Evaluation of the quality of HLA antibodies in placental blood

Two groups of blood samples, placental blood and female donor blood, were shown to have a frequency of 16.4 and 1.5% of anti-human leucocyte antigen (HLA) antibodies respectively. The specificities and qualities of these antibodies were further characterized by their relative coefficient (r) values and strength indices (SIs). Most had an r value of approximately one, but their SIs varied from 41 to 100%. Among these two groups, nine samples gave very strong and definite results (r = 1 and SI = 100%). Data analysis revealed that the qualities of the two groups were comparable. However, the antibody positive rate was higher in placental blood samples than that in donor blood samples.     

雄激素非依赖性前列腺癌发生的机制

转移性前列腺癌依然是潜在的致死性肿瘤。虽然雄激素剥夺性治疗（androgen deprivation therapy,ADT）至今仍被认为是前列腺癌最为有效的治疗手段,但大多数患者会最终发展成激素非依赖性前列腺癌而死亡。众所周知,引起雄激素受体（andro-gen-independent,AR）活化的机制在激素非依赖性前列腺癌发生过程中发挥着十分重要的作用。最新研究表明,癌干细胞（canc-er stem cells,CSC）或癌细胞的上皮-间质转化（epithelial-to-mesenchymal transition,EMT）也会促进激素非依赖性前列腺癌的进展。鉴于前列腺癌向激素非依赖性发展途径的多样性,可以想象,在改善患者生存方面取得的真正进展必将依赖于针对各种雄激素非依赖性进展途径的联合治疗。因此,本文就前列腺癌向激素非依赖性进展的相关潜在机制作一综述。     

EXTENSIVE PULMONARY TUBERCULOUS INFILTRATION WITH COMPLETE RESOLU TION

Since the epituberculous type of pulmonary tuberculosis was first reported from this hospital in 1930 (1), an attempt has been made to examme cases of extensive pulmonary tuberculous infiltration at fre- quent intervals particularly with regard to the general state of nutri- tion, physical findings in the chest and roentgenoIogical changes of the pulmonary lesion. Altogether about twenty cases were encountered. Some of them were impossible to follow on account of change of address. In eight cases there had been a complete resolution of the infiltration in a period of about one and one-half to seven and one-half '' years. In view of the scarcity of reports of prolonged follow-up studies in the literature, the histories of these eight patients are here- with presented. Those of the two patients with fatal termination and that of one patient with a partially resolved infiltration were appended for the sake of comparison and discussion. The important findings in . the eight cases with complete resolution are summar,zed in Table l.     

HEPATITIS FOLLOWING SULFANILAMIDE THERAPY CASE REPORT . WAN-NIEN BIF.N, M.D. AND CHEN.LANG TUNG. M.D. Department of Medicine, Peiping Unzon Medical College, Peiping, China

In the reviews of the literature on sulfanilamide and its related compounds by Tyson (1), Holman and Duff (2) and Keefer (3) the toxic manifestations cited are: cyanosis due to sulphemoglobinemia or metahemogIobinemia; anemia either of the aplastic or of the hemolytic type; agranulocytosis; skin lesions such as eczema, generalized maculo- papular and morbilliform rash, urticaria, exfoliative dermatitis, toxic erythema, and purpuric rash; acidosis; pyrexia; anorexia; headache; vertigo; malaise; diarrhea; cardiac irregularity; optic neuritis; and circuIatory collapse. No mention was made of hepatitis. However, Rimington found increased porphyrinuria in nearly every case of hemolytic streptococcic infections treated with sulfanilamide, who did not clevelop hemolytic anemia, and in every white rat given the drug experimentally (mainly corproporphyrine HI with a trace of corpro- porphyrine Iin the urine) (4). Silver and Elliot found porphyrine in the urine of three patients treated with sulfanilamide who developed skin rash (5). As increased excretion of porphyrine is often observed in patients with liver damage (6), these findings may mean that in every patient treatecl with suIfanilamide the liver is affected whether clinical hepatitis manifests itself or not.