全文获取类型
收费全文 | 7056篇 |
免费 | 657篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 283篇 |
妇产科学 | 185篇 |
基础医学 | 812篇 |
口腔科学 | 200篇 |
临床医学 | 761篇 |
内科学 | 1389篇 |
皮肤病学 | 75篇 |
神经病学 | 693篇 |
特种医学 | 255篇 |
外科学 | 807篇 |
综合类 | 202篇 |
一般理论 | 5篇 |
预防医学 | 859篇 |
眼科学 | 68篇 |
药学 | 588篇 |
中国医学 | 4篇 |
肿瘤学 | 465篇 |
出版年
2022年 | 41篇 |
2021年 | 106篇 |
2020年 | 72篇 |
2019年 | 124篇 |
2018年 | 112篇 |
2017年 | 110篇 |
2016年 | 115篇 |
2015年 | 125篇 |
2014年 | 161篇 |
2013年 | 233篇 |
2012年 | 363篇 |
2011年 | 384篇 |
2010年 | 193篇 |
2009年 | 206篇 |
2008年 | 308篇 |
2007年 | 320篇 |
2006年 | 290篇 |
2005年 | 284篇 |
2004年 | 335篇 |
2003年 | 275篇 |
2002年 | 252篇 |
2001年 | 227篇 |
2000年 | 225篇 |
1999年 | 191篇 |
1998年 | 93篇 |
1997年 | 86篇 |
1996年 | 98篇 |
1995年 | 74篇 |
1994年 | 81篇 |
1993年 | 66篇 |
1992年 | 145篇 |
1991年 | 123篇 |
1990年 | 182篇 |
1989年 | 139篇 |
1988年 | 105篇 |
1987年 | 137篇 |
1986年 | 120篇 |
1985年 | 136篇 |
1984年 | 113篇 |
1983年 | 102篇 |
1982年 | 46篇 |
1981年 | 59篇 |
1979年 | 79篇 |
1978年 | 45篇 |
1977年 | 56篇 |
1976年 | 57篇 |
1974年 | 62篇 |
1973年 | 42篇 |
1972年 | 51篇 |
1969年 | 39篇 |
排序方式: 共有7738条查询结果,搜索用时 31 毫秒
91.
It is frequently observed in contemporary industrialised societies that although women live longer than men, they are sicker than men in that they report higher rates of morbidity, disability and health care use. One common element of the explanation for women's higher rates of morbidity is that there are gender differences in the way that symptoms are perceived, evaluated and acted upon. It is widely assumed that women will be more ready to report illness and to seek help and that they have greater flexibility in their lives to accommodate illness. The few studies that have examined men and women with the same conditions or symptoms are contradictory, but lend little support to this hypothesised greater propensity, yet it is still widely believed. Here we compare men's and women's answers to a global, commonly used question about chronic illness and to a series of more specific prompts and classify the conditions reported by an externally defined categorisation of severity and International Classification of Disease chapter. Contrary to the common expectation that women report higher rates of morbidity and are more ready to report mental health problems, we found: no gender differences in the initial reporting of conditions; men reported a higher proportion of their conditions in response to the initial global question; and no evidence that women were more likely to report 'trivial' or mental health conditions in response to the initial question. 相似文献
92.
E S Ford 《International journal of epidemiology》1999,28(4):645-651
BACKGROUND: Animal and human data suggest that magnesium may play an important role in ischaemic heart disease. Few prospective epidemiological studies have related serum magnesium concentrations to mortality from ischaemic heart disease (IHD) or all-causes. METHODS: Data from the National Health and Nutrition Examination Survey Epidemiologic Followup Study were used to examine the association between serum magnesium concentration, measured between 1971-1975, and mortality from IHD or all-causes in a national sample of 25-74-year-old participants followed for about 19 years. RESULTS: The analytical samples for IHD and all-cause-mortality included 12 340 and 12 952 participants, respectively (1005 IHD deaths, 2637 IHD deaths or hospitalizations, 4282 total deaths). Hazard ratios for IHD mortality from proportional hazards analysis comparing the second (1.59-<1.68 mEq/l), third (1.68-<1.77 mEq/l), and fourth (> or =1.77 mEq/1) quartiles of serum magnesium concentration with the lowest quartile were 0.79 (95% CI: 0.58-1.08), 0.66 (95% CI: 0.47-0.93), 0.69 (95% CI: 0.52-0.90), respectively. For all-cause mortality, hazards ratios were 0.82 (95% CI: 0.72-0.93), 0.84 (95% CI: 0.73-0.96), 0.85 (95% CI: 0.75-0.95). No significant interactions between serum magnesium concentration and age, sex, race, and education were observed. CONCLUSION: Serum magnesium concentrations were inversely associated with mortality from IHD and all-cause mortality. 相似文献
93.
Ford R 《The Health service journal》1999,109(5679):26-27
The publication of the national service framework for mental health provides a good opportunity to review acute psychiatric services, which are unpopular with patients and understaffed. The framework recommends a balance of hospital beds, community provision and home care. Planning should usually cover one or more primary care groups. 相似文献
94.
Ford WR Maddock HL Buckingham RE Broadley KJ 《The Journal of pharmacy and pharmacology》1999,51(10):1183-1190
The relaxant effect of adenosine and 5'-(N-ethylcarboxamido)adenosine (NECA) against alpha-adrenoceptor-mediated contractile tone in guinea-pig isolated aortic rings has been examined to determine if this A2B-receptor-mediated relaxation was dependent upon the contracting agent, and whether the contractions were dependent upon intracellular or extracellular calcium. Relaxation responses were consistently greater for aortic rings pre-contracted with phenylephrine (3x10(-6) M) than for rings pre-contracted with noradrenaline (3x10(-6) M). Maximum inhibition by NECA was significantly greater for phenylephrine-contracted aortae than for noradrenaline-contracted (81.9+/-2.8% compared with 25.0+/-1.5%). These differences persisted in the presence of beta- and alpha2-adrenoceptor blockade and could not, therefore, be attributed to stimulation of these receptors by noradrenaline. The ratio of the contractions obtained before and in the presence of adenosine or NECA was compared with the control ratio obtained before and after vehicle. Experiments were performed both in the presence of normal calcium levels and under calcium-free conditions. In normal-calcium medium, NECA inhibited phenylephrine-induced contractions (test ratio, 76.7+/-3.9%; control ratio, 133.1+/-9.8%) to a greater extent than noradrenaline-induced contractions (108.4+/-4.1 and 123.4+/-4.9%); adenosine similarly inhibited phenylephrine-induced contractions more than those induced by noradrenaline. Under calcium-free conditions, adenosine (36.7+/-11.9 and 110.7+/-26.6%) and NECA (55.2+/-9.1 and 87.1+/-14.9%) were only effective against phenylephrine-induced contractions. This suggests that activation of the A2B-receptor by these agonists inhibited intracellular mobilization of calcium for phenylephrine-induced contractions only. The effects on extracellular calcium influx were examined for phenylephrine- and noradrenaline-induced contractions in normal-calcium medium but in the presence of ryanodine to prevent intracellular calcium mobilization. NECA inhibited phenylephrine-induced contractions (77.3+/-12.4 and 111.4+/-9.3%), presumably by interfering with influx of calcium through receptor-operated calcium channels. In contrast, NECA failed to reduce noradrenaline-induced contractions (121.5+/-10.7 and 122.4+/-11.6%), suggesting that the effect on noradrenaline is predominantly via interaction with intracellular calcium. Adenosine was consistently a more effective relaxant than NECA, possibly because of an additional intracellular component of the response. We conclude that adenosine receptor agonists inhibit phenylephrine-induced contractions of guinea-pig aorta more selectively than noradrenaline-induced contractions. A2B-receptor stimulation might reveal a fundamental difference between the modes of contraction elicited by these two alpha-adrenoceptor agonists. 相似文献
95.
Dargie H. J.; Ford I.; Fox K. M.; on behalf of the TIBET study group 《European heart journal》1996,17(1):104-112
OBJECTIVES: To study the relationship between presence or absence of ischaemicevents on Holter monitoring and occurrence of a hard or hard+softendpoint. DESIGN: A randomized double-blind parallel group study of atenolol,nifedipine and their combination, with ambulatory monitoringoff-treatment and after 6 weeks of randomized treatment andprospective follow-up of 2 years on average. SETTING: Europe. SUBJECTS: 682 men and women with a diagnosis of chronic stable anginaand who were not being considered for surgery. MAIN OUTCOME: Hard endpoints were cardiac death, nonfatal myocardial infarctionand unstable angina; soft endpoints were coronary artery bypasssurgery, coronary angioplasty and treatment failure. RESULTS: The study showed no evidence of an association between the presence,frequency or total duration of ischaemic events on Holter monitoring,either on or off treatment, and the main outcome measures. Therewas a non-significant trend to a lower rate of hard endpointsin the group receiving combination therapy. Compliance, as measuredby withdrawal from trial medication, was clearly poorest inthe nifedipine group with similar with drawal rates in the atenololand combination therapy groups. CONCLUSION: The recording of ischaemic events in 48 h Holter monitoringfailed to predict hard or hard+soft endpoints in patients withchronic stable angina. 相似文献
96.
97.
Stephen M. Koch David C. Abramson Michael Ford David Peterson Jeffrey Katz 《Journal canadien d'anesthésie》1996,43(1):73-76
Purpose
To present the first photographed bronchoscopic findings associated with negative pressure pulmonary oedema (NPPE).Clinical features
A previously healthy patient underwent anterior C3–C4 disc removal and arthrodesis. Following tracheal extubation he developed acute respiratory distress manifested as stridor, tachypnoea, restlessness, and desaturation. Once the trachea was reintubated, he displayed the classic findings of pulmonary oedema. Bronchoscopy was performed to confirm tracheal tube position and to rule out tracheal injury secondary to surgical manipulation. Diffuse punctate haemorrhages were noted throughout the visualised tracheobronchial tree.Conclusion
We believe that these haemorrhages represent disruption of the bronchial vasculature and may contribute to the clinical presentation of NPPE. 相似文献98.
One hundred patients undergoing abdominal surgery were included in this prospective study. The role of local application of Betadine, use of synthetic sutures, and use of low pressure subcutaneous suction drainage were evaluated in preventing post-operative wound infection. The infection rate was 15 per cent with Betadine, 15.4 per cent with prolene, 20 per cent with subcutaneous suction drainage and 30.8 per cent in the control group.KEY WORDS: Surgical wound infection, Betadine, Sutures, Infection control 相似文献
99.
100.
Summary The cortical imaging technique (CIT), a mathematical method for simulating the potential fields on the surface of the brain, was used to analyze the spatio-temporal progression of the AEP P300 component (as well as the preceding and subsequent N2a and N3 components) from thirty normal adult subjects recorded in a standard oddball paradigm. Comparisons were made between the progressions of the endogenous event-related cognitive potentials and the exogenous stimulus-dependent potentials (Nl component). Cortical imaging results suggest that different and multiple generator sites are involved in the production of exogenous and endogenous evoked responses. We particularly note the asymmetric development of the P300 component and the apparent anterior generator sites for the N2a component. This last result is interesting because the N2a precedes the P300 component and supports an earlier frontal contribution. 相似文献