全文获取类型
收费全文 | 92篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
基础医学 | 7篇 |
口腔科学 | 1篇 |
临床医学 | 6篇 |
内科学 | 48篇 |
皮肤病学 | 1篇 |
神经病学 | 3篇 |
外科学 | 12篇 |
综合类 | 1篇 |
预防医学 | 4篇 |
眼科学 | 2篇 |
药学 | 1篇 |
出版年
2022年 | 2篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 6篇 |
2012年 | 5篇 |
2011年 | 3篇 |
2010年 | 5篇 |
2009年 | 9篇 |
2008年 | 7篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有99条查询结果,搜索用时 15 毫秒
91.
92.
93.
Nationwide Experience With Off‐Label Use of Interleukin‐1 Targeting Treatment in Familial Mediterranean Fever Patients 下载免费PDF全文
Servet Akar Pınar Cetin Umut Kalyoncu Omer Karadag Ismail Sari Muhammed Cınar Sedat Yilmaz Ahmet Mesut Onat Bunyamin Kisacik Abdulsamet Erden Ayse Balkarli Orhan Kucuksahin Sibel Yilmaz Oner Soner Senel Abdurrahman Tufan Haner Direskeneli Ferhat Oksuz Yavuz Pehlivan Ozun Bayindir Gokhan Keser Kenan Aksu Ahmet Omma Timucin Kasifoglu Ali Ugur Unal Fatih Yildiz Mehmet Ali Balci Sule Yavuz Sukran Erten Metin Ozgen Mehmet Sayarlıoglu Atalay Dogru Gozde Yildirim Fatma Alibaz Oner Mehmet Engin Tezcan Omer Nuri Pamuk Fatos Onen 《Arthritis care & research》2018,70(7):1090-1094
Objective
Approximately 30–45% of patients with familial Mediterranean fever (FMF) have been reported to have attacks despite colchicine treatment. Currently, data on the treatment of colchicine‐unresponsive or colchicine‐intolerant FMF patients are limited; the most promising alternatives seem to be anti–interleukin‐1 (anti–IL‐1) agents. Here we report our experience with the off‐label use of anti–IL‐1 agents in a large group of FMF patients.Methods
In all, 21 centers from different geographical regions of Turkey were included in the current study. The medical records of all FMF patients who had used anti–IL‐1 treatment for at least 6 months were reviewed.Results
In total, 172 FMF patients (83 [48%] female, mean age 36.2 years [range 18–68]) were included in the analysis; mean age at symptom onset was 12.6 years (range 1–48), and the mean colchicine dose was 1.7 mg/day (range 0.5–4.0). Of these patients, 151 were treated with anakinra and 21 with canakinumab. Anti–IL‐1 treatment was used because of colchicine‐resistant disease in 84% and amyloidosis in 12% of subjects. During the mean 19.6 months of treatment (range 6–98), the yearly attack frequency was significantly reduced (from 16.8 to 2.4; P < 0.001), and 42.1% of colchicine‐resistant FMF patients were attack free. Serum levels of C‐reactive protein, erythrocyte sedimentation rate, and 24‐hour urinary protein excretion (5,458.7 mg/24 hours before and 3,557.3 mg/24 hours after) were significantly reduced.Conclusion
Anti–IL‐1 treatment is an effective alternative for controlling attacks and decreasing proteinuria in colchicine‐resistant FMF patients.94.
Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study 总被引:19,自引:0,他引:19
Tunca M Akar S Onen F Ozdogan H Kasapcopur O Yalcinkaya F Tutar E Ozen S Topaloglu R Yilmaz E Arici M Bakkaloglu A Besbas N Akpolat T Dinc A Erken E;Turkish FMF Study Group 《Medicine》2005,84(1):1-11
Familial Mediterranean fever (FMF) is an autosomal recessive disease that is prevalent among eastern Mediterranean populations, mainly non-Ashkenazi Jews, Armenians, Turks, and Arabs. Since a large proportion of all the FMF patients in the world live in Turkey, the Turkish FMF Study Group (FMF-TR) was founded to develop a patient registry database and analyze demographic, clinical, and genetic features. The cohort was composed of 2838 patients (mean age, 23.0 +/- 13.33 yr; range, 2-87 yr), with a male:female ratio of 1.2:1. There was a mean period of 6.9 +/- 7.65 years from disease onset to diagnosis; the period was about 2 years shorter for each decade since 1981. Ninety-four percent of patients were living in the central-western parts of the country; however, their familial origins (70% from the central-eastern and Black Sea regions) reflected not only the ongoing east to west migration, but also the historical roots of FMF in Turkey. Patients' clinical features included peritonitis (93.7%), fever (92.5%), arthritis (47.4%), pleuritis (31.2%), myalgia (39.6%), and erysipelas-like erythema (20.9%). Arthritis, arthralgia, myalgia, and erysipelas-like erythema were significantly more frequent (p < 0.001) among patients with disease onset before the age of 18 years. Genetic analysis of 1090 patients revealed that M694V was the most frequent mutation (51.4%), followed by M680I (14.4%) and V726A (8.6%). Patients with the M694V/M694V genotype were found to have an earlier age of onset and higher frequencies of arthritis and arthralgia compared with the other groups (both p < 0.001). In contrast to other reported studies, there was no correlation between amyloidosis and M694V homozygosity in this cohort. However, amyloidosis was still remarkably frequent in our patients (12.9%), and it was prevalent (27.8%) even among the 18 patients with a disease onset after age 40 years. Twenty-two patients (0.8%) had nonamyloid glomerular diseases. The high prevalence of vasculitides (0.9% for polyarteritis nodosa and 2.7% for Henoch-Schonlein purpura) and high frequency of pericarditis (1.4%) were striking findings in the cohort. Phenotype II cases (those patients with amyloidosis as the presenting or only manifestation of disease) were rare (0.3% or less). There was a high rate of a past diagnosis of acute rheumatic fever, which suggested a possible misdiagnosis in children with FMF presenting with recurrent arthritis. To our knowledge, this is the largest series of patients with FMF reported from 1 country. We describe the features of the disease in the Turkish population and show that amyloidosis is still a substantial problem. 相似文献
95.
Suat Fitoz Mesiha Ekim Zeynep Birsin Ozcakar Atilla Halil Elhan Fatos Yalcinkaya 《Journal of ultrasound in medicine》2007,26(5):573-580
OBJECTIVE: The purpose of this study was to evaluate the pathophysiologic characteristics of nutcracker syndrome (NS) and to assess the role of upright position imaging and superior mesenteric artery (SMA) angle measurement in the diagnosis. METHODS: Doppler sonographic findings in 23 children with NS and in 26 healthy control subjects were compared. The mesenteric angle, peak velocity (PV), and anteroposterior diameter of the left renal vein (LRV) at the hilar and aortomesenteric portions were measured in both the supine and upright positions. The means +/- SD of the SMA angle, anteroposterior diameter, and PV ratio between the two portions were calculated, and cutoff levels for the diagnosis of NS were established. RESULTS: The diameter and PV ratios were significantly different between the patient and control groups in both the supine and upright positions (P < .001). Differences between the supine and upright positions were also significant for the diameter of the LRV at the aortomesenteric portion, diameter ratio, and SMA angle in both groups. Upright position imaging revealed comparatively narrower SMA angles and more pronounced entrapment findings in patients with NS. The SMA angle measurement had sensitivity and specificity of 69.6% and 61.5%, respectively, in the supine position and 87.0% and 76.9% in the upright position when the cutoff values were set to less than 41 degrees and 21 degrees , respectively. CONCLUSIONS: The upright position has significant effects on the LRV hemodynamics and angle of the SMA in both patients and healthy subjects. Superior mesenteric artery angle measurement may be a useful adjunct parameter in the diagnosis of NS. 相似文献
96.
Servet Akar Mehmet Ali Ozcan Halil Ate? O?uz Gürler Inci Alacacioglu G Hayri Ozsan Nurullah Akko? Sebnem Ozkan Fatih Demirkan Fatos Onen 《Clinical and applied thrombosis/hemostasis》2006,12(4):451-457
Beh?et's disease (BD) is a multisystem disorder. Venous as well as arterial thrombosis is a common complication of BD but exact pathogenetic mechanism of the thrombotic tendency is not well known. This study aimed to evaluate circulating activated platelets and platelet reactivity in Beh?et's patients. Twenty-two Beh?et's patients (4 female, 18 male; mean age 38.6 +/- 10.9 years) and 20 control subjects (8 female, 12 male; mean age 38.8 +/- 9.4 years) were included. Those patients who had hypertension, hyperlipidemia, peripheral or coronary artery disease, hepatic or renal function abnormality, and who were using aspirin and other platelet-active drugs were excluded. Platelet activity and reactivity to adenosine diphosphate (ADP) were measured by whole blood flow cytometry. We assessed markers of platelet degranulation (P-selectin; CD62P) and the activated glycoprotein IIb/IIIa receptor (PAC1 binding to fibrinogen binding site) before and after stimulation with ADP. Platelet P-selectin expression was not significantly different between patients and control subjects both at baseline (p=0.420) and after stimulation (p=0.56). Baseline (p=0.001) and ADP-stimulated (p=0.003) PAC1 binding was significantly higher in Beh?et's patients than in the control group. Clinical activity has no effect on P-selectin expression and PAC1 binding. There is evidence of platelet activity and hyperreactivity in patients with BD and this may contribute to a prothrombotic state. In addition to aspirin, other antiplatelet drugs may be useful in the prevention and treatment of thrombosis in Beh?et's patients. 相似文献
97.
Gercek Can Dilek Solmaz Omer Binicier Servet Akar Merih Birlik Ozgul Soysal Nurullah Akkoc Metin Manisali Fatos Onen 《Rheumatology international》2013,33(5):1289-1293
The aim of this study was to investigate the frequency of patients with rheumatoid arthritis (RA) who have inflammatory back pain (IBP) and meet the existing classification criteria for ankylosing spondylitis (AS) and spondyloarthritis (SpA). We included 167 patients fulfilling the ACR 1987 revised criteria for RA. After obtaining a medical history and performing a physical examination, standard pelvic X-rays for examination of the sacroiliac joints (SIJ) were ordered in all patients. A computed tomography (CT) or magnetic resonance imaging (MRI) of SIJ was performed in patients with suspected radiographic sacroiliitis and MRI of SIJ in those who have IBP but no radiographic sacroiliitis. IBP was defined according to both Calin and experts’ criteria. The modified New York (mNY) criteria were used to classify AS, both ESSG and Amor criteria for SpA and ASAS classification criteria for axial SpA. There were 135 female and 32 male patients with a mean age of 54.8 years. The mean disease duration was 9.8 years. RF was positive in 128 patients (79.2 %) and anti-CCP in 120 patients (81.1 %). Twenty-eight patients with RA (16.8 %) had IBP (Calin criteria), and four (2.4 %) had radiographic sacroiliitis of bilateral grade 3. Three patients (1.8 %) fulfilled the mNY criteria for AS, 31 (18.6 %) ESSG and 26 (15.6 %) Amor criteria for SpA. Nine patients (five with MRI sacroiliitis) (5.3 %) were classified as having axial SpA according to new ASAS classification criteria. This study suggests that the prevalence of SpA features in patients with RA may be much higher than expected. 相似文献
98.
Ismail Sari Servet Akar Betul Pakoz Ali Riza Sisman Oguz Gurler Merih Birlik Fatos Onen Nurullah Akkoc 《Rheumatology international》2009,29(8):869-874
The aim of this study was to examine the prevalence of hyperuricemia and its associated factors in an urban area of Izmir,
located in western Turkey. Our study group was selected by computerized sampling from the participants of a larger population-based
study searching for the prevalence of rheumatoid arthritis in Balcova and Narlidere districts of Izmir. A total of 132 subjects
(69 women and 63 men) were included in this study. Serum uric acid, glucose, creatinine and lipid levels were studied. Body
composition along with body fat percentage was determined anthropometrically. A total of 16 subjects had hyperuricemia (4
women and 12 men). The overall prevalence of hyperuricemia was 12.1% and the mean uric acid level was 4.9 ± 1.3 mg/dl. Males
had significantly higher uric acid levels than females (P < 0.05; 5.5 ± 1.3 vs. 4.3 ± 1.1 mg/dl, respectively). The prevalence of hypertension, diabetes, obesity and metabolic syndrome
was 24.4, 5.3, 28 and 26.5%, respectively. There was no gouty subject. Sum of skinfold thickness (SFT) measurements and creatinine
levels were the independent predictors of hyperuricemia (β = 0.45, 0.47, respectively). Uric acid measurement is important
not only for inflammatory rheumatic disorders but also for predicting metabolic syndrome and related coronary artery disease.
There is sex difference in uric acid levels in favor of women most probably explained by gonadal hormones. Hyperuricemia is
significantly predicted by anthropometric measure of SFT which is a simple clinical screening method along with creatinine
levels. 相似文献
99.
Kivanc Akad Dilek Solmaz Ismail Sari Fatos Onen Nurullah Akkoc Servet Akar 《Rheumatology international》2013,33(10):2617-2623
The aim of this study was to compare the performance characteristics of two answer modalities for BASDAI and BASFI in patients with AS and to show validity and reliability of NRS in Turkish version. BASDAI and BASFI were simultaneously employed with a 10-cm VAS and an 11-point NRS. Internal consistency was assessed by using Cronbach’s alpha coefficients. Testing was performed on baseline and next day under standardized conditions. Construct validity was determined by association of these measures with ASDAS, DFI, global disease activity, pain scores, ASQOL, HAQ, and SF-36. We also tested the ability of NRS version of BASDAI and BASFI to detect changes. A total 114 patients with AS according to the modified New York criteria were included. There was a good agreement between the total scores of each instrument on day 0 (ICC values were 0.894–0.934). Scores of the both answering modality of each instrument were correlated with ASDAS-CRP, and the scores of DFI, patient global assessment of disease activity and patient-reported pain, ASQOL, HAQ. Response time for BASDAI and BASFI was significantly shorter in NRS answer modality (P < 0.001). Our patients found NRS modality more comprehensible and easier to understand (P < 0.001). Our results showed the validity of NRS version of BASDAI and BASFI and provided an evidence for using these questionnaires in 11-point NRS answer modality in Turkish AS patients. 相似文献