出版年
2023年 | 56篇 |
2022年 | 122篇 |
2021年 | 200篇 |
2020年 | 116篇 |
2019年 | 144篇 |
2018年 | 207篇 |
2017年 | 160篇 |
2016年 | 191篇 |
2015年 | 201篇 |
2014年 | 276篇 |
2013年 | 306篇 |
2012年 | 454篇 |
2011年 | 498篇 |
2010年 | 265篇 |
2009年 | 252篇 |
2008年 | 469篇 |
2007年 | 489篇 |
2006年 | 489篇 |
2005年 | 440篇 |
2004年 | 494篇 |
2003年 | 455篇 |
2002年 | 453篇 |
2001年 | 311篇 |
2000年 | 287篇 |
1999年 | 262篇 |
1998年 | 129篇 |
1997年 | 96篇 |
1996年 | 80篇 |
1995年 | 74篇 |
1994年 | 89篇 |
1993年 | 65篇 |
1992年 | 182篇 |
1991年 | 170篇 |
1990年 | 179篇 |
1989年 | 168篇 |
1988年 | 162篇 |
1987年 | 119篇 |
1986年 | 110篇 |
1985年 | 147篇 |
1984年 | 97篇 |
1983年 | 72篇 |
1982年 | 41篇 |
1981年 | 39篇 |
1980年 | 44篇 |
1979年 | 68篇 |
1978年 | 51篇 |
1975年 | 37篇 |
1971年 | 37篇 |
1970年 | 40篇 |
1969年 | 42篇 |
排序方式: 共有10000条查询结果,搜索用时 24 毫秒
151.
H Makishima T Ito N Asano H Nakazawa S Shimodaira Y Kamijo Y Nakazawa T Suzuki H Kobayashi K Kiyosawa F Ishida 《Leukemia》2005,19(7):1169-1174
Natural killer (NK) cell-type lymphoproliferative diseases of granular lymphocytes can be subdivided into aggressive NK cell leukemia (ANKL) and chronic NK cell lymphocytosis (CNKL). One reason for the poor outcome in ANKL is leukemic infiltration into multiple organs. The mechanisms of cell trafficking associated with the chemokine system have been investigated in NK cells. To clarify the mechanism of systemic migration of leukemic NK cells, we enrolled nine ANKL and six CNKL cases, and analyzed the expression profiles and functions of chemokine receptors by flowcytometry and chemotaxis assay. CXCR1 was detected on NK cells in all groups, and CCR5 was positive in all ANKL cells. Proliferating NK cells were simultaneously positive for CXCR1 and CCR5 in all ANKL patients examined, and NK cells with this phenotype did not expand in CNKL patients or healthy donors. ANKL cells showed enhanced chemotaxis toward the ligands of these receptors. These results indicated that the chemokine system might play an important role in the pathophysiology of ANKL and that chemokine receptor profiling might be a novel tool for discriminating ANKL cells from benign NK cells. 相似文献
152.
Hitoshi Ishida Akira Nozawa Haruo Nukaya Lesley Rhodes Paul McNabb Patrick T Holland Kuniro Tsuji 《Toxicon》2004,43(6):701-712
We examined metabolism of PbTxs in New Zealand cockle, Austrovenus (A.) stutchburyi, and greenshell mussel, Perna (P.) canaliculus, by means of liquid chromatography coupled with tandem mass spectrometry. PbTx-2, PbTx-3 and BTX-B5 were detected in Karenia (K.) brevis culture medium in the ratio of ca. 50:2:5. The amounts of PbTx-3 and BTX-B5 were greatly increased in both seawater and shellfish exposed to K. brevis cultures or supernatant prepared by disruption of K. brevis under appropriate condition, while those of PbTx-2 were decreased. Some PbTx-2 was present in P. canaliculus, but not in A. stutchburyi. Low levels of BTX-B1 were detected in A. stutchburyi, but not P. canaliculus. Levels of PbTx-3 and BTX-B5 were highest immediately after exposure and then declined rapidly in both shellfish. BTX-B1 increased in concentration after exposure, and was then gradually eliminated from A. stutchburyi. Three successive exposures of A. stutchburyi to K. brevis cultures resulted in similar initial levels of PbTx-3 and BTX-B5, while BTX-B1 accumulated after each dose. In P. canaliculus, initial levels of PbTx-3 were similar, while PbTx-2 and BTX-B5 accumulated after each dose. PbTx-3 and BTX-B5 are proposed to be suitable markers for monitoring shellfish toxicity after a red tide event. 相似文献
153.
Tanaka T Ohkawa Y Toyama M Hashimoto M Ishida N Matsumoto K 《Kyobu geka. The Japanese journal of thoracic surgery》2000,53(9):763-765
From 1990 to 1999, 19 patients underwent aortic root replacement. Annulo-aortic ectasia was observed in 14 patients, aortic dissection in 4, and aortitis in 1. Mean aortic cross-clamp times and cardiopulmonary bypass times were 163 +/- 44 and 247 +/- 99 min, respectively. Concomitant procedures were coronary artery bypass grafting in 3 patients, aortic arch replacement in 1 and aortic arch replacement and elephant trunk method in 2. There were two hospital deaths due to cardiac failure. There was one late death because of pharyngeal cancer 1.7 years after the operation. Seventeen survivors were followed for a mean duration of 4.4 years (0.6-9.3 years). There were no complications during this period. In conclusion, good results were obtained by modified Bentall operation. 相似文献
154.
155.
156.
Novel PSTPIP1 gene mutation in pyoderma gangrenosum,acne and suppurative hidradenitis syndrome
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
157.
Kyoko Kanno Masako Minami‐Hori Akemi Ishida‐Yamamoto Keiji Komura Kensuke Oikawa Naoyuki Miyokawa Hajime Iizuka 《The Journal of dermatology》2014,41(8):736-738
We report a 38‐year‐old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high‐grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68‐positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease. 相似文献
158.
Shigetsuna Komatsu Masaru Honma Satomi Igawa Hitomi Tsuji Akemi Ishida‐Yamamoto Kiyoshi Migita Hiroaki Ida Hajime Iizuka 《The Journal of dermatology》2014,41(9):827-829
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease, which is characterized by recurrent and paroxysmal fever, peritonitis, arthritis, myalgia, and skin rashes. Although various skin lesions such as “erysipelas‐like erythema”, urticaria, nonspecific purpura, and subcutaneous nodules have been described, cutaneous vasculitis is rare. We report a Japanese case of sporadic FMF accompanied by cutaneous arteritis at the time of febrile attacks of FMF. Gene analysis revealed M694I mutation in a single allele of the MEFV gene, and oral colchicine successfully controlled both periodic fever and subcutaneous nodules of arteritis. Cutaneous necrotizing vasculitis repeatedly emerging with febrile attacks should be included among the skin manifestations of FMF. 相似文献
159.
Comparison of micafungin and voriconazole as empirical antifungal therapies in febrile neutropenic patients with hematological disorders: a randomized controlled trial
下载免费PDF全文
![点击此处可从《European journal of haematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
160.
Yui Ito Mitsuaki Ishida Chisato Ohe Chika Miyasaka Koji Tsuta 《Journal of cutaneous pathology》2021,48(1):102-105
Signet‐ring cell/histiocytoid carcinoma (SRCHC) is a very rare skin appendage cancer, with an extremely rare occurrence in the axilla. This study describes the 11th case of SRCHC occurring in the axilla and reports the first gene alteration analysis performed for SRCHC. An 85‐year‐old Japanese male presented with a tumor in the left axilla. Biopsy of the axilla nodule demonstrated diffuse proliferation of histiocytoid neoplastic cells and signet‐ring cells in the dermis and subcutis. Immunohistochemistry revealed loss of E‐cadherin expression in these neoplastic cells. Accordingly, SRCHC of the axilla was diagnosed. Genetic analysis using next‐generation sequencing demonstrated missense mutation of PIK3CA (c1633G>A, pGlu545Lys) and no CDH1 gene mutation.SRCHC of the axilla is considered equivalent to a histiocytoid variant of invasive lobular breast carcinoma. The present SRCHC case demonstrated a pathogenic PIK3CA mutation, which is observed in invasive lobular carcinoma. Additional large case studies are required to clarify the clinicopathological features and gene alterations in SRCHC of the axilla. 相似文献