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71.
M Sala J Perez P Soloff S Ucelli di Nemi E Caverzasi J C Soares P Brambilla 《European neuropsychopharmacology》2004,14(5):393-405
The hippocampus plays a main role in regulating stress response in humans, but is itself highly sensitive to neurotoxic effects of repeated stressful episodes. Hippocampal atrophy related to experimental stress has been reported in laboratory studies in animals. Several controlled brain imaging studies have also shown hippocampal abnormalities in psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and borderline personality disorder (BPD). This paper reviews the physiological role of the hippocampus in stress circuitry and the effects of stress on cognitive functions mediated by the hippocampus. We also review brain imaging studies investigating hippocampus in PTSD, MDD, and BPD. This literature suggests that individuals with PTSD, MDD, and BPD may suffer hippocampal atrophy as a result of stressors associated with these disorders. Prospective, longitudinal studies will be needed in high-risk offspring and first-episode subjects to explore the relationship between stress and hippocampal atrophy in these neuropsychiatric illnesses. 相似文献
72.
Hellen Silva Cintra Juliana Castro Dourado Pinezi Graziella Dias Pinheiro Machado Gustavo Moura de Carvalho Ana Terra Silva Carvalho Thalles Eduardo Dias dos Santos Ricardo Duarte Marciano Renata de Bastos Ascen?o Soares 《Disease markers》2013,35(6):701-710
The purpose of this study was to evaluate the association between ATM, TP53 and MDM2 polymorphisms in prostate cancer patients and morbidity after radiotherapy. The presence of ATM (rs1801516), TP53 (rs1042522, rs1800371, rs17878362, rs17883323, and rs35117667), and MDM2 (rs2279744) polymorphisms was assessed by direct sequencing of PCR fragments from 48 patients with histologically proven prostate adenocarcinoma and treated with external beam radiation. The side effects were classified according to the Radiation Therapy Oncology Group (RTOG) score. The results showed no association between clinical characteristics and the development of radiation toxicities (P > 0.05). The C>T transition in the position 16273 (intron 3) of TP53 (rs35117667) was significantly associated with the risk of acute skin toxicity (OR: 0.0072, 95% CI 0.0002–0.227, P = 0.003). The intronic TP53 polymorphism at position 16250 (rs17883323) was associated with chronic urinary toxicity (OR: 0.071, 95%CI 0.006–0.784, P = 0.032). No significant associations were found for the remaining polymorphisms (P > 0.05). The results show that clinical characteristics were not determinant on the developing of radiation sensitivity in prostate cancer patients, and intronic TP53 polymorphisms would be associated with increased acute and chronic radiation toxicities. These observations corroborate the importance of investigating the genetic profile to predict adverse side effects in patients undergoing radiotherapy. 相似文献
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Huiqiong Deng Ramandeep S. Kahlon Satyajit Mohite Pooja A. Amin Giovana Zunta-Soares Gabriela D. Colpo Laura Stertz Gabriel R. Fries Consuelo Walss-Bass Jair C. Soares Olaoluwa O. Okusaga 《The Psychiatric quarterly》2018,89(1):53-60
S100B is a calcium binding protein mainly produced by glial cells. Previous studies have shown elevated levels of S100B in patients with schizophrenia. We measured S100B levels in fasting plasma of 39 patients with schizophrenia and 19 adult healthy controls. We used linear regression to compare S100B between patients and controls. In patients only, we also investigated the relationship between S100B levels and psychotic symptoms (assessed by the Positive and Negative Syndrome Scale), and cognitive function (assessed by the NIH Toolbox Cognition Battery), respectively by calculating Pearson’s correlation coefficients. Mean plasma S100B was significantly higher in the patient group than in the control group. There were no significant correlations between plasma S100B and psychotic symptoms or cognition. 相似文献
79.
Soares Mayara Sandrielly Pereira Viau Cassiana Macagnan Saffi Jenifer Costa Marcelo Zanusso da Silva Tatiane Morgana Oliveira Pathise Souto Azambuja Juliana Hofstatter Barschak Alethéa Gatto Braganhol Elizandra S Wyse Angela T Spanevello Roselia Maria Stefanello Francieli Moro 《Metabolic brain disease》2017,32(5):1693-1703
Metabolic Brain Disease - High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia... 相似文献
80.
Bernard Salame Gemaque Alex Junior Souza de Souza Manoel do Carmo Pereira Soares Andreza Pinheiro Malheiros Andrea Lima Silva Max Moreira Alves Michele Soares Gomes-Gouvêa Jo?o Renato Rebello Pinho Heriberto Ferreira de Figueiredo Djacy Barbosa Ribeiro Jonan Souza da Silva Leopoldo Augusto Moraes Ana Silvia Sardinha Ribeiro Washington Luiz Assun??o Pereira 《Emerging infectious diseases》2014,20(12):2180-2182