全文获取类型
收费全文 | 21827篇 |
免费 | 1362篇 |
国内免费 | 129篇 |
专业分类
耳鼻咽喉 | 201篇 |
儿科学 | 576篇 |
妇产科学 | 548篇 |
基础医学 | 3456篇 |
口腔科学 | 320篇 |
临床医学 | 1787篇 |
内科学 | 5530篇 |
皮肤病学 | 550篇 |
神经病学 | 2347篇 |
特种医学 | 460篇 |
外科学 | 1939篇 |
综合类 | 82篇 |
一般理论 | 11篇 |
预防医学 | 1675篇 |
眼科学 | 433篇 |
药学 | 1513篇 |
中国医学 | 54篇 |
肿瘤学 | 1836篇 |
出版年
2024年 | 32篇 |
2023年 | 276篇 |
2022年 | 617篇 |
2021年 | 977篇 |
2020年 | 497篇 |
2019年 | 769篇 |
2018年 | 799篇 |
2017年 | 607篇 |
2016年 | 693篇 |
2015年 | 742篇 |
2014年 | 1016篇 |
2013年 | 1167篇 |
2012年 | 1799篇 |
2011年 | 1862篇 |
2010年 | 1033篇 |
2009年 | 929篇 |
2008年 | 1446篇 |
2007年 | 1470篇 |
2006年 | 1355篇 |
2005年 | 1256篇 |
2004年 | 1070篇 |
2003年 | 987篇 |
2002年 | 831篇 |
2001年 | 89篇 |
2000年 | 54篇 |
1999年 | 112篇 |
1998年 | 148篇 |
1997年 | 110篇 |
1996年 | 85篇 |
1995年 | 78篇 |
1994年 | 48篇 |
1993年 | 49篇 |
1992年 | 33篇 |
1991年 | 23篇 |
1990年 | 20篇 |
1989年 | 23篇 |
1988年 | 18篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 16篇 |
1980年 | 15篇 |
1978年 | 7篇 |
1975年 | 8篇 |
1974年 | 6篇 |
1971年 | 9篇 |
1966年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Sotiris Mastoridis María-Carlota Londoño Ada Kurt Elisavet Kodela Elena Crespo John Mason Oriol Bestard Marc Martínez-Llordella Alberto Sánchez-Fueyo 《American journal of transplantation》2021,21(7):2387-2398
In several murine models of transplantation, the “cross-dressing” of recipient antigen presenting cells (APCs) with intact donor major histocompatibility complex (MHC) derived from allograft-released small extracellular vesicles (sEVs) has been recently described as a key mechanism in eliciting and sustaining alloimmune responses. Investigation of these processes in clinical organ transplantation has, however, been hampered by the lack of sensitivity of conventional instruments and assays. We have employed advanced imaging flow cytometry (iFCM) to explore the kinetics of allograft sEV release and the extent to which donor sEVs might induce cross-dressing following liver and kidney transplantation. We report for the first time that recipient APC cross-dressing can be transiently detected in the circulation shortly after liver, but not kidney, transplantation in association with the release of HLA-bearing allograft-derived sEVs. In liver transplant recipients the majority of circulating cells exhibiting donor HLA are indeed cross-dressed cells and not passenger leukocytes. In keeping with experimental animal data, the downstream functional consequences of the transfer of circulating sEVs harvested from human transplant recipients varies depending on the type of transplant and time posttransplant. sEVs released shortly after liver, but not kidney, transplantation exhibit immunoinhibitory effects that could influence liver allograft immunogenicity. 相似文献
92.
Dane Christina Daoud MD Elena M. S. Cartagena MD MSc Katherine J. P. Schwenger RD PhD Nicha Somlaw MD Leah Gramlich MD Scott Whittaker MD David Armstrong MD Brian Jurewitsch PharmD Matreyi Raman MD Donald R. Duerksen MD James D. McHattie MD Johane P. Allard MD 《JPEN. Journal of parenteral and enteral nutrition》2022,46(2):348-356
93.
Riekie Smit Elena Gubanova Joely Kaufman Marina Landau Beatriz Molina Bill Andriopoulos Pascal Maisonobe Inna Prygova Alessio Redaelli 《The Journal of clinical and aesthetic dermatology》2021,14(2):E69
BACKGROUND: AbobotulinumtoxinA (AboBoNT-A; Dysport®; Ipsen, Boulogne-Billancourt, France/Azzalure®; Galderma, Lausanne, Switzerland) is a botulinum neurotoxin type A approved for aesthetic use in the treatment of glabellar lines in adult patients under 65 years in Europe, the United States, and other countries. OBJECTIVE: We sought to analyze current literature on patient satisfaction with aboBoNT-A for upper facial aesthetic indications. METHODS: A systematic review of literature databases (PubMed/MEDLINE, Embase, the Cochrane Library, and Google Scholar) was performed to identify English-language publications reporting on patients with aesthetic indications (including glabellar lines and wrinkles) receiving aboBoNT-A, that assessed patient and/or physician satisfaction with treatment, with no restrictions on comparator studies. Structured data extraction was used to enable inter-study analysis. A post-hoc analysis was also performed to assess patient satisfaction by sex and age, using results from the noninterventional APPEAL study of patients’ satisfaction with aboBoNT-A for treating glabellar lines. RESULTS: Overall, 22 original research papers were identified. Patient satisfaction rates for aboBoNT-A treatment were significantly higher versus placebo from two weeks to between three and five months postinjection. At two to three weeks postinjection, patient satisfaction rates were 52% and 99% across studies. In studies with later time points, patient satisfaction rates were 85 to 87 percent at 5 months and between 25 and 100 percent at 6 months post-injection. Physician satisfaction was also high (97%–100%, across three treatments). No notable differences in patient satisfaction by sex or age were observed in the APPEAL study. CONCLUSION: High rates of patient satisfaction have been achieved with aboBoNT-A treatment for upper facial aesthetic indications. Despite the current recommended interval of ≥12 weeks, satisfaction with the aesthetic results of aboBoNT-A therapy is still evident up to 6 months post-injection in some patients. 相似文献
94.
95.
Maria Neufeld Jürgen Rehm Anna Bunova Artyom Gil Boris Gornyi Pol Rovira Jakob Manthey Elena Yurasova Svetlana Dolgova Bulat Idrisov Marina Moskvicheva Galina Nabiullina Olga Shegaym Irina Zhidkova Zukhra Ziganshina Carina Ferreira-Borges the / RUS-AUDIT Collaborators the RUS-AUDIT Project Advisory Board 《Bulletin of the World Health Organization》2021,99(7):496
ObjectiveTo validate a Russian-language version of the World Health Organization’s Alcohol Use Disorders Identification Test (AUDIT).MethodsWe invited 2173 patients from 21 rural and urban primary health-care centres in nine Russian regions to participate in the study (143 declined and eight were excluded). In a standardized interview, patients who had consumed alcohol in the past 12 months provided information on their sociodemographic characteristics and completed the Russian AUDIT, the Kessler Psychological Distress Scale and the Composite International Diagnostic Interview to identify problem drinking and alcohol use disorders. We assessed the feasibility of administering the test, its internal consistency and its ability to predict hazardous drinking and alcohol use disorders in primary health care in the Russian Federation.FindingsOf the 2022 patients included in the study, 1497 were current drinkers with Russian AUDIT scores. The test was internally consistent with good psychometric properties (Cronbach’s α : 0.842) and accurately predicted alcohol use disorders and other outcomes (area under the curve > 75%). A three-item short form of the test correlated well with the full instrument and had similar predictive power (area under the curve > 80%). We determined sex-specific thresholds for all outcomes, as non-specific thresholds resulted in few women being identified.ConclusionWith the validated Russian AUDIT, there is no longer a barrier to introducing screening and brief interventions into primary health care in the Russian Federation to supplement successful alcohol control policies. 相似文献
96.
Antonio Iáñez-Domínguez Violeta Luque-Ribelles María Soledad Palacios-Gálvez Elena Morales-Marente 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2021,53(7):102060
ObjectiveTo know the perception and opinion of primary care health professionals on the impact of non-medicalizing group educational intervention (GRUSE) with women who present somatic symptoms without organic cause.DesignQualitative phenomenological study.SettingPrimary care health centers in Andalusia, during 2017 and 2018.Participants and/or contextsTwenty-four health professionals, selected according to their level of involvement in the GRUSE strategy (socio-educational groups).MethodA qualitative methodology is applied, through the phenomenological method. The technique used to collect the information is the discussion group, and a content analysis is carried out on it. The software Atlas.ti 8.0 is used as a support resource for the analysis.ResultsHealth professionals highlight group work as a means of achieving change, and point to the importance of intervention as a non-medicalizing strategy. They perceive that the participants obtain some benefits: the improvement of their personal well-being, the increase of their self-esteem and self-determination, and the generation of social networks, benefits that also affect their immediate surroundings.ConclusionsIn the opinion of the professionals, the strategy has positive effects on women and does not mean an increase in resources for the health system. In addition, they express the importance of provide women with tools to cope with daily life problems derivates mostly from gender mandates of a patriarchal society. 相似文献
97.
98.
Joseane C. de Castro Laila V. de Almeida Mariana Santos Cardoso Fabricio M. Silva Oliveira Denise S. Nogueira João Luis Reis-Cunha Luisa M.D. Magalhaes Bin Zhan Maria Elena Bottazzi Peter J. Hotez Lilian L. Bueno Daniella Castanheira Bartholomeu Ricardo T. Fujiwara 《Vaccine》2021,39(2):394-401
An estimated 400 million people are infected by parasites of the genus Ascaris and the existing control measures are inefficient. Vaccine development using B cell antigens is a promising strategy for increased protection against this parasite. The present study aimed at developing a chimeric protein capable of conferring protection against infection by Ascaris sp. For this purpose, we performed B-cell epitope predictions on previously described vaccine candidate proteins from Ascaris suum and the corresponding peptides were used to construct a chimeric protein. Female BALB / c mice were immunized subcutaneously in three doses at 10 day intervals with a vaccine formulation comprised of the chimeric protein together with monophosphoryl lipid A (MPLA). Control groups included protein alone, MPLA, or PBS. After challenge infection, animals vaccinated with chimeric protein plus MPLA showed a reduction of 73.54% of larval load in the lung compared to control group animals. Animals immunized with chimeric protein plus MPLA also display higher IgG response and a reduction in lung inflammation. Our study highlights how chimeric proteins containing more than one B cell epitope can enhance immune protection against helminthic infection and offer new approaches to the development of Ascaris vaccines. 相似文献
99.
Maria Rosaria Gualano Alessio Corradi Gianluca Voglino Dario Catozzi Elena Olivero Michele Corezzi Fabrizio Bert Roberta Siliquini 《Vaccine》2021,39(6):901-914
Influenza is a disease responsible for thousands of deaths every year. Although healthcare workers (HCWs) represent a way of contagion for patients, vaccination coverage among them is low. Mandatory vaccination has been proposed, but controversies remain. This systematic review and meta-analysis aimed to assess the acceptance of mandatory vaccination by HCWs, and to investigate associated characteristics. MEDLINE, Scopus, Embase, PsycInfo, CINAHL and Web of Science were used to search for studies assessing the topic. PRISMA statements were followed. Of the 13,457 univocal records found, 52 studies were included in the systematic review and 40 in the meta-analysis. The pooled proportion of HCWs accepting the policy was of 61% (95% CI: 53%- 68%) but with great heterogeneity between continents (from 54% in Europe to 69% in Asia) and in different professionals (from 40% in nurses to 80% in students). Vaccinated HCWs agreed more frequently with mandatory vaccination than non-vaccinated ones. More studies that consider mandatory vaccination acceptance as the main outcome are needed, but the results of this study confirm that in some settings the majority of HCWs favour mandatory vaccination. This, combined with effects that a flu epidemic could have if overlapped to pandemics with similar symptoms, requires renewed considerations on mandatory vaccination. 相似文献
100.
Pablo Lapunzina Jos Ignacio Rodríguez Elena de Matteo Ricardo Gracia Felipe Moreno 《American journal of medical genetics. Part A》1995,55(3):349-355
We report on 3 patients with Mulibrey nanism (MN), or Perheentupa syndrome: the first 2 sibs from Argentina and a new patient from Spain. All 3 patients had growth failure, short stature, abnormal pigmentary retinal changes, and a J-shaped sella turcica. These findings are considered major criteria of MN. Two had pericardial constriction, which is a frequent and lifethreatening abnormality in this syndrome. MN is a rare autosomal recessive condition. Reviewing the 39 patients described so far, we have classified the anomalies into the very frequent (present in more than 66%), frequent (in at least 25%), and not frequent. Identifying the anomalies specific to MN should help its early diagnosis and treatment. © 1995 Wiley-Liss, Inc. 相似文献