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101.
Dulgeroglu Deniz Umay Ebru Bal Ajda Tetik Menevse Gulsum Tatlican Semih Cakci Aytul 《Rheumatology international》2012,32(1):241-244
Tumor necrosis factor-alpha (TNF-α) antagonists are employed increasingly during recent years in patients with active rheumatoid
arthritis who do not respond to disease-modifying anti-rheumatic drugs. Contraindications such as infections, auto-antibody
formation and hypersensitive reactions can be observed during the treatment with TNF-α antagonist drugs. Our case was a 52-year-old
woman, followed by several centers for a period of 21 years with a seropositive, erosive and nodular RA diagnosis. Anti TNF-α
treatment was commenced due to the failure to control the disease. During the treatment, a serious cellulite developed, which
required hospitalization and surgical debridement as well as intravenous antibiotics treatment. Through the present case,
we aimed to draw attention to the skin infection during the use of etanercept in a patient with RA. 相似文献
102.
Deniz O Aygül R Kotan D Ozdemir G Odabaş FO Kaya MD Ulvi H 《Rheumatology international》2012,32(5):1285-1290
The aim of this study was to evaluate the efficacy of steroid injection for the treatment of the carpal tunnel syndrome (CTS),
with F-wave parameters and sympathetic skin response (SSR). Seventeen hands of 10 women patients were treated with local steroid
injection with 2-month follow-up. All patients underwent single injection into the carpal tunnel. Response to injection was
measured nerve conduction studies (NCSs), median nerve F waves, and SSR before and after treatment. To determine the normal
values, 42 hands of 21 healthy women were also studied. There was a significant improvement of sensory and motor nerve conduction
values when compared to baseline values (P < 0.01). At the end of follow-up period, the median sensory distal latency and the sensory latency differences between the
median and the ulnar nerve were improved 35 and 65%, respectively. The maximum, mean F-wave amplitudes and chronodispersion
showed a slight improvement with respect to baseline values and controls, but statistical significance was not achieved after
treatment. Although no statistically significant improvements were observed in SSR parameters, slightly decreased amplitudes
and increased habituation of SSR were noted at the end of the treatment. The present study shows that the local steroid injection
results in improvement in NCSs values, but the F-wave parameters were not effectual in short-term outcome of CTS treatment.
These findings suggest that the sensory latency differences between the median and the ulnar wrist-to-digit 4 are better parameters
in the median nerve recovery after treatment than the median sensory distal latency. Furthermore, the SSR does not seem to
be a sensitive method in follow-up of CTS treatment. 相似文献
103.
104.
Thalassemia is one of the most common hereditary disorders in the Mediterranean region. We report here the results of a premarital screening carried out in Ad?yaman in the southeastern region of Turkey, a region with a hitherto unknown incidence of β-thalassemia (β-thal). In order to detect β-thal carrier frequency and genotypes of carriers from the city of Ad?yaman, Turkey, both high performance liquid chromatography (HPLC) and the red blood cell counts of 1616 people who applied for premarital tests were analyzed. Blood cell counts were measured by a cell counter and the hemoglobin (Hb) fractionation was carried out by HPLC. The frequency of β-thal carriers in the city of Ad?yaman was 1.91% and the frequency of abnormal Hbs was 0.07%. We report 28 chromosomes of β-thal traits with 10 different mutations, including the first report of codon 17 (AAG>TAG) in Turkey and one individual who was heterozygous for Hb D-Los Angeles [β121(GH4)Glu→Gln, GAA>CAA]. This study was the first to be performed on the frequency and molecular pathology of β-thal mutations in Ad?yaman in the southeastern region of Turkey. We report that the prevalence of the thalassemia trait is similar in all regions of our country, but the prevalence of mutation heterogeneity varies from region to region. 相似文献
105.
106.
Cevik A Kula S Olgunturk R Tunaoglu FS Oguz AD Pektas A Saylan B 《Echocardiography (Mount Kisco, N.Y.)》2012,29(7):840-848
Introduction and Objective: The present study aims to quantitatively evaluate the right ventricle (RV) function by means of transthoracic echocardiography in normal children and childhood congenital heart disease patients with pulmonary hypertension. Patients and Methods: This study was conducted in a cohort including 40 healthy children and 30 pediatric patients with pulmonary hypertension who were diagnosed under close surveillance at the study center between October 2009 and November 2010. Results: Statistically significant differences were found between the patient and control groups for the right ventricle myocardial performance index (RVMPI), the left ventricle myocardial performance index (LVMPI), the tricuspid valve systolic flow velocity (Ts), the ratio of systolic pulmonary artery pressure to the right ventricle outflow tract systolic flow velocity time integral (sPAP/RVOT VTI), and the ratio of systolic pulmonary artery pressure to right ventricle outflow tract systolic flow velocity time integral × heart rate (sPAP/[RVOT VTI×HR]). When the children were divided into three groups based on their pulmonary vascular resistance significant differences emerged that predicted an increasing severity of RV dysfunction. Significant differences were also observed for the RVMPI, the LVMPI, and the Ts as well as for echocardiographic pulmonary flow (Qp) and systemic flow (Qs). Discussion: The present study demonstrates that echocardiographic parameters can be used for the quantitative detection of RV dysfunction in childhood congenital heart disease patients with high pulmonary artery pressure (systolic, diastolic, and mean) or pulmonary vascular resistance. 相似文献
107.
Michael Castro M.D. Deniz Aslan M.D. J. Carlos Manivel M.D. Stefan E. Pambuccian M.D. 《Diagnostic cytopathology》2013,41(1):85-91
Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine‐needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66‐year‐old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patient's prior pathology specimen and of the Papanicolaou‐stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led to the correct diagnosis, which was supported by immunoperoxidase stains (cytokeratin AE1/AE3+, S100+, GFAP?). A review of the literature found no previous instances in which chordomas mimicked pleomorphic adenoma on FNA. However, since the two tumors show significant cytomorphologic overlap, including the presence of abundant fibrillary matrix with embedded neoplastic cells and single bland spindle and epithelioid tumor cells with occasional intranuclear pseudoinclusions, we compared their cytologic features. A review of the FNA cytologic features of this case of chordoma and of 17 consecutive cases of pleomorphic adenoma found that the presence of a more abundant, focally vacuolated cytoplasm favors chordoma over pleomorphic adenoma. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc. 相似文献
108.
The aim of the study was to determine the association between birthweight, maternal medical history and acne, hirsutism, and menstrual disorder symptoms in Turkish adolescent population. Self-administered questionnaires were distributed to all volunteer female students at 15 secondary schools. The subjects' body mass index, birthweight, age at menarche, pattern of menstrual cycle, and presence of acne or hirsutism problems were recorded. Maternal obstetric parameters, menstrual cycle, presence of acne or hirsutism at present and at adolescent period were also asked. The impact of birthweight and maternal history on acne, hirsutism, and menstrual disorder symptoms was evaluated. The results of the study showed that after exclusion of subjects born prematurely, total of 1,309 students filled the questionnaires properly and included in the study. Of these students, 174 had low birthweight (LBW) (<2,500?g), 925 had appropriate (2,500-4,000?g), and 210 had high birthweight (>4,000?g). LBW students had higher incidence of menstrual disorder and acne problems (P?=?0.032 and P?=?0.011, respectively). Maternal acne and hirsutism problems were significantly often in LBW group. Multivariate analysis showed that LBW was a predictor of acne, hirsutism, and menstrual disorder at adolescent period (P?=?0.001; P?=?0.01, and 0.02, respectively). In addition, maternal menstrual disorder was also a predictor of menstrual disorder (P?=?0.035). We concluded that LBW is a good predictor of acne, hirsutism, and menstrual disorder problems in Turkish adolescent population. 相似文献
109.
The risk of venous thromboembolism (VTE) increases in the presence of plasma cell dyscrasias. Monoclonal gammopathy of undetermined
significance (MGUS) and multiple myeloma (MM) share an intrinsic increased risk of VTE. Treatment with thalidomide and lenalidomide
further increases the incidence of VTE in certain MM patient subsets. The pathogenesis remains unclear, but probably involves
several factors such as activation of procoagulant factors, acquired activated protein C resistance, and inflammation. In
addition to general risk factors for VTE, such as older age, immobility, surgery, and inherited thrombophilia, there are some
MM-specific and treatment-related factors that contribute to the increased risk. The risk for VTE is high under treatment
with thalidomide or lenalidomide in combination with dexamethasone or multi-agent chemotherapy. We report 3 cases of MM with
VTE with review of the literature. This review highlights the risk factors for VTE in MM and general, disease-specific and
treatment-related mechanisms for thrombosis. 相似文献
110.