The association between trans fatty acids,infertility and fetal life: a review

Trans fatty acids (TFAs) are thought to affect reproductive health by causing adverse effects on sperm morphology and ovum quality as a result of changing membrane lipid composition which, in turn, leads to impairment in metabolic pathways. This literature review examines the evidence for the effects of dietary TFAs on male and female infertility. Studies conducted between 2007 and 2017 on the effect of dietary TFAs on human reproductive health and fetal life have been included. They indicate that TFA intakes are inversely proportional to sperm concentration and total sperm count and exhibit a positive correlation with asthenospermia, as well as an adverse association on sperm concentration and semen quality. In the female TFAs intakes are associated with an increase in the risk of ovulatory infertility, adversely affect the length of gestation leading to fetal developmental defects and fetal loss. The findings suggest that high TFA intake (more than 1% of energy consumption) constitute a risk factor for infertility in both sexes.     

Immediate and Follow‐Up Results of Repeat Percutaneous Mitral Balloon Commissurotomy for Restenosis After a Succesful First Procedure

Background: The widespread use of percutaneous mitral commissurotomy (PMC) has led to an increase in restenosis cases. The data regarding follow‐up results of repeat PMC are quite limited. The aim of this retrospective analysis is to evaluate the immediate and midterm results of the second PMC, in patients with symptomatic mitral restenosis after a succesful first procedure. Methods: Twenty patients (95% female, mean age 37 ± 4 years) who have undergone a second PMC, 6.3 ± 2.5 years after a first successful intervention built the study group. All were in sinus rhythm, with a mean Wilkins score of 8.5 ± 1.2. Results: The valve area increased from 1.2 ± 0.2 to 1.9 ± 0.2 cm² and mean gradient decreased from 10.5 ± 3.4 to 6.1 ± 1.1 mmHg. There were no complications except for a transient embolic event without sequela (5%) and two cases (10%) of severe mitral regurgitation. The immediate success rate was 90%. The mean follow‐up was 70 ± 29 months (36–156 months). The 5‐year restenosis and intervention (repeat PMC or valve replacement) rates were 9.1 ± 5.2% and 3.6 ± 3.3%, respectively. The intervention free 5‐year survival in good functional capacity (New York Heart Association [NYHA] I–II) was 95.1 ± 5.5% and restenosis and intervention free 5‐year survival with good functional capacity was 89.7 ± 6.8%. Conclusions: Although from a limited number of selected patients, these findings indicate that repeat PMC is a safe and effective method, with follow‐up results similar to a first intervention and should be considered as the first therapeutic option in suitable patients. (Echocardiography 2010;27:765‐769)     

正交试验优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量条件

摘 要 目的： 优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量试验条件,并对蒙药“那仁满都拉”水溶性糖进行含量测定。方法: 在单因素试验基础上,对影响水溶性糖含量测定的四个因素：反应温度、反应时间、硫酸浓度,蒽酮浓度进行正交试验设计,优选最佳测定条件。结果: 蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量的最佳条件为：反应温度80℃、反应时间45 min、硫酸浓度75%、蒽酮浓度0.2%。在此条件下,葡萄糖在2.040 0～32.580 0 mg·mL^-1范围内线性关系良好,r=0.999 6,平均回收率为101.88%,RSD为0.69%。三批样品含量测定的RSD均小于0.95%。结论: 用蒽酮 硫酸法测定“那仁满都拉”中的水溶性糖含量时,显色条件对定量有不容忽视的影响。