应用OHIP-14评价2种种植系统OHRQoL的差异

目的 研究2种种植系统修复治疗后口腔健康相关生活质量（OHRQoL）的差异,为临床种植系统的选择和治疗效果的评估提供参考。方法 临床收集门诊且符合纳入标准的种植义齿修复患者100例,其中50例A组行安多健（Anthogry）种植系统修复,50例B组行士卓曼（Straumann）种植系统修复。采用口腔健康影响程度量表（OHIP-14）中文版作为测量方法研究2种种植系统修复6个月后患者OHRQoL的得分情况,比较两种种植系统修复后患者的OHRQoL的差异。结果 A组："生理性疼痛"得分最高（P₅₀=3.00）,其次为"心理不适,心理障碍"（P₅₀=2.00）;"吃什么东西都不舒服"最常给牙列缺损患者带来负面影响。B组："生理性疼痛"、"心理不适"、"生理障碍"三者得分最高（P₅₀=2.00）,其次为"心理障碍"（P₅₀=1.5）;"对自己的饮食很不满意"最常给牙列缺损患者带来负面影响。治疗后Anthogry与Straumann量表总得分差异无统计学意义（P>0.05）。结论 2种种植系统均能改善患者口腔健康状况,患者对两种系统的整体主观感受并无明显差异。     

补肺健脾益肾方治疗对老年COPD稳定期患者T淋巴细胞亚群、BODE指数及生活质量的影响

目的:评价补肺健脾益肾方治疗老年慢性阻塞性肺疾病(COPD)稳定期的疗效及对患者外周血T淋巴细胞亚群、BODE指数及生活质量的影响.方法:将80例中医辨证为肺脾肾气虚型COPD稳定期患者随机分组,对照组(40例)仅采取常规西医治疗,而观察组(40例)在常规西医治疗的基础上联合补肺健脾益肾汤,治疗8周后比较临床疗效及患者外周血T淋巴细胞亚群、BODE指数及生活质量的变化.结果:经治疗后观察组BODE指数及BMI积分、FEV1积分、MMRC积分、6MWT积分均较对照组明显减少,差异具有统计学意义(P＜0.05);经治疗后观察组CD3+、CD4+及CD4+/CD8+较对照组明显升高,CD8 +水平较对照组明显降低,差异具有统计学意义(P＜0.05);两组经治疗后肺功能指标FEV1和FEV1/FVC均较治疗前有明显改善,差异具有统计学意义(P＜0.05);两组治疗后SGRQ评分均较治疗前明显降低,但观察组治疗后SGRQ评分明显低于对照组,差异具有统计学意义(P＜0.05).结论:补肺健脾益肾方用于老年COPD稳定期治疗可改善患者肺功能及BODE指数,提高生活质量,增强细胞免疫功能.     

Toxic effect of puromycin on erythrocyte membranes which is unrelated to inhibition of protein synthesis

Exposure of rabbit or human erythrocytes to concentrations of puromycin as low as 7 x 10(-4)M for 2 hr causes damage to the cell membrane, as evidenced by increased susceptibility of the cells to hyposmotic lysis, increased cell rigidity, and ultrastructural changes consistent with severe membrane damage. Puromycin causes a concentration-dependent internalization of the erythrocyte membrane, resulting in vacuolization of the cells, at concentrations between 7 x 10(-4) M and 10(-2) M. Since the erythrocyte does not synthesize protein, the data indicate that puromycin has a direct toxic effect on erythroid cell membranes which is unrelated to its action in inhibiting the synthesis of protein.     

唇腭裂患者AF-BF距及AXB角的测量分析

目的 研究唇腭裂患者AF-BF距和AXB角.方法 选取20例替牙期及30例恒牙期唇腭裂患者拍摄头颅定位侧位X线片,测量其AF-BF距及AXB角与北京市同龄、同性别正常儿童、青少年的AF-BF距及AXB角值进行比较.结果 替牙期和恒牙期唇腭裂患者AF-BF距及AXB角值无性别差异(P > 0.05).新疆地区替牙期和恒牙期唇腭裂患者AF-BF距小于北京市正常儿童、青少年(P < 0.05),而AXB角值差异无统计学意义(P > 0.05).结论 AF-BF距可以作为评价唇腭裂患者上下颌骨间矢状关系的指标之一,但最好进行综合分析.     

不育患者精索静脉曲张手术前后精液质量变化的观察

目的:观察不育患者精索静脉曲张手术前后精液质量的变化,探讨手术的价值。方法:按WHO标准常规分析110例不育伴精索静脉曲张患者手术前后的精液质量。结果:110例精索静脉曲张患者术后精子密度、(A+B)级精子比率、有效精子数、精子活动率、活动精子数、精子低渗肿胀比率、正常形态精子比率较术前明显提高,两组差别有显著性意义(P0.05)。结论:精索静脉曲张手术能改善精液的质量。     

浅谈分子筛制氧系统的选择使用和管理

本文论述了分子筛制氧机的工作原理、主要组成部分及作用.强调了应严格遵守规章制度,认真做好制氧机的维护保养,加强质量监控和管理.同时阐述了医院在选购制氧系统时要综合分析影响其能耗的因素,在保证氧气产量和纯度的前提下,尽量降低系统能耗,提高长期运行的经济效益.     

Early and late components of error monitoring in violent offenders with psychopathy

BACKGROUND: One of the most recognizable features of psychopathy is the reduced ability to successfully learn and adapt overt behavior. This might be due to deficient processing of error information indicating the need to adapt controlled behavior. METHODS: Event-related potentials (ERPs) and behavioral components of error-monitoring processes were investigated in 16 individuals with psychopathy and in 18 healthy subjects. A letter version of the Eriksen flanker task was used in two conditions. The first condition (normal condition) required participants to press one of two buttons depending on the identity of the target stimulus. The second condition (signaling condition) required them to signal each time they had committed an error by making a second press on a signaling button. Early stages of error monitoring were investigated by using the error-related negativity (ERN/Ne) and post-error slowing as indexes. Later stages were explored by examining the error positivity (Pe) and signaling rates. RESULTS: Both groups showed similar ERN amplitudes and amounts of post-error slowing. The psychopathic group exhibited both reduced Pe amplitudes and diminished error-signaling rates compared with the control group. CONCLUSIONS: Individuals with psychopathy show intact early error processing and automatic behavioral adaptation but have deficits in later stages of error processing and controlled behavioral adaptation. This is an indication that individuals with psychopathy are unable to effectively use error information to change their behavior adequately.     

Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers

Hyperinsulinaemia/euglycaemia therapy (HIET) consists of the infusion of high-dose regular insulin (usually 0.5 to 1 IU/kg per hour) combined with glucose to maintain euglycaemia. HIET has been proposed as an adjunctive approach in the management of overdose of calcium-channel blockers (CCBs). Indeed, experimental data and clinical experience, although limited, suggest that it could be superior to conventional pharmacological treatments including calcium salts, adrenaline (epinephrine) or glucagon. This paper reviews the patho-physiological principles underlying HIET. Insulin administration seems to allow the switch of the cell metabolism from fatty acids to carbohydrates that is required in stress conditions, especially in the myocardium and vascular smooth muscle, resulting in an improvement in cardiac contractility and restored peripheral resistances. Studies in experimental verapamil poisoning in dogs have shown that HIET significantly improves metabolism, haemodynamics and survival in comparison with conventional therapies. Clinical experience currently consists only of a few isolated cases or short series in which the administration of HIET substantially improved cardiovascular conditions in life-threatening CCB poisonings, allowing the progressive discontinuation of vasoactive agents. While we await further well-designed clinical trials, some rational recommendations are made about the use of HIET in severe CBB overdose. Although the mechanism of action is less well understood in this condition, some experimental data suggesting a potential benefit of HIET in β-adrenergic blocker toxicity are discussed; clinical data are currently lacking.     

Epidemiology of pityriasis versicolor in Adana, Turkey

Pityriasis versicolor is a common superficial mycoses of the skin. It is now recognized that the causative organisms of this infection are different species of Malassezia . The aim of this study was to determine the distribution of Malassezia species in patients with pityriasis versicolor in Adana, Turkey. In total, 97 patients positive for Malassezia elements, namely, yeast cells and short hyphae in microscopic examination, were included in the study. All samples were inoculated in plates containing modified Dixon's medium. However, only 44 of the patients (45.4%) showed Malassezia spp. in culture. Malassezia globosa (47.7%) was the most commonly isolated species followed by Malassezia furfur (36.4%) and Malassezia slooffiae (15.9%). Mixed Malassezia species were not isolated. In conclusion, M. globosa was found to be the predominant PV isolate in Adana, Turkey.     

Glutaric aciduria and suspected child abuse

AIM—To determine the relation between respiratory function in infancy and at school age in children who have undergone oesophageal atresia and tracheoesophageal fistula repair, and assess the value of infant respiratory function testing; and to examine the effect of bronchodilators.METHOD—Fourteen children (6 girls, and 8 boys) who had undergone respiratory function testing in infancy were retested at school age (7?12 years). Measurements included lung volume, airways resistance, peak flow, and spirometry. Clinical problems were investigated by questionnaire. Twelve children had repeat measurements after taking salbutamol.RESULTS—Predominant complaints were non-productive cough and dysphagia, but even those children with major problems in infancy reported few restrictions at school or in sport or social activities. Respiratory function and clinical findings at school age appeared unrelated to status in infancy, such that even the patients with severe tracheomalacia requiring aortopexy did not have lung function testing suggestive of malacia at school age. Most patients showed a restrictive pattern of lung volume which would appear to result from reduced lung growth after surgery rather than being a concomitant feature of the primary congenital abnormality. Although six children reported wheeze and four had a diagnosis of asthma, only one responded to salbutamol. This suggests that a tendency to attribute all lower respiratory symptoms to asthma may have led to an overdiagnosis of this condition in this patient group.CONCLUSION—Respiratory function testing in infancy is of limited value in medium term prognosis, but may aid management of contemporary clinical signs. In children respiratory function testing is valuable in assessing suspected asthma and effects of bronchodilators.