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Mark Swerdlow MD MSc FFARCS Consultant J.G. Cundill MB ChB BSc Registrar 《Anaesthesia》1981,36(12):1129-1132
The value of anticonvulsant drugs in the treatment of some cases of lancinating pain is now established. The results in 170 consecutive cases in an ongoing series are reported with special reference to the efficacy of four anticonvulsants--carbamazepine, clonazepam, phenytoin and valproate. The findings are discussed. 相似文献
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R. D. SUCKLING FRACO FRACS FRCS K. F. MASLIN MB ChB 《Clinical & experimental ophthalmology》1988,16(4):353-359
The treatment of 26 cases of cystoid macular oedema following cataract extraction is reviewed. Cases treated early and more aggressively with betamethazone drops and subtenons injection of methyl-prednisolone, responded well to treatment. Those given later and fess aggressive treatment had a less satisfactory outcome. Our results would suggest that local steroids are effective in the treatment of pseudophakic cystoid macular oedema. 相似文献
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Assessment of gross motor skills of at-risk infants: predictive validity of the Alberta Infant Motor Scale 总被引:3,自引:1,他引:2
Johanna Darrah PhD PT Martha Piper PhD Man-Joe Watt MB BS FRCP FAAEM 《Developmental medicine and child neurology》1998,40(7):485-491
The Alberta Infant Motor Scale (AIMS) is a norm-referenced measure of infant gross motor development. The objectives of this study were: (1) to establish the best cut-off scores on the AIMS for predictive purposes, and (2) to compare the predictive abilities of the AIMS with those of the Movement Assessment of Infants (MAI) and the Peabody Developmental'Gross Motor Scale (PDGMS). One hundred and sixty-four infants were assessed at 4 and 8 months adjusted ages on the three measures. A pediatrician assessed each infant's gross motor development at 18 months as normal, suspicious, or abnormal. For the AIMS, two different cut-off points were identified: the 10th centile at 4 months and the 5th centile at 8 months. The MAI provided the best specificity rates at 4 months while the AIMS was superior in specificity at 8 months. Sensitivity rates were comparable between the two tests. The PDGMS in general demonstrated poor predictive abilities. 相似文献
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The effects of aging on layer 1 in area 46 of prefrontal cortex in the rhesus monkey 总被引:6,自引:3,他引:3
The effect of age on layer 1 of area 46 of prefrontal cortex was determined
in the cerebral cortices of 15 rhesus monkeys, 13 of which had been
behaviorally tested. Five of the monkeys were young (5-7 years of age),
three were middle-aged (9-12 years) and seven were old (24-32 years). It
was found that with age, layer 1 becomes significantly thinner and the
glial limiting membrane becomes thicker. Counts of synapses in layer 1 of
seven of these monkeys using the physical disector method on thin sections
revealed that compared to young monkeys, there is a 30-60% reduction in the
density of synapses per unit volume in old monkeys. This loss of synapses
is accompanied by a reduction in the frequency of profiles of postsynaptic
dendrites and their spines from the neuropil of layer 1, indicating that
some spiny dendrites that belong to the apical dendritic tufts of pyramidal
cells are degenerating and being lost with age. Correlation of these
morphological changes with the behavioral data shows that there is a
significant correlation between the thickness of layer 1 and memory
function, as measured by the 2 min delay condition of the delayed non-
matching to sample task. Also, there is significant correlation between the
numerical density of synapses in layer 1 and three of the behavioral
measures used, as well as the Cognitive Impairment Index. Thus, the changes
that occur with age in layer 1 provide one possible basis for the
age-related cognitive impairment evidenced in monkeys and humans alike.
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