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51.
Jennie E. Murray Louise S. Bicknell Gökhan Yigit Angela L. Duker Margriet van Kogelenberg Sara Haghayegh Dagmar Wieczorek Hülya Kayserili Michael H. Albert Carol A. Wise January Brandon Tjitske Kleefstra Adilia Warris Michiel van der Flier J. Steven Bamforth Kurston Doonanco Lesley Adès Alan Ma Michael Field Diana Johnson Fiona Shackley Helen Firth C. Geoffrey Woods Peter Nürnberg Richard A. Gatti Matthew Hurles Michael B. Bober Bernd Wollnik Andrew P. Jackson 《Human mutation》2014,35(1):76-85
Ligase IV syndrome is a rare differential diagnosis for Nijmegen breakage syndrome owing to a shared predisposition to lympho‐reticular malignancies, significant microcephaly, and radiation hypersensitivity. Only 16 cases with mutations in LIG4 have been described to date with phenotypes varying from malignancy in developmentally normal individuals, to severe combined immunodeficiency and early mortality. Here, we report the identification of biallelic truncating LIG4 mutations in 11 patients with microcephalic primordial dwarfism presenting with restricted prenatal growth and extreme postnatal global growth failure (average OFC ?10.1 s.d., height ?5.1 s.d.). Subsequently, most patients developed thrombocytopenia and leucopenia later in childhood and many were found to have previously unrecognized immunodeficiency following molecular diagnosis. None have yet developed malignancy, though all patients tested had cellular radiosensitivity. A genotype–phenotype correlation was also noted with position of truncating mutations corresponding to disease severity. This work extends the phenotypic spectrum associated with LIG4 mutations, establishing that extreme growth retardation with microcephaly is a common presentation of bilallelic truncating mutations. Such growth failure is therefore sufficient to consider a diagnosis of LIG4 deficiency and early recognition of such cases is important as bone marrow failure, immunodeficiency, and sometimes malignancy are long term sequelae of this disorder. 相似文献
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Evaluation of atypical human immunodeficiency virus immunoblot reactivity in blood donors 总被引:6,自引:0,他引:6
NL Dock ; HV Lamberson Jr ; TA O''Brien ; DE Tribe ; SS Alexander ; BJ Poiesz 《Transfusion》1988,28(5):412-418
Blood donors reactive by enzyme-linked immunosorbent assay for antibody to the human immunodeficiency virus (HIV) who showed atypical patterns of viral core protein reactivity on Western blot were monitored for several months. Characterization of their antibodies was performed by 1) use of recombinant HIV proteins; 2) determination of cross-reactivity to HTLV-I, HTLV-II, and HTLV-IV: 3) assessment of immune status; and 4) identification of potentially interfering autoantibodies. Nineteen of 20 donors maintained the same HIV antibody reactivity throughout the follow-up period; the other donor became fully antibody-positive. Eighteen of 20 donors' sera showed clear reactivity with HIV recombinant core proteins. Ten of 19 donor samples demonstrated cross-reactivity to HTLV-IV; 3 of these 10 also cross-reacted with HTLV-I. The immune status of all donors was normal, although the medical histories and HLA antibody screens suggested possible autoimmune reactivity in 9 of 18 donors. During follow-up interviews, three donors reported possible risk factors for HIV infection that had not been acknowledged at the time of blood donation. We conclude that exclusion of donors with these atypical serologic test results is warranted while further studies to determine significance are being conducted. 相似文献
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Poulsen RC Firth EC Rogers CW Moughan PJ Kruger MC 《Calcified tissue international》2007,81(6):459-471
Long chain polyunsaturated fatty acids (LCPUFAs) are involved in the regulation of bone metabolism. Increased dietary consumption
of n-3, and possibly some n-6, LCPUFAs may limit postmenopausal bone loss. The aim of this study was to determine the effects
on bone of specific fatty acids within the n-3 and n-6 LCPUFA families in ovariectomized (OVX) rats. Rats were OVX or sham-operated
and fed either a control diet (OVX and sham) or a diet supplemented with 0.5 g/kg body weight/day of γ-linolenic (GLA), eicosapentaenoic
(EPA), docosahexaenoic (DHA) ethyl esters or a mixture of all three (MIX) for 16 weeks. Bone mineral content (BMC), area,
and density and plasma concentrations of insulin-like growth factor-I, vitamin D, selected biochemical markers of bone metabolism,
and parathyroid hormone (PTH) were determined. The OVX-induced decrease in lumbar spine BMC was significantly attenuated by
DHA but not by EPA or GLA supplementation or supplementation with a mixture of all three LCPUFAs. Endosteal circumferences
of tibiae were significantly greater in DHA and EPA compared to OVX. Plasma C-terminal telopeptide of type I collagen and
osteocalcin concentrations were not significantly different in the DHA group compared to OVX. Femur BMC decreased by a significantly
greater amount in GLA than OVX, and final plasma PTH concentrations were significantly higher in GLA compared to all other
groups. In conclusion, DHA ameliorated OVX-induced bone mineral loss. GLA exacerbated post-OVX bone mineral loss, possibly
as a result of PTH-induced bone catabolism. 相似文献
56.
Hugh Firth 《British Journal of Learning Disabilities》1983,11(2):61-64
A home visiting service for parents whose mentally handicapped children were exhibiting difficult behaviour at home is described, with details of providing the service to 33 families with children aged from 3 to 15 years. The most frequent problems were socially unacceptable behaviour and incontinence, but self-help, communication, and play skills were also tackled. Visits were usually made every 3 to 4 weeks for periods from 3 to 27 months. Targets were achieved or some progress was gained in over two-thirds of the problems tackled. An average of eight hours was spent with each family. Home visiting proved as efficient as parent groups when measured by targets achieved as a function of parent and therapist time. 相似文献
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