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31.
Molecular basis for functional disorders of phagocytes 总被引:4,自引:0,他引:4
R L Baehner 《The Journal of pediatrics》1974,84(3):317-327
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Robert L. Baehner Irwin D. Bernstein Harland Sather Gussie Higgins Samuel McCreadie Ronald L. Chard Denman Hammond 《Pediatric blood & cancer》1979,7(2):127-139
In 163 children with acute nonlymphocytic leukemia (ANLL), a D-ZAPO induction program consisting of daunomycin, 5-azacytidine, cytosine arabinoside, prednisone, and vincristine resulted in a remission rate of 71.8%. Immunologic therapy was employed during maintenance with the aim of prolonging remission and improving survival. The administration of immunotherapy consisting of a mixture of bacillus Calmette-Guérin (BCG) and allogeneic acute myelomonocytic leukemic cells injected intradermally on day 14 of each of the first three monthly cycles of 6-thioguanine for ten days, 5-azacytidine and cytosine arabinoside for four days, and vincristine for one day did not improve remission duration or survival compared to that due to chemotherapy alone. Important prognostic factors identified in this study included a remission induction rate significantly better for females than males (P = 0.04), for children between the ages of 5 and 10 years compared to those greater than this age group (P = 0.01), and a prolonged remission duration (P = 0.04), and survival (P < 0.01) for patients with initial white blood counts of <20 × 109/liter. 相似文献
35.
Two hundred six technetium-99m sulfur colloid bone marrow scans in 110 pediatrics patients were reviewed. The normal distribution of sulfur colloid in the lower extremities in various age groups was established. There was progressive loss of uptake with increasing age from less than two years to greater than ten years. Tumor replacement was seen as regions of decreased radioactivity, and the extent of the scan defect paralleled the response of the disease to therapy. Both chemotherapy and irradiation resulted in an extension of the Tc-99m SC to peripheral marrow sites. In irradiated areas, marrow scan defects were demonstrated and generally recovered normal activity by six months after the completion of therapy. Marrow scan abnormalities caused by tumor replacement were present in four patients despite normal bone scans and radiographs. Ultimate confirmation of tumor involvement was by needle aspiration or biopsy. Persistent marrow defects were seen in two patients with neuroblastoma who had remission of their disease: biopsy revealed myelofibrosis. Technetium-99m sulfur colloid bone marrow scanning is a sensitive monitor of altered marrow activity associated with pediatric hematologic or oncologic diseases. 相似文献
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目的:评价308nm准分子激光联合他克莫司软膏治疗面部白癜风的疗效。方法:对656例面部白癜风患者照射308nm准分子激光联合外用他克莫司软膏。他克莫司软膏每日2次,308nm准分子激光每周治疗1-2次,共治疗30次。末次治疗后随访1年。结果:1630块白斑中,总有效率为47.12%,病程<2年皮损总有效率为58.10%高于病程≥2年皮损的16.60%,两组差异具有统计学意义(P<0.001)。眼周皮损疗效最佳,总有效率为54.96%,口周皮损疗效最差,总有效率为40.22%,差异有统计学意义(P<0.0001)。结论:308 nm准分子激光联合他克莫司软膏治疗面部白癜风的疗效与病期和皮损部位有关。 相似文献
38.
目的研究安氏Ⅰ类错患者中,采用微型种植体作支抗,压低下颌磨牙的临床效果及其作用特点。方法选择12例成人患者,将24枚微型种植体植于下颌第一磨牙近、远中的颊侧牙槽骨内,Ni-Ti螺旋弹簧拉长后分别连接于下颌第一磨牙带环颊侧,来压低下颌第一磨牙。测量磨牙的压低量、颊舌向的位置变化、近远中倾斜度以及磨牙移动的速度,并通过治疗前后的X线片对比以观察磨牙牙根有无吸收,牙周膜腔的变化情况。通过测量下颌第二磨牙与下颌中切牙的位置变化来衡量支抗强弱。结果下颌第一磨牙平均压低3.5mm,疗程5.2个月,平均移动速度0.67mm/月;磨牙牙冠近颊尖、远颊尖分别颊向移动1.2mm、1.3mm。磨牙牙根没有吸收,牙周膜腔宽度没有改变。下颌第二磨牙与下颌中切牙的位置没有改变。结论所有下颌磨牙均被压低到了恰当的位置,为对颌牙的修复治疗提供了足够的间隙。同时该方法临床操作简单易行,适于推广。 相似文献
39.
A. Touré D. Cissé KJJO. Kadio A. Camara FA. Traoré A. Delamou S. Sididé C. Kouyaté IS. Bangoura MM. Diallo TM. Tounkara F. Traoré MS. Sow N. Khanafer M. Cissé 《Revue d'épidémiologie et de santé publique》2018,66(4):273-279
Background
Late or inadequate therapeutic management increases the risk of mortality associated with HIV/AIDS. The aim of this study was to analyze the proportion and factors associated with loss of follow-up in HIV patients who receiving antiretroviral therapy at Conakry.Methods
A retrospective cohort study was conducted in HIV patients aged over 15 years and who receiving antiretroviral therapy. Between August 1, 2008 and July 31, 2015, all patients managed by the ambulatory treatment center of the Guinean Women Association against AIDS and sexually and transmissible infection were included. Loss of follow-up was defined as no follow-up visit within 3 months. Kaplan–Meier curves and multivariate Cox regression modelResults
614 patients aged 36.3 ± 11.2 years, mainly females (68.4%) and living in Conakry (80.5%) were included. Among them, 104 were loss to follow-up, corresponding to a proportion rate of 16.9% (95% CI: 14.2–19.7%) or 5.79/100 person-years. The results of multivariate analyses showed that factors independently associated with loss of follow-up were malnutrition (AHR = 7.05; 95% CI: 2.05–24.27; P = 0.002) and CD4 cells account at the initiation of AHR (2.35; 95% CI: 1.61–6.39; P = 0.016) in patients with 201–350 CD4/μL and 5.83 (95% CI: 2.85–11.90; P < 0.001) in patients with less than 150 CD4/μL.Conclusion
Despite efforts of health care workers and free antiretroviral therapy, many patients were loss to follow-up. Multivariate analysis showed that malnutrition and low CD4 account were independently associated with loss to follow-up. 相似文献40.