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31.
X Renming K Ishihara M Sasa H Ujihara T Momiyama Y Fujita N Todo T Serikawa J Yamada S Takaori 《European journal of pharmacology》1992,223(2-3):185-192
The effects of CNK-602A (N-[(6-methyl-5-oxo-3-thiomorpholinyl) carbonyl]-L-histidyl-L-prolinamide), a novel thyrotropin-releasing hormone related analog, were investigated on absence-like seizure and tonic convulsion in the spontaneously epileptic rat (SER), which is a genetically defined double-mutant. When CNK-602A of 0.2-1 mg/kg was given intravenously to the animal, there were no changes in the background EEG except for an increase in low-voltage fast waves concomitant with behavioral alertness. However, CNK-602A suppressed absence-like seizure and tonic convulsion in a dose-dependent manner for over 1 h. These antiepileptic effects of CNK-602A on both seizures were antagonized by pretreatment with haloperidol (1 mg/kg, i.p.). It was found, using a brain in vivo microdialysis method, that CNK-602A at a dose of 1 mg/kg, which inhibits the seizures, increased the release of dopamine in the caudate nucleus. These results suggest that CNK-602A inhibits the seizures of SER in a similar manner to thyrotropin-releasing hormone (TRH), probably by increasing the release of dopamine in the central nervous system. In addition, the antiepileptic effects of CNK-602A were more potent and lasted longer than those of TRH. 相似文献
32.
Takuo Fujita Masaaki Fukase Takao Shimada Hironosuke Yamamoto 《Journal of bone and mineral metabolism》1992,10(1):37-40
In addition to estrogen widely used all over the world for the prevention of postmenopausal osteoporosis, calcitonin and vitamin
D derivatives are commonly employed to treat established osteoporosis at higher age in Japan. In order to critically assess
the usefulness of vitamin D derivatives and calcitonin alone or in combination on the advancement of vertebral deformity at
higher age, 32 osteoporotic patients with vertebral deformity with the mean age of 79 were randomly divided into 4 groups
with indistinguishable age and severity of the vertebral deformity. Group 1 served as the control without specific medications
for osteoporosis. Group 2 was treated with 10 units elcatonin (eel calcitonin derivative) injected intramuscularly twice a
week. Group 3 was given 0.75 to 1.5μg/day 1α (OH) vitamin D3 orally. Group 4 was given a combination of treatments used in Groups 2 and 3.
In the lateral X-ray film of the spine taken prior to the test and every 6 months thereafter, the shape of the vertebral body
T8 through L4 was monitored by measuring the anterior, central and posterior heights. Decrease of the vertebral height ratio; anterior
or middle height/posterior or adjacent intact posterior height, by more than 20% of the original value or from above to below
0.80 both appeared to be inhibited during administration of 1α (OH) vitamin D3. Such effect seems to be augmented by simultaneous administration of elcatonin. Actual decrease of vertebral height ratio
values and the per cent fall from the original value significantly less in Groups 3 and 4 than in Group 1. Development of
vertebral deformity assessed by the changes of the vertebral height thus appears to decrease during treatment with 1α (OH) vitamin D3 especially together with calcitonin in established osteoporosis. 相似文献
33.
H Hanyu H Arai H Katsunuma R Fujita C Tomori 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》1991,28(2):160-165
A neuroradiological study of crossed cerebellar atrophy (CCA) was performed using X-ray CT in 103 patients suffering from unilateral supratentorial cerebrovascular diseases. CCA was demonstrated in 9 (8.7%) of 103 patients. No difference between the occurrence of CCA in cerebral hemorrhage and that in cerebral infarction was found. CCA was seen in the chronic stage of cerebrovascular disease more than 3 years since stroke occurrence, and was found to be present more frequently and to a greater extent 7 years later. No correlation between the site of bleeding and the occurrence of CCA was found. Trans-synaptic degeneration of the corticopontocerebellar tract was considered in CCA following putaminal and combined hemorrhage involving an internal capsule lesion. However, in thalamic hemorrhage, retrograde degeneration within the cerebellorubrothalamic tract was presumed. CCA following cerebral infarction was seen in patients with massive lesions in the territory of the middle cerebral artery. Multivariate analysis showed that lesions of the parietal and frontal lobes appeared to greatly contribute to the development of CCA. As the degeneration and atrophy in the thalamus on the side of the lesion appeared early and frequently, it was suggested that retrograde degeneration of the cerebellorubrothalamic tract participated, in addition to anterograde corticopontocerebellar tract degeneration, in CCA following middle cerebral artery infarction. It is likely that CCA is caused by both transsynaptic degeneration of the corticopontocerebellar tract and the cerebellorubrothalamic tract. 相似文献
34.
Ishizaki K.; Yoon D. M.; Yoshida N.; Yamazaki M.; Arai K.; Fujita T. 《British journal of anaesthesia》1995,75(5):636-638
We have studied the effect of intrathecal administration of N-methyl-D-
aspartate (NMDA) receptor antagonists on the minimum alveolar anaesthetic
concentration (MAC) of isoflurane in rats. In Wistar rats fitted with
indwelling intrathecal catheters, we determined the MAC of isoflurane after
administration of a competitive NMDA receptor antagonist, APV (0.01, 0.1,
1.0, 10, 30 micrograms), a non-competitive NMDA receptor antagonist, MK801
(0.1, 1.0, 10, 30 micrograms). NMDA (0.01, 0.1, 1.0, 10, 30 micrograms) and
saline. APV at all doses except 0.01 micrograms decreased MAC by 17.1-32%
(P < 0.001 and P < 0.0001). Although MK801 at 10 and 30 micrograms
reduced MAC by 24.3-31.7% (P < 0.001 and P < 0.0001), lower doses did
not affect MAC. Intrathecal administration of NMDA reversed these decreases
in MAC, but not to control values with APV 10 and 30 micrograms and MK801
30 micrograms. We suspect that NMDA and NMDA receptor antagonists play
important roles in the spinal cord in determining the MAC of isoflurane.
相似文献
35.
Hisashi Masugata Shoichi Senda Fuminori Goda Yumiko Yoshihara Kay Yoshikawa Norihiro Fujita Hiroyuki Daikuhara Hiroyuki Nakamura Teruhisa Taoka Masakazu Kohno 《Hypertension research》2006,29(11):897-903
The purpose of the present study was to elucidate the cardiac structure and function in patients who have metabolic syndrome but no history of cardiovascular disease by analyzing echocardiographic findings. Echocardiographic examination was performed to screen for cardiovascular disease in 135 patients who were in their sixties. Patients were divided into metabolic syndrome (n=65, age: 65+/-2.7 years) and non-metabolic syndrome (n=70, age: 66+/-2.5 years) groups based on the criteria for metabolic syndrome proposed by the Japanese Society of Hypertension and seven other societies in 2005. The left ventricular (LV) wall thickness and dimension were measured by M-mode echocardiography. The relative wall thickness, LV mass index, and LV ejection fraction (LVEF) were calculated. LV diastolic function was assessed by the peak velocity of early rapid filling (E velocity) and the peak velocity of atrial filling (A velocity), and the ratio of E to A (E/A) was assessed by the transmitral flow. The Tei index, which reflects both LV diastolic and systolic function, was also calculated. There were no differences in relative wall thickness, LV mass index, or LVEF between the two groups. However, both the EIA and Tei index were significantly different between the metabolic syndrome (0.66+/-0.14 and 0.36+/-0.07, respectively) and non-metabolic syndrome (0.88+/-0.25 and 0.29+/-0.09) groups (p<0.001). These results indicate that patients with metabolic syndrome can have cardiac diastolic dysfunction even if they have neither LV hypertrophy nor systolic dysfunction. 相似文献
36.
37.
K. L. Womer H.-U. Meier-Kriesche P. R. Patton K. Dibadj C. M. Bucci D. Foley S. Fujita B. P. Croker R. J. Howard T. R. Srinivas B. Kaplan 《American journal of transplantation》2006,6(1):209-213
BK virus nephropathy (BKVN) is now recognized as a major cause of renal allograft loss. Recent reports suggest that retransplantation in patients with graft loss due to BKVN is safe after return to dialysis. Since early transplantation is associated with improved outcomes, it would be advantageous if this procedure could be performed prior to ultimate graft loss. However, little data are available regarding the safety of this approach during active viremia. In this report, we describe successful preemptive retransplantation with simultaneous allograft nephrectomy in two patients with active BKVN and viremia at the time of surgery. With 21- and 12-month follow-up, respectively, both patients have stable allograft function and no evidence for active viral replication. We conclude that preemptive retransplantation can be considered in patients with failing allografts due to BKVN. 相似文献
38.
Lung cancer mortality rates among United States and Japanese males were compared and related to smoking and dietary data. Mortality rates increased from 1950 to 1985 in both countries, but the absolute values are consistently lower in Japan (38.2 deaths/100,000 in 1985) than in the U.S. (72.2/100,000). The proportion of smokers is higher in Japan than in the U.S. since 1955. Japanese males start smoking considerably later than U.S. males, but smoke a higher quantity of cigarettes per day. Available information on inhalation practices and yield and type of cigarettes smoked showed no differences among the two countries large enough to account for the differences in mortality rates. Further data in this regard should he obtained. Dietary data show that fat consumption (as percentage of calories) is consistently higher in the U.S. than in Japan from 1950 (40% vs. 7.9%) through 1985 (43.5% vs. 24.5%). A linear relationship is observed between lung cancer mortality and fat intake. Our data support the hypothesis that dietary habits may modulate the carcinogenic effects of tobacco smoking. 相似文献
39.
40.