全文获取类型
收费全文 | 2086篇 |
免费 | 126篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 144篇 |
妇产科学 | 95篇 |
基础医学 | 225篇 |
口腔科学 | 67篇 |
临床医学 | 196篇 |
内科学 | 520篇 |
皮肤病学 | 24篇 |
神经病学 | 157篇 |
特种医学 | 149篇 |
外科学 | 235篇 |
综合类 | 13篇 |
一般理论 | 1篇 |
预防医学 | 150篇 |
眼科学 | 23篇 |
药学 | 141篇 |
中国医学 | 3篇 |
肿瘤学 | 83篇 |
出版年
2022年 | 16篇 |
2021年 | 38篇 |
2020年 | 32篇 |
2019年 | 39篇 |
2018年 | 54篇 |
2017年 | 35篇 |
2016年 | 41篇 |
2015年 | 43篇 |
2014年 | 38篇 |
2013年 | 76篇 |
2012年 | 108篇 |
2011年 | 131篇 |
2010年 | 81篇 |
2009年 | 64篇 |
2008年 | 114篇 |
2007年 | 121篇 |
2006年 | 88篇 |
2005年 | 86篇 |
2004年 | 64篇 |
2003年 | 63篇 |
2002年 | 55篇 |
2001年 | 63篇 |
2000年 | 47篇 |
1999年 | 39篇 |
1998年 | 53篇 |
1997年 | 57篇 |
1996年 | 58篇 |
1995年 | 48篇 |
1994年 | 37篇 |
1993年 | 39篇 |
1992年 | 29篇 |
1991年 | 23篇 |
1990年 | 20篇 |
1989年 | 34篇 |
1988年 | 31篇 |
1987年 | 34篇 |
1986年 | 25篇 |
1985年 | 26篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 9篇 |
1980年 | 10篇 |
1979年 | 14篇 |
1978年 | 12篇 |
1977年 | 16篇 |
1976年 | 15篇 |
1975年 | 12篇 |
1974年 | 9篇 |
1970年 | 8篇 |
1966年 | 8篇 |
排序方式: 共有2241条查询结果,搜索用时 669 毫秒
21.
22.
Two additional families with popliteal pterygium syndrome are presented. Using previously published pedigrees, as well as the ones reported here, evidence is presented that supports an autosomal dominant mode of inheritance for this syndrome. Analysis of previous familial cases showed a large degree of between and within-family variation. The segregation analysis supports the dominant hypothesis (P=0.5). 相似文献
23.
A 63-year-old man with iron loss anaemia and hypercalcaemia was found to have a renal cell carcinoma. Despite the iron-deficient blood and bone marrow picture, the serum ferritin concentration was markedly raised. This was mainly due to a “basic isoferritin”. The serum parathormone concentration was normal. The serum ferritin and calcium concentrations returned to normal after the tumour was removed. We propose that the renal cell carcinoma cells in this patient secreted the basic isoferritin as well as humoral factor(s) responsible for hypercalcaemia. 相似文献
24.
Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis 总被引:7,自引:2,他引:7
Li DY; Toland AE; Boak BB; Atkinson DL; Ensing GJ; Morris CA; Keating MT 《Human molecular genetics》1997,6(7):1021-1028
Supravalvular aortic stenosis (SVAS) is an inherited obstructive vascular
disease that affects the aorta, carotid, coronary and pulmonary arteries.
Previous molecular genetic data have led to the hypothesis that SVAS
results from mutations in the elastin gene, ELN. In these studies, the
disease phenotype was linked to gross DNA rearrangements (35 and 85 kb
deletions and a translocation) in three SVAS families. However, gross
rearrangements of ELN have not been identified in most cases of autosomal
dominant SVAS. To define the spectrum of ELN mutations responsible for this
disorder, we refined the genomic structure of human ELN and used this
information in mutational analyses. ELN point mutations co-segregate with
the disease in four familial cases and are associated with SVAS in three
sporadic cases. Two of the mutations are nonsense, one is a single base
pair deletion and four are splice site mutations. In one sporadic case, the
mutation arose de novo. These data demonstrate that point mutations of ELN
cause autosomal dominant SVAS.
相似文献
25.
Morphological analysis of degeneration and regeneration of syncytiotrophoblast in first trimester placental villi during organ culture 总被引:3,自引:1,他引:3
We have recently shown using dansyl-L-lysine exclusion studies that the
release of human chorionic gonadotrophin (HCG) in conjunction with L-
lactate dehydrogenase (LDH) from first trimester villi during organ culture
is symptomatic of syncytiotrophoblast degeneration. The purpose of this
study was to examine chorionic villi at the ultrastructural level in order
to determine events occurring during organ culture. The tissue was sampled
after 0, 24, 48 and 120 h in culture and processed for electron microscopy.
In addition to confirming the previously recorded syncytial degeneration,
the electron micrographs showed clearly the generation of a new
syncytiotrophoblast layer. The new layer, derived from differentiating
cytotrophoblast cells, was largely formed by 48 h and was maintained for at
least 120 h in culture. This study demonstrates a model which provides an
opportunity to study the differentiation of cytotrophoblast cells whilst
they retain their anatomical relationships within the villous structure.
相似文献
26.
Sá DR Souza-Santos R Escobar AL Coimbra CE 《Bulletin de la Societe de pathologie exotique (1990)》2005,98(1):28-32
This paper reports the results of a longitudinal study of malaria incidence (1998-2002) among the Pakaanóva (Wari') Indians, Brazilian southwest Amazon region, based on data routinely gathered by Brazilian National Health Foundation outposts network in conjunction with the Indian health service. Malaria is present yearlong in the Pakaanóva. Statistically significant differences between seasons or months were not noticed. A total of 1933 cases of malaria were diagnosed in the Pakaanóva during this period. The P. vivax / P. falciparum ratio was 3.4. P. vivax accounted for 76.5% of the cases. Infections with P. malariae were not recorded. Incidence rates did not differ by sex. Most malaria cases were reported in children < 10 years old (45%). About one fourth of all cases were diagnosed on women 10-40 years old. An entomological survey carried out at two Pakaanóva villages yielded a total of 3.232 specimens of anophelines. Anopheles darlingi predominated (94.4%). Most specimens were captured outdoors and peak activity hours were noted at early evening and just before sunrise. It was observed that Pakaanóva cultural practices may facilitate outdoor exposure of individuals of both sexes and all age groups during peak hours of mosquito activities (e.g., coming to the river early in the morning for bathing or to draw water, fishing, engaging in hunting camps, etc). In a context in which anophelines are ubiquitous and predominantly exophilic, and humans of both sexes and all ages are prone to outdoor activities during peak mosquito activity hours, malaria is likely to remain endemic in the Pakaanóva, thus requiring the development of alternative control strategies that are culturally and ecologically sensitive. 相似文献
27.
Javier I. Escobar David J. Lakatua Barbara Streifel Norman L. Virnig Otto Sanchez 《Clinical genetics》1977,11(1):8-12
An abnormal chromosome No. 2 was found in the case of a child with an imperforate anus, a recto-vaginal fistula, unilateral atresia of the inner canal, and deformity of the external ear. G-banding studies revealed an insertion of a segment of the short arm into the long arm in one of the chromosomes No. 2 of the proband, the apparent result of a de novo phenomenon of chromosome rearrangement. 相似文献
28.
On the classification of the acrocephalosyndactyly syndromes 总被引:2,自引:0,他引:2
This report describes a family in which two different types of acrocephalosyndactyly (ACS) were clinically identified. The proband presented with the classic stigmata of Pfeiffer syndrome, while her cousin was considered to be a typical case of Apert syndrome. Seven other family members also have unusually shaped heads and the facial appearance reminiscent of Crouzon disease.
Observations made in this family and from previous reports in the literature, we feel there is substantial reason to re-evaluate the ACS classification and to consider that the Apert and Pfeiffer types of ACS may be one and the same. 相似文献
Observations made in this family and from previous reports in the literature, we feel there is substantial reason to re-evaluate the ACS classification and to consider that the Apert and Pfeiffer types of ACS may be one and the same. 相似文献
29.
L. Torres S. Escobar A. López M. Marco V. Pobo 《European journal of clinical microbiology & infectious diseases》2002,21(7):537-538
Vibrio vulnificus is a gram-negative rod that can cause septicaemia and skin lesions, usually in patients with underlying illnesses such as
chronic liver disease or diabetes mellitus. Infections caused by this bacterium are unusual in Spain. A case of skin infection
due to Vibrio vulnificus is reported in a patient whose abraded skin on his left leg came into contact with seawater. The patient died suddenly, probably
due to septicaemia or bacteraemia caused by this organism. Vibrio vulnificus infection must be considered in the differential diagnosis of septicaemia, skin lesions and wound infections, particularly
when a patient reports a history of contact with seawater.
Electronic Publication 相似文献
30.