全文获取类型
收费全文 | 2916篇 |
免费 | 176篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 87篇 |
妇产科学 | 30篇 |
基础医学 | 413篇 |
口腔科学 | 94篇 |
临床医学 | 358篇 |
内科学 | 587篇 |
皮肤病学 | 72篇 |
神经病学 | 384篇 |
特种医学 | 131篇 |
外科学 | 366篇 |
综合类 | 6篇 |
一般理论 | 3篇 |
预防医学 | 245篇 |
眼科学 | 47篇 |
药学 | 129篇 |
中国医学 | 1篇 |
肿瘤学 | 130篇 |
出版年
2023年 | 16篇 |
2022年 | 22篇 |
2021年 | 52篇 |
2020年 | 45篇 |
2019年 | 48篇 |
2018年 | 54篇 |
2017年 | 59篇 |
2016年 | 86篇 |
2015年 | 59篇 |
2014年 | 90篇 |
2013年 | 193篇 |
2012年 | 193篇 |
2011年 | 198篇 |
2010年 | 126篇 |
2009年 | 145篇 |
2008年 | 186篇 |
2007年 | 193篇 |
2006年 | 174篇 |
2005年 | 205篇 |
2004年 | 169篇 |
2003年 | 161篇 |
2002年 | 154篇 |
2001年 | 37篇 |
2000年 | 28篇 |
1999年 | 39篇 |
1998年 | 29篇 |
1997年 | 22篇 |
1996年 | 21篇 |
1995年 | 25篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 23篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 7篇 |
1988年 | 12篇 |
1987年 | 13篇 |
1986年 | 9篇 |
1985年 | 15篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1979年 | 9篇 |
1978年 | 13篇 |
1977年 | 5篇 |
1972年 | 5篇 |
1971年 | 6篇 |
1970年 | 8篇 |
1966年 | 7篇 |
排序方式: 共有3098条查询结果,搜索用时 588 毫秒
51.
Using administrative data from Norway, we examine the extent to which family doctors influence their clients’ propensity to claim sick-pay. The analysis exploits exogenous switches of family doctors occurring when physicians quit, retire, or for other reasons sell their patient lists. We find that family doctors have significant influence on their clients’ absence behavior, particularly on absence duration. Their influence is stronger in geographical areas with weaker competition between physicians. We conclude that it is possible for family doctors to contain sick-pay expenditures to some extent, and that there is a considerable variation in the way they perform this task. 相似文献
52.
53.
54.
Else-Marie Dalsgaard Jesper O. Christensen Mette Vinter Skriver Knut Borch-Johnsen Torsten Lauritzen Annelli Sandbaek 《Primary Care Diabetes》2010,4(4):223-229
AimTo examine attendance, number of people with T2DM and costs of three different stepwise screening strategies for T2DM in general practice (GP).MethodsDiabetes risk questionnaires were mailed to individuals aged 40–69 years from 45 general practices in 2001–2002 and individuals at high risk for T2DM, were asked to contact their GP to arrange a screening test. In 2005–2006, 26 general practices were randomised into two different opportunistic screening programmes (OP-direct and OP-subsequent) and risk questionnaires were distributed to individuals aged 40–69 years during GP consultations. In the OP-direct approach, high-risk individuals were offered to start the screening during the actual consultation while high-risk individuals in the OP-subsequent approach, were invited to a screening test at a later date. We report attendance, number of people with T2DM and costs of each screening approach.ResultsThe mail-distributed approach identified 0.8% of the target population with T2DM, the OP-direct approach and the OP-subsequent approach, 0.9% and 0.5% respectively. Cost per person with T2DM was in the mail-distributed approach: € 1058, OP-direct approach: € 707 and the OP-subsequent approach: € 727.ConclusionThis study indicates that opportunistic screening identifies the same level of unknown diabetes as a mail-distributed approach but with lower costs. 相似文献
55.
56.
BACKGROUND: In patients with early manifestation of peripheral arterial occlusive disease (PAOD) and a less classical atherosclerotic risk profile, vasculitis is presumed to be the underlying disease. We performed a prospective study of the importance of determination of autoantibodies used for the diagnosis of vasculitis and collagen diseases in patients with symptomatic PAOD. PATIENTS AND METHOD: 698 consecutive patients (mean age +/- SD: 68 +/- 10 years) were included who were referred from 1998 to 1999 for interventional treatment of PAOD. In 121 PAOD-patients (61 +/- 12 years) with a less pronounced atherosclerotic risk profile, or rarefied distal arteries without sclerosis of the media, or elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) independent from the stage IV of PAOD, the following autoantibodies were investigated: antinuclear antibodies (ANA), antibodies against extractable nuclear antigens (ENA): SCL 70, RNP, SS-A, SS-B, Jo-1, SM), double-stranded DNA antibodies (ds-DNA), antineutrophil cytoplasmatic antibodies (c- and p-ANCA), antiphospholipid antibodies [phosphatidylserine (APSA) and beta(2)-glycoprotein], smooth (SMA) and striated muscle (StrMA). ANA, SMA and StrMA were estimated by indirect immunofluorescence technique, ENA by Western-blot and the others by enzyme linked immunoassay. RESULTS: 38 PAOD-patients (35%) had increased autoantibody concentrations. The rate of different PAOD stages and localization did not differ between the group of patients with increased autoantibody concentrations and the group of patients without. But the group of patients with increased autoantibody concentrations had higher rates of elevated ESR [p-value of 0.0043, odds ratio of 7.1 (95% CI: 1.49-33.81)]. ANA were the most frequent autoantibodies detected in 17 (14%) of the 121 patients followed by APSA and autoantibodies directed against beta(2)-glycoprotein. During follow-up of 24 +/- 6 months no vasculitis or collagen diseases associated with the elevated autoantibody concentrations became clinically manifest in the 38 patients. Two patients died due to coronary heart disease. Four patients had a worsening of their PAOD but no amputation was performed. Out of the 83 patients without elevated concentrations of autoantibodies, eight patients died and three amputations were carried out. CONCLUSION: All in all, increased autoantibody concentrations in patients suffering from peripheral atherosclerosis are not a rare finding. A systematic determination of autoantibodies, especially in patients with a low atherosclerotic risk profile, does not increase the number of manifest or developing vasculitis of collagen disease. 相似文献
57.
Omdal R Waterloo K Koldingsnes W Husby G Mellgren SI 《The Journal of rheumatology》2003,30(2):283-287
OBJECTIVE: Studies to prove a relationship between fatigue and immunological, inflammatory, or other disease characteristics of systemic lupus erythematosus (SLE) have shown no consistent findings. To further elucidate the basis for fatigue in SLE, we examined the affective states, personality traits, and mental health status in an unselected group of patients with SLE. METHODS: Fifty-seven Caucasian patients with SLE were examined. Fatigue was measured by the Fatigue Severity Scale. Personality traits and psychological function were evaluated by the Minnesota Multiphasic Personality Inventory-2 (MMPI-2), the affective states by Beck Depression Inventory, and mental health status by the General Health Questionnaire version 30 (GHQ-30). RESULTS: Fatigue was closely associated with high scores on subscales Depression (D-2) and Hysteria (Hy-3) on MMPI-2 (R2 = 0.31; p = 0.0002), as well as with high scores on BDI (R2 = 0.22; p = 0.0006) and GHQ (R2 = 0.33; p < 0.0001). CONCLUSION: Fatigue does not seem to be caused by any easily recognizable single or multiple factor(s) of an inflammatory or immunological state. Our results point to fatigue being a multifaceted phenomenon where several psychosocial factors are strongly related, and indicate that fatigue is part of a complex response to chronic disease. 相似文献
58.
59.
Alison M. Dines David M. Wood Miguel Galicia Christopher M. Yates Fridtjof Heyerdahl Knut Erik Hovda Isabelle Giraudon Roumen Sedefov Paul I. Dargan Euro-DEN Research Group 《Journal of medical toxicology》2015,11(4):415-421
Cannabis is the most commonly used illicit drug in Europe, and is generally regarded
as having low acute toxicity. We present the findings of the first 6 months of data collection from
the Euro-DEN project on presentations related to cannabis use to further understand the acute
toxicity related to the use of cannabis. Data was extracted on clinical features, treatment and
outcome from the Euro-DEN minimum dataset for all cases of acute recreational drug toxicity reported
1st October 2013 to 31st March 2014 for all cannabis-related presentations. Of 2198 presentations
reported by 14 of the 16 Euro-DEN centres, 356 (16.2 %) involved cannabis either alone or together
with other drugs/alcohol. There were 36 that involved lone use of cannabis (1.6 % of all
presentations). Of the 35 non-fatal lone cannabis presentations, the most commonly reported features
were neuro-behavioural (agitation/aggression 8 (22.9 %), psychosis 7 (20.0 %), anxiety 7 (20.0 %))
and vomiting 6 (17.1 %). Most patients (25, 71.4 %) received no treatment and 30 (85.7 %) were
discharged/self-discharged from the ED. There was one fatality amongst these lone-cannabis cases: an
18-year-old male collapsed with an asystolic cardiac arrest whilst smoking cannabis and suffered
hypoxic brain injury related to prolonged cardiac arrest. THC was detected in a urine sample taken
at ED arrival; no other drugs were detected. Lone acute cannabis toxicity was typically associated
with neuro-behavioural symptoms and vomiting. Although uncommon, severe toxicity including
cardiovascular toxicity and death may be under-recognised, and it is important that Emergency
Physicians are aware of this. 相似文献
60.
Marcel K?hn Christian Ihling Andrea Sinz Knut Krohn Stefan Hüttelmaier 《Genes & development》2015,29(19):1998-2003
We demonstrate that the Y3/Y3** noncoding RNAs (ncRNAs) bind to the CPSF (cleavage and polyadenylation specificity factor) and that Y3** associates with the 3′ untranslated region (UTR) of histone pre-mRNAs. The depletion of Y3** impairs the 3′ end processing of histone pre-mRNAs as well as the formation and protein dynamics of histone locus bodies (HLBs), the site of histone mRNA synthesis and processing. HLB morphology is also disturbed by knockdown of the CPSF but not the U7-snRNP components. In conclusion, we propose that the Y3** ncRNA promotes the 3′ end processing of histone pre-mRNAs by enhancing the recruitment of the CPSF to histone pre-mRNAs at HLBs. 相似文献