全文获取类型
收费全文 | 234篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 43篇 |
口腔科学 | 4篇 |
临床医学 | 14篇 |
内科学 | 72篇 |
皮肤病学 | 2篇 |
神经病学 | 10篇 |
特种医学 | 2篇 |
外科学 | 30篇 |
预防医学 | 14篇 |
眼科学 | 1篇 |
药学 | 13篇 |
肿瘤学 | 31篇 |
出版年
2021年 | 5篇 |
2020年 | 11篇 |
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 8篇 |
2012年 | 17篇 |
2011年 | 17篇 |
2010年 | 10篇 |
2009年 | 10篇 |
2008年 | 14篇 |
2007年 | 10篇 |
2006年 | 14篇 |
2005年 | 22篇 |
2004年 | 19篇 |
2003年 | 9篇 |
2002年 | 12篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1987年 | 2篇 |
1984年 | 2篇 |
1981年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有241条查询结果,搜索用时 0 毫秒
11.
Dragani A Di Bartolomeo E La Barba G Cavoni A Lanzillotta P Guizzardi G Davì G 《Aging clinical and experimental research》2004,16(6):487-489
Acquired hemophilia is a life-threatening condition associated with a high mortality, occurring mainly in elderly patients. We report on a 92-year-old male, administered two courses of 90 microg kg(-1) of recombinant activated factor VII (rFVIIa) due to failure of human factor VIII (FVIII) therapy, without side effects nor evidence of thrombotic complications. Despite the bleeding being completely under control, the patient died on day 11 of acute respiratory failure due to pneumonia. This case confirms previous reports on the complexity and severity of this disorder, showing that rFVIIa is an effective and safe agent for achieving hemostasis even in elderly patients with a FVIII inhibitor. 相似文献
12.
Serrao Alessandra Lucani Benedetta Assanto Manfredi Giovanni Fiori Luciano Baldacci Erminia Aprile Simona Michela Chistolini Antonio 《Journal of thrombosis and thrombolysis》2020,50(3):718-723
Journal of Thrombosis and Thrombolysis - Anticoagulant therapy has undergone a significant change since direct oral anticoagulants (DOACs) introduction. Their obvious advantages including the fixed... 相似文献
13.
Pulsatelli L Dolzani P Silvestri T Caraceni P Facchini A Ravaglia G Salvarani C Melicòni R Mariani E 《Biogerontology》2004,5(2):119-127
Recently, novel members of the TNF/TNF receptor superfamily, receptor activator of nuclear factor- kappa B ligand (RANKL), its receptor RANK, and the decoy receptor osteoprotegerin (OPG), have been identified as paracrine mediators of both the immune system and bone functions. The balance of RANK/RANK-L and OPG is critical for osteoclastogenesis modulation and physiological bone remodeling. In order to evaluate whether RANKL/OPG balance is modified by ageing, we analyzed, by imunoassay, systemic levels of OPG and sRANKL in healthy elderly subjects (age range from 70 to over 90 years) and in patients affected by two age-related diseases, osteoarthritis (OA) and polymyalgia rheumatica (PMR), characterized by bone metabolism alteration and involvement of the immune system. We demonstrated that (a) plasma concentrations of OPG increased significantly with age; (b) conversely, sRANKL significantly declined in the group of subjects aged between 81 and 90 years, being similar to the young controls in the other age groups; (c) in OA and PMR, circulating OPG did not differ from plasma levels found in age-matched control groups, while sRANKL concentration was significantly increased compared to controls. Hence, in ageing, the sRANKL/OPG system appears to be modified, with prominent changes in circulating OPG levels; in OA and PMR, the sRANKL/OPG balance alteration was shown to be mainly due to the increase of plasma sRANKL concentration. 相似文献
14.
M. Makatsori G. W. Scadding C. Lombardo G. Bisoffi E. Ridolo S. R. Durham G. Senna 《Allergy》2014,69(5):571-580
Participant dropouts can reduce the power of allergen immunotherapy clinical trials. Evaluation of the dropout rate and reasons for dropout are important not only in the planning of clinical studies but are also relevant for adherence to immunotherapy in daily clinical practice. A systematic review was carried out in order to establish the overall dropout rate among published double‐blind, placebo‐controlled randomized clinical trials of sublingual immunotherapy for respiratory allergic diseases. Dropouts were analysed in regards to allergen, formulation, treatment schedule, participant age, study size, number of centres and type of allergic disease. Relative dropout rates in placebo and active groups as well as reasons for dropout were also assessed. A total of 81 studies, comprising 9998 patients, were included. Dropout rates in sublingual immunotherapy controlled studies do not appear to be a major problem with a composite dropout percentage of 14% (95% CI:11.9–16). Furthermore, they are not different for active compared to placebo‐treated participants. This lends support to the positive clinical outcomes seen in meta‐analyses of these trials. 相似文献
15.
16.
Ravaglia G Forti P Maioli F Sacchetti L Mariani E Nativio V Talerico T Vettori C Macini PL 《Dementia and geriatric cognitive disorders》2002,14(2):90-100
Information about the epidemiology of dementia in Italy is still limited, although this cognitive disorder represents a serious public health concern. We estimated the prevalence of dementia and dementia subtypes in the elderly population of a Northern Italian municipality, Conselice, in the Emilia Romagna region (n = 1,016 subjects aged 65-97 years). The associations of dementia with two modifiable risk factors, education and occupation, were also evaluated. Overall dementia prevalence was 5.9% (95% confidence interval 4.3-7.8), exponentially increased with age, and was higher among women. Of the dementia cases, 50% were Alzheimer's disease (AD), but an unusually high prevalence (45%) was found for vascular dementia (VD). After adjustment for age and gender, education but not occupation was associated with both AD and VD. This association could not be explained by occupation, life habits, and previous history of hypertension or cardiovascular disease. 相似文献
17.
18.
Loss of E-cadherin and p27 expression is associated with head and neck squamous tumorigenesis 总被引:6,自引:0,他引:6
Massarelli E Brown E Tran NK Liu DD Izzo JG Lee JJ El-Naggar AK Hong WK Papadimitrakopoulou VA 《Cancer》2005,103(5):952-959
BACKGROUND: In neoplastic head and neck lesions, it has been found that the loss or reduction in E-cadherin expression is a late event and is associated with invasion. Low p27 levels have been associated with a poor prognosis in many different tumors, including laryngeal carcinoma. The authors investigated p27 and E-cadherin protein expression in the early stages of head and neck tumorigenesis and evaluated their predictive roles individually and in association with carcinogenesis. METHODS: Tissue biopsies from 46 patients who were participants in 3 chemoprevention trials were analyzed for E-cadherin expression, and 40 samples were analyzed for p27 expression using immunohistochemistry. RESULTS: The data suggested that loss of both E-cadherin expression and p27 expression occurred early during the preneoplastic steps of head and neck carcinogenesis, and loss of p27 protein expression alone (P=0.02) and in combination with loss of E-cadherin expression (P=0.04) was a significant predictor of the risk for head and neck carcinoma. CONCLUSIONS: The loss of p27 expression may be useful in the construction of a risk model for head and neck carcinogenesis and may represent a potential target for chemopreventive interventions. Longer follow-up of the high percentage of low-risk preneoplastic lesions in the current study and validation in a larger sample size may be required to establish the predictive role of these abnormalities. 相似文献
19.
Chemokine production by natural killer cells from nonagenarians 总被引:1,自引:0,他引:1
Mariani E Meneghetti A Neri S Ravaglia G Forti P Cattini L Facchini A 《European journal of immunology》2002,32(6):1524-1529
In this study we investigated whether purified NK cells, derived from a group of nonagenarian healthy subjects, were able to produce the chemokines MIP-1alpha, RANTES and IL-8, and also characterized the effect of IL-12 or IL-2 immunomodulatory cytokines (that are among the most effective inducers of NK lytic activity and soluble factor secretion) on the induction, in vitro, of these chemokines and on the modulation of the corresponding receptors. This study provides evidence that human NK cells from healthy subjects over 90 years old retain the ability to synthesize MIP-1alpha, Rantes and IL-8 chemotactic cytokines, that NK cells isolated from these subjects can be activated to significantly up-regulate the production of these chemokines in response to stimulation by IL-12 or IL-2 cytokines (even though production remains lower than that observed in young subjects), and that NK cells express the corresponding chemokine receptors. 相似文献
20.
Palmas Maria Antonietta Cherchi Alessandra Stochino Erminia Congiu Donatella Del Zompo Maria 《The journal of headache and pain》2000,1(2):S153-S156
Migraine is a common chronic disorder with an etiology still mostly unknown. Several neurotransmitters such as dopamine and serotonin are considered to be involved in the pathogenesis of the disease and the study of their systems is crucial in the understanding of migraine. Dopaminergic receptors are variously represented in human CNS and periphery. The hypothesis that a hypersensitivity of the dopaminergic system may have a role in migraine is based on clinical and genetic data. Genetic data are represented by association studies using dopaminergic genes as candidate genes which show that the D2 receptor gene appears to be involved in the pathogenesis of migraine. 相似文献