全文获取类型
收费全文 | 1170篇 |
免费 | 85篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 73篇 |
妇产科学 | 15篇 |
基础医学 | 149篇 |
口腔科学 | 20篇 |
临床医学 | 250篇 |
内科学 | 240篇 |
皮肤病学 | 83篇 |
神经病学 | 81篇 |
特种医学 | 76篇 |
外科学 | 109篇 |
综合类 | 67篇 |
预防医学 | 45篇 |
眼科学 | 8篇 |
药学 | 90篇 |
中国医学 | 3篇 |
肿瘤学 | 36篇 |
出版年
2021年 | 11篇 |
2020年 | 15篇 |
2019年 | 12篇 |
2018年 | 11篇 |
2017年 | 13篇 |
2016年 | 14篇 |
2015年 | 15篇 |
2014年 | 36篇 |
2013年 | 41篇 |
2012年 | 25篇 |
2011年 | 29篇 |
2010年 | 49篇 |
2009年 | 28篇 |
2008年 | 27篇 |
2007年 | 68篇 |
2006年 | 30篇 |
2005年 | 29篇 |
2004年 | 20篇 |
2003年 | 20篇 |
2002年 | 18篇 |
2001年 | 23篇 |
2000年 | 17篇 |
1999年 | 21篇 |
1998年 | 35篇 |
1997年 | 51篇 |
1996年 | 35篇 |
1995年 | 41篇 |
1994年 | 39篇 |
1993年 | 29篇 |
1992年 | 29篇 |
1991年 | 13篇 |
1990年 | 31篇 |
1989年 | 37篇 |
1988年 | 30篇 |
1987年 | 22篇 |
1986年 | 16篇 |
1985年 | 19篇 |
1984年 | 11篇 |
1983年 | 17篇 |
1982年 | 11篇 |
1981年 | 14篇 |
1979年 | 9篇 |
1977年 | 11篇 |
1976年 | 14篇 |
1974年 | 9篇 |
1968年 | 10篇 |
1966年 | 11篇 |
1965年 | 13篇 |
1963年 | 12篇 |
1959年 | 13篇 |
排序方式: 共有1347条查询结果,搜索用时 255 毫秒
111.
Coghill D Soutullo C d'Aubuisson C Preuss U Lindback T Silverberg M Buitelaar J 《Child and adolescent psychiatry and mental health》2008,2(1):31-15
Background
Children with attention-deficit/hyperactivity disorder (ADHD) often experience problems with education, interaction with others and emotional disturbances. Families of ADHD children also suffer a significant burden, in terms of strain on relationships and reduced work productivity. This parent survey assessed daily life for children with ADHD and their families.Method
This pan-European survey involved the completion of an on-line questionnaire by parents of children (6–18 years) with ADHD (ADHD sample) and without ADHD (normative population sample). Parents were questioned about the impact of their child's ADHD on everyday activities, general behaviour and family relationships.Results
The ADHD sample comprised 910 parents and the normative population sample 995 parents. 62% of ADHD children were not currently receiving medication; 15% were receiving 6–8 hour stimulant medication and 23% 12-hour stimulant medication. Compared with the normative population sample, parents reported that ADHD children consistently displayed more demanding, noisy, disruptive, disorganised and impulsive behaviour. Significantly more parents reported that ADHD children experienced challenges throughout the day, from morning until bedtime, compared with the normative population sample. Parents reported that children with ADHD receiving 12-hour stimulant medication experienced fewer challenges during early afternoon and late afternoon/early evening than children receiving 6–8 hour stimulant medication; by late evening and bedtime however, this difference was not apparent. ADHD was reported to impact most significantly on activities such as homework, family routines and playing with other children. All relationships between ADHD children and others were also negatively affected, especially those between parent and child (72% of respondents). Parents reported that more children with ADHD experienced a personal injury in the preceding 12 months, including those requiring the attention of healthcare professionals. Although 68% of parents were satisfied with their child's current treatment, 35–40% stated that their child's ADHD symptoms needed to be more effectively treated during the afternoon and evening.Conclusion
This parent survey highlights the breadth of problems experienced by ADHD children and the impact throughout the day on both activities and relationships. Therefore, there is a need for treatment approaches that take into account the 24-hour impact of the disorder and include all-day coverage with effective medication. 相似文献112.
Jian-Hua Li Tuo Chen Hao Xing Rui-Dong Li Cong-Huan Shen Quan-Bao Zhang Yi-Feng Tao Zheng-Xin Wang 《Hepatobiliary & pancreatic diseases international : HBPD INT》2023,22(3):245-252
Background: Liver transplantation(LT) is the “cure” therapy for patients with hepatocellular carcinoma(HCC). However, some patients encounter HCC recurrence after LT. Unfortunately, there is no effective methods to identify the LT patients who have high risk of HCC recurrence and would benefit from adjuvant targeted therapy. The present study aimed to establish a scoring system to predict HCC recurrence of HCC patients after LT among the Chinese population, and to evaluate whether these patients... 相似文献
113.
Yip Ronald ML Cheung Tommy T So Ho Chan Julia PS Ho Carmen TK Tsang Helen HL Yu Carrel KL Wong Priscilla CH 《Clinical rheumatology》2023,42(8):2013-2027
Clinical Rheumatology - Gout is one of the most common noncommunicable diseases in Hong Kong. Although effective treatment options are readily available, the management of gout in Hong Kong remains... 相似文献
114.
Temporal filtering of afferent information is an intrinsic component of the processing of numerous types of sensory information. To date, no temporal filtering mechanism has been identified for nociceptive information. The phenomenon of offset analgesia, the disproportionately large decrease in perceived pain following slight decreases in noxious thermal intensity, however, suggests the existence of such a mechanism. To test the hypothesis that a temporal filtering mechanism is engaged during noxious stimulus offset, subjects rated heat pain intensity while stimulus fall rates were varied from -0.5 to -5.0 degrees C/s. In the absence of a temporal filtering mechanism, pain intensity would be expected to decrease in direct proportion to the stimulus fall rate. However, psychophysical fall rates were considerably faster than stimulus fall rates, such that subjects reported no pain while stimulus temperatures were clearly within the noxious range (47.2 degrees C). In addition, paired noxious stimuli were presented simultaneously to determine if offset analgesia evoked by one stimulus could inhibit pain arising from a separate population of primary afferent neurons. Pain ratings were significantly lower than those reported from two constant 49 degrees C stimuli when offset analgesia was induced proximal to, but not distal to, a second noxious stimulus. These asymmetric spatial interactions are not readily explained by peripheral mechanisms. Taken together, these findings indicate that offset analgesia is mediated in part by central mechanisms and reflect a temporal filtering of the sensory information that enhances the contrast of dynamic decreases in noxious stimulus intensity. 相似文献
115.
116.
117.
CH Shiboski 《Oral diseases》2002,8(S2):44-48
OBJECTIVES: The goals of this literature review were to (1) update a prior review [Shiboski CH (1997) The epidemiology of HIV-related oral manifestations in women: a review. Oral Dis 3: S18–S27] of studies on the epidemiology of HIV-related oral manifestations in women prior to the availability of highly active antiretroviral therapy (HAART); (2) explore the effect of HAART on HIV-related oral disease among women; and (3) explore future research directions with respect to HIV-related oral disease epidemiology among African women.
METHODS: A computer-assisted search was conducted to identify studies on the prevalence of oral conditions in HIV-infected women in relation to immunological markers and HAART [excluding studies reviewed in Shiboski CH (1997) The epidemiology of HIV-related oral manifestations in women: a review. Oral Dis 3: S18–S27]. Results were summarized and discussed for (1) studies conducted in the developed world prior to and during the era of HAART; and (2) studies conducted in sub-Saharan Africa.
RESULTS: Candidiasis (OC) is the most common oral lesion among HIV-infected women, and has been found to be associated with a low CD4 count and a high plasma viral load. Preliminary findings suggest that HAART is associated with a decreasing OC incidence. The few studies identified on HIV-related oral disease in African women suggest that OC is also a common condition in this setting.
CONCLUSION: Future oral epidemiology research efforts in Africa should focus on the potential role of OC as sentinel marker of HIV infection and disease progression, to improve detection and prevention of selected opportunistic illnesses. 相似文献
METHODS: A computer-assisted search was conducted to identify studies on the prevalence of oral conditions in HIV-infected women in relation to immunological markers and HAART [excluding studies reviewed in Shiboski CH (1997) The epidemiology of HIV-related oral manifestations in women: a review. Oral Dis 3: S18–S27]. Results were summarized and discussed for (1) studies conducted in the developed world prior to and during the era of HAART; and (2) studies conducted in sub-Saharan Africa.
RESULTS: Candidiasis (OC) is the most common oral lesion among HIV-infected women, and has been found to be associated with a low CD4 count and a high plasma viral load. Preliminary findings suggest that HAART is associated with a decreasing OC incidence. The few studies identified on HIV-related oral disease in African women suggest that OC is also a common condition in this setting.
CONCLUSION: Future oral epidemiology research efforts in Africa should focus on the potential role of OC as sentinel marker of HIV infection and disease progression, to improve detection and prevention of selected opportunistic illnesses. 相似文献
118.
用放射性同位素的方法研究了丁基苯肽(NBP)在大鼠体内代谢,并对代谢产物进行了鉴定。结果表明,大鼠ig3HNBP后24h,从尿和粪中排出的放射性分别为ig剂量的552%和185%,排除了药物蓄积在体内的可能性;用高效液相色谱法分离、纯化了丁基苯酞的两个主要的体外代谢产物代I和代I,根据代I和代II的波谱数据(UV,1HNMR,MS)确定了它们的化学结构;薄层色谱(TLC)证明丁基苯酞的体内代谢产物同样有代I和代I,并且也是两个主要的代谢产物;大鼠ig3HNBP后1h,脑中原型药与代谢物的比例为1∶1,而且只发现有代I,未发现有代I,推测代I很有可能是活性代谢产物。 相似文献
119.
120.
CH. OLOFSSON 《Acta anaesthesiologica Scandinavica》1997,41(8):1091-1091
Abstract: Labour and delivery involve severe pain for most women. The goal for pain treatment in obstetrics is to provide effective and safe analgesia during all phases of delivery. The ideal method for pain relief during delivery is not yet available. This thesis aims at studying some aspects of opioids in obstetric pain treatment with respect to analgesic efficacy and side-effects, and to analyse pain during delivery from a neurobiological perspective. 相似文献