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991.
Camilla Barbero Mazzucca Davide Raineri Giuseppe Cappellano Annalisa Chiocchetti 《Nutrients》2021,13(11)
Nutrition and immunity are closely related, and the immune system is composed of the most highly energy-consuming cells in the body. Much of the immune system is located within the GI tract, since it must deal with the huge antigenic load introduced with food. Moreover, the incidence of immune-mediated diseases is elevated in Westernized countries, where “transition nutrition” prevails, owing to the shift from traditional dietary patterns towards Westernized patterns. This ecological correlation has fostered increasing attempts to find evidence to support nutritional interventions aimed at managing and reducing the risk of immune-mediated diseases. Recent studies have described the impacts of single nutrients on markers of immune function, but the knowledge currently available is not sufficient to demonstrate the impact of specific dietary patterns on immune-mediated clinical disease endpoints. If nutritional scientists are to conduct quality research, one of many challenges facing them, in studying the complex interactions between the immune system and diet, is to develop improved tools for investigating eating habits in the context of immunomediated diseases. 相似文献
992.
Niko Fioravanti Luca Pierantoni Davide Mencarelli Claudio Turchetti Shino Hamao Hideki Okamoto Hidenori Goto Ritsuko Eguchi Akihiko Fujiwara Yoshihiro Kubozono 《RSC advances》2021,11(13):7538
Organic field-effect transistors (FETs) can be applied to radio-frequency identification tags (RFIDs) and active-matrix flat-panel displays. For RFID application, a cardinal functional block is a ring oscillator using an odd number of inverters to convert DC voltage to AC. Herein, we report the properties of two ring oscillators, one formed with [6]phenacene for a p-channel FET and N,N′-dioctyl-3,4,9,10-perylenedicarboximide (PTCDI-C8) for an n-channel FET, and one formed with 3,10-ditetradecylpicene ((C14H29)2-picene) for a p-channel FET and PTCDI-C8 for an n-channel FET. The former ring oscillator provided a maximum oscillation frequency, fosc of 26 Hz, and the latter a maximum fosc of 21 Hz. The drain–drain voltage, VDD, applied to these ring oscillators was 100 V. This may be the first step towards a future practical ring oscillator using phenacene molecules. The values of field-effect mobility, μ in the p-channel [6]phenacene FET and n-channel PTCDI-C8 FET, which form the building blocks in the ring oscillator with an fosc value of 26 Hz, are 1.19 and 1.50 × 10−1 cm2 V−1 s−1, respectively, while the values in the p-channel (C14H29)2-picene FET and n-channel PTCDI-C8 FET, which form the ring oscillator with an fosc of 21 Hz, are 1.85 and 1.54 × 10−1 cm2 V−1 s−1, respectively. The μ values in the p-channel FETs are higher by one order of magnitude than those of the n-channel FET, which must be addressed to increase the value of fosc. Finally, we fabricated a ring oscillator with ZrO2 instead of parylene for the gate dielectric, which provided the low-voltage operation of the ring oscillator, in which [6]phenacene and PTCDI-C8 thin-film FETs were employed. The value of fosc obtained in the ring oscillator was 24 Hz. In this ring oscillator, the VDD value applied was limited to 20 V. The durability of the ring oscillators was also investigated, and the bias stress effect on the fosc and the amplitude of the output voltage, Vout are discussed. This successful operation of ring oscillators represents an important step towards the realization of future practical integrated logic gate circuits using phenacene molecules.A ring oscillator consisting of p-channel and n-channel organic FETs. 相似文献
993.
The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. 相似文献
994.
Linda Calistri Vieri Rastrelli Cosimo Nardi Davide Maraghelli Sofia Vidali Michele Pietragalla Stefano Colagrande 《World journal of gastroenterology : WJG》2021,27(46):7866-7893
The liver is the major drug-metabolizing and drug-detoxifying organ. Many drugs can cause liver damage through various mechanisms; however, the liver response to injury includes a relatively narrow spectrum of alterations that, regardless of the cause, are represented by phlogosis, oxidative stress and necrosis. The combination of these alterations mainly results in three radiological findings: vascular alterations, structural changes and metabolic function reduction. Chemotherapy has changed in recent decades in terms of the drugs, protocols and duration, allowing patients a longer life expectancy. As a consequence, we are currently observing an increase in chemotherapy-associated liver injury patterns once considered unusual. Recognizing this form of damage in an early stage is crucial for reconsidering the therapy regimen and thus avoiding severe complications. In this frontier article, we analyze the role of imaging in detecting some of these pathological patterns, such as pseudocirrhosis, “yellow liver” due to chemotherapy-associated steatosis-steatohepatitis, and “blue liver”, including sinusoidal obstruction syndrome, veno-occlusive disease and peliosis. 相似文献
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998.
Fortunato Lombardo Stefano Passanisi Davide Tinti Maria Francesca Messina Giuseppina Salzano Ivana Rabbone 《Journal of diabetes science and technology》2021,15(6):1377
Introduction:Despite advances in the management of type 1 diabetes (T1D), there is an increasing incidence of skin reactions related to diabetes devices such as patch pumps and glucose sensors. Aim of the present study was to assess the prevalence of dermatological complications in pediatric patients with T1D using technological devices.Methods:Online survey regarding skin reactions related to the use of patch pumps and/or glucose sensors was administered to families of children and adolescents (0-17 years) with T1D. Data were collected on demographic characteristics, duration of diabetes, and clinical features of dermatological complications if present.Results:Our study population consisted of 139 patients (female 51.8%) aged 11.1 ± 3.3 years. More than half (51.1%) experienced skin reactions due to patch pumps or glucose sensors. Dermatological complications were mainly caused by continuous glucose monitoring (56.3% of total). Timing of appearance of dermatological reactions varied from a few days to several months after the introduction of the device. The application of hypoallergenic barrier bandages was the most frequently adopted measure to solve the issue.Conclusions:Our study confirmed high frequency of dermatological complications among pediatric patients with type 1 diabetes. Well-designed studies are awaited to provide clear recommendations to minimize the burden of skin issues related to technological devices. 相似文献
999.
Martina Setti Marco Merlo Marta Gigli Laura Munaretto Alessia Paldino Davide Stolfo Carola Pio Loco Kristen Medo Caterina Gregorio Antonio De Luca Sharon Graw Matteo Castrichini Antonio Cannatà Flavio Luciano Ribichini Matteo Dal Ferro Matthew Taylor Gianfranco Sinagra Luisa Mestroni 《European journal of heart failure》2024,26(3):581-589
1000.
Hemoglobin adducts of benzo[a]pyrene diolepoxide in newspaper vendors: association with traffic exhaust 总被引:1,自引:0,他引:1
Pastorelli Roberta; Restano Jolanda; Guanci Marco; Maramonte Monica; Magagnotti Cinzia; Allevi Riccardo; Lauri Davide; Fanelli Roberto; Airoldi Luisa 《Carcinogenesis》1996,17(11):2389-2394
Benzo[a]pyrene diol epoxide adducts with hemoglobin (Hb) weremeasured to detect human exposure to environmental benzo[a]pyrenefrom traffic exhaust. Benzo[a]pyrene tetrahydrotetrols (BPTs)released from Hb after acid hydrolysis were quantitated by gaschromatography-mass spectrometry after immunoaffinity chromatography.Fifty three newspaper vendors were enrolled. The median adductconcentration was 0.3 fmol BPTs/mg Hb in high density traffic-exposedvendors and 相似文献