1962名男性新兵人格诊断问卷(PDQ-4~+)结果分析

目的了解部队新兵人格倾向特征。方法采用人格诊断问卷(PDQ-4+)对某部队1 962名男性新兵进行抽样调查,并与大学生样本进行比较。结果 (1)除表演型、反社会型分量表外,新兵其他各分量表及总量表得分均显著低于大学生(P<0.05);新兵人格倾向亚型的阳性检出率在7.25%~36.07%。(2)低年龄组新兵在偏执型、分裂型、自恋型、边缘型、反社会型、依赖型分量表及总量表的得分均高于高年龄组新兵(P<0.05);父母关系和睦的新兵各个人格倾向亚型(除强迫型外)得分均显著低于父母关系不和睦新兵的得分(P<0.05);农村与城市新兵的偏执型、分裂型、表演型、自恋型、边缘型、反社会型和被动攻击型分量表得分,差异有统计学意义(P<0.05),且城市新兵人格障碍得分更高(P<0.05);除分裂样型、自恋型、强迫型分量表外,独生子女新兵其他分量表及总量得分均高于非独生子女新兵(P<0.05)。结论新兵的人格倾向问题好于大学生样本,低龄、父母关系不和睦、居住在城市和独生子女新兵有更多的人格倾向问题。     

Non-invasive Assessment of Changes in Muscle Injury by Ultrasound Shear Wave Elastography: An Experimental Study in Contusion Model

The present study investigated the potential of ultrasound shear wave elastography (SWE) in assessment of muscle stiffness in muscle injury. SWE was performed on the injured muscle in 30 New Zealand rabbits that were randomly assigned to three groups: the contusion group, which was not treated with an efficient therapeutic strategy after muscle injury; the treatment group, which was treated with a therapeutic scheme after muscle injury; and the healthy group, which was not injured and served as a control. Both the mean Young's modulus (E_mean) and the maximum Young's modulus (E_max) were obtained pre-injury and 0.5, 1, 3, 5, 7, 14 and 28 d post-injury. At these time points, a rabbit in each group was randomly selected for biopsy for histopathological observation as well as comparison with Young's modulus. Eventually, all muscle tissues were collected for histologic analysis of collagen fiber formation. The contusion group had the highest Young's modulus, followed by the treatment group and then the healthy group (p < 0.05). In both the contusion and treatment groups, E_mean and E_max gradually increased within 1–3 d after injury, followed by a gradual decrease. Compared with the healthy group, histopathologic analysis of the contusion and treatment groups revealed the myofibril destruction process, inflammatory reaction and myofibril regeneration. The amount of collagen fibers in the contusion group was maximal compared with the treated and healthy groups (p?=?0.001 and p < 0.001, respectively). There were more collagen fibers in the treatment group than in the healthy group (p?=?0.003). The abundance of collagen fibers was positively correlated with the value of Young's modulus (E_mean: r?=?0.706, p < 0.001; E_max: r?=?0.761, p < 0.001). Thus, SWE can be used to detect pathologic changes in injured muscle and to monitor therapeutic effects.     

静脉麻醉药对脂多糖诱导的神经星形胶质细胞增殖的影响及其机制

目的 检测静脉麻醉药对脂多糖诱导的神经星形胶质细胞的影响及其机制。 方法 利用MTT实验、集落形成实验和Annexin V-FITC/PI双染色法检测静脉麻醉药对脂多糖作用后的神经星形胶质细胞增殖和凋亡的影响。Western blotting技术检测相关机制。 结果 静脉麻醉药可以逆转脂多糖诱导的神经星形胶质细胞增殖。经麻醉药处理后的神经星形胶质细胞p-Akt和p-mTOR蛋白表达下降，Caspase-3和Caspase-9表达水平升高。结论 静脉麻醉药可以通过抑制mTOR通路逆转脂多糖诱导的神经星形胶质细胞增殖。