全文获取类型
收费全文 | 1477093篇 |
免费 | 104303篇 |
国内免费 | 2347篇 |
专业分类
耳鼻咽喉 | 20834篇 |
儿科学 | 48442篇 |
妇产科学 | 41953篇 |
基础医学 | 216316篇 |
口腔科学 | 40275篇 |
临床医学 | 124300篇 |
内科学 | 294854篇 |
皮肤病学 | 32094篇 |
神经病学 | 117864篇 |
特种医学 | 56082篇 |
外国民族医学 | 457篇 |
外科学 | 222635篇 |
综合类 | 27338篇 |
现状与发展 | 1篇 |
一般理论 | 360篇 |
预防医学 | 110962篇 |
眼科学 | 33126篇 |
药学 | 112119篇 |
1篇 | |
中国医学 | 3096篇 |
肿瘤学 | 80634篇 |
出版年
2019年 | 11483篇 |
2018年 | 18446篇 |
2017年 | 13340篇 |
2016年 | 14499篇 |
2015年 | 16511篇 |
2014年 | 21084篇 |
2013年 | 32576篇 |
2012年 | 47947篇 |
2011年 | 50264篇 |
2010年 | 28330篇 |
2009年 | 25309篇 |
2008年 | 47239篇 |
2007年 | 51015篇 |
2006年 | 50478篇 |
2005年 | 49652篇 |
2004年 | 47409篇 |
2003年 | 45450篇 |
2002年 | 44458篇 |
2001年 | 62864篇 |
2000年 | 64420篇 |
1999年 | 54944篇 |
1998年 | 15054篇 |
1997年 | 13499篇 |
1996年 | 13681篇 |
1995年 | 12923篇 |
1994年 | 12267篇 |
1992年 | 43450篇 |
1991年 | 42558篇 |
1990年 | 42030篇 |
1989年 | 40629篇 |
1988年 | 37908篇 |
1987年 | 36974篇 |
1986年 | 35261篇 |
1985年 | 33568篇 |
1984年 | 24984篇 |
1983年 | 21726篇 |
1982年 | 12933篇 |
1981年 | 11379篇 |
1979年 | 23606篇 |
1978年 | 16539篇 |
1977年 | 14337篇 |
1976年 | 13495篇 |
1975年 | 14839篇 |
1974年 | 17467篇 |
1973年 | 16885篇 |
1972年 | 16054篇 |
1971年 | 14969篇 |
1970年 | 13909篇 |
1969年 | 13465篇 |
1968年 | 12619篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Christopher G. Acker Richard Flick Ron Shapiro Velma P. Scantlebury Mark L. Jordan Carlos Vivas Arthur Greenberg John P. Johnson 《American journal of transplantation》2002,2(1):57-61
Delayed graft function (DGF) in cadaver kidney transplants is a common problem and is often due to acute tubular necrosis (ATN). DGF in transplants may have a deleterious effect on long-term graft survival. Since thyroid hormone has been shown to hasten recovery from ATN in experimental models, we designed a trial to determine if a defined course of triiodothyronine (T3) would improve the short- or long-term outcome of patients with DGF in cadaveric transplants. A prospective, randomized, placebo controlled, double blind trial of T3 was carried out in patients with DGF in cadaveric renal transplants. End-points were percentage requiring dialysis, percentage recovering function, time to recovery and length of hospital stay. Long-term outcomes were percentage grafts functioning at 1 year and mean serum creatinine at 1 year. Forty-four patients were randomized to receive either T3 or placebo. Three patients were dropped from each group when early biopsies disclosed that DGF was due to rejection. The groups were well matched by age, cold ischemia time of the graft, and percentage reactivity to a random panel of antigens. Baseline thyroid function studies, including T3, reverse T3 (rT3), and thyroid stimulating hormone (TSH) levels, were similar between the two groups and typical of 'euthyroid-sick syndrome'. T3 had no effect on percentage requiring dialysis, time to recovery, percentage recovering function, or length of stay. At 1 year follow-up, graft function was similar in both groups and significantly lower than that seen in patients with good initial function. Thyroid hormone, given early in the course of DGF in cadaver kidney recipients, had no effect on the course of DGF. Long-term graft function is impaired in patients who experience post-transplant DGF compared to those who have good initial function. 相似文献
992.
Infantile Digital Fibroma Treated With Mohs Micrographic Surgery 总被引:2,自引:0,他引:2
John G. Albertini MD Maj USAF MC Michael Jude Welsch MD CPT USA MC Leo A. Conger MD LTC USA MC Lester F. Libow MD COL USA MC Dirk M. Elston MD COL USA MC 《Dermatologic surgery》2002,28(10):959-961
BACKGROUND: Infantile digital fibroma (IDF) is a rare benign fibrous tumor of childhood that frequently recurs despite local excision. Conservative, nonsurgical management may result in regression and/or joint deformity. OBJECTIVE: To describe the histologic features of IDF and discuss a case excised using Mohs micrographic surgery (MMS). METHODS: Case report and review of the clinical, histologic, and ultrastructural features. RESULTS: Characteristic inclusion bodies of actin were identified with hematoxylin and eosin, Masson's trichrome, and rapid actin immunostain. The tumor was debulked and the majority was removed after one stage of MMS, except where the deep margin approached the joint space. The defect healed by secondary intention. At 2 years the patient had no recurrence or functional joint deformity. CONCLUSION: MMS is a surgical treatment option for IDF. 相似文献
993.
M Hansrani K Overbeck J Smout G Stansby 《European journal of vascular and endovascular surgery》2002,24(5):377-382
INTRODUCTION: Intravascular brachytherapy (IVBT) utilises the percutaneous insertion of a radioactive source to inhibit myointimal hyperplasia in arteries treated by balloon angioplasty or stenting. A systematic review was performed of trials of IVBT in patients with Peripheral Arterial Disease (PAD). METHODS: Search strategy - the reviewers searched Medline, Embase, the Cochrane Peripheral Vascular Diseases Group trials register, DARE, CCT and NHS EED for clinical studies and trials of adjuvant IVBT in PAD. Two reviewers assessed trial quality independently. RESULTS: Fourteen clinical trials were identified by the search, representing five clinical studies (all allocated D for not randomised) and one randomised controlled trial (allocated A). The randomised trial showed a benefit for IVBT compared with placebo (OR 0.35, 95% CI 0.24-0.53). In the non-randomised studies, 12 month cumulative patency rates ranged from 60-87%. There were few technical complications. In the only report involving IVBT and routine concurrent stent insertion acute thrombosis occurred in 7 (21%) of patients. CONCLUSION: Early reports have confirmed the safety and technical feasibility of IVBT. However, follow-up is too short at present to assess the durability and long-term complications of this new therapeutic option. 相似文献
994.
Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells 总被引:2,自引:0,他引:2
U. Krehmeier M. Bardenheuer G. Voggenreiter U. Obertacke F. U. Schade M. Majetschak 《Journal of infection and chemotherapy》2002,8(2):194-197
Because the immunomodulatory effects of antibiotics could possibly influence the degree of the systemic and local response
to infection, knowledge of their intrinsic influence on the host's inflammatory response appears to be essential. Therefore,
this study investigated the effects of frequently used antimicrobial agents (β-lactams, quinolones gentamicin, vancomycin
and metronidazole) on the in-vitro tumor necrosis factor (TNF)-α and interleukin (IL)-6 production of isolated human peripheral
blood mononuclear cells (PBMNC), cultured with or without endotoxin, in comparison with those effects obtained in a whole-blood
assay system. In the presence of ciprofloxacin, ofloxacin, gentamicin, vancomycin, and metronidazole, a significant inhibition
of the endotoxin-stimulated TNF-α production of human peripheral blood mononuclear cells (PBMNC) was found at therapeutic
levels. Only ofloxacin showed a significant inhibitory influence on the endotoxin-induced IL-6 production of PBMNC. In the
whole-blood assay, significant effects were not detectable. None of the antibiotics showed cytotoxicity. It is concluded that,
at present, the direct immunological effects of antibiotics should be interpreted carefully with regard to the experimental
conditions, and regardless of the therapeutic implications. To assess the potential direct immunomodulatory effect of antimicrobial
agents, different cell culture procedures should be used.
Received: October 19, 2001 / Accepted: February 15, 2002 相似文献
995.
Dr. med. A. Schultze-Mosgau G. Griesinger S. von Otte K. Diedrich 《Gyn?kologische Endokrinologie》2005,3(4):219-225
Since the introduction of in vitro fertilization in 1978, reproductive medicine and its associated scientific fields have developed rapidly. In Germany, progress in this field is impeded by the German Embryo Protection Act. Exemplary are the prohibition of embryo selection and the ban on genetic testing of the pre-implantation embryo. Nevertheless, infertility treatment outcome has to be optimized within the framework of this law, with the aim of making treatment more efficient, lowering the incidence of multiple gestations, making ovarian hyperstimulation safer, as well as reducing the financial costs for the couple. 相似文献
996.
Reductions in substance use tend to coincide with marriage, as both may occur during emerging adulthood. During the transition to marriage, it is possible that one's spouse may be the influence that causes the reduction in substance use. Data on participants (N = 471 couples) for this report are taken from a longitudinal study of early marriage. The objective of the current analysis is to determine if having a spouse who uses marijuana is associated with a greater likelihood of one's own use. Additionally, we are interested in spousal influence and cessation. The findings support spousal influence. Husbands are more likely to start using marijuana if their wives use marijuana, but the reverse is not true. Husbands also are more likely to stop using if their spouses do not use. During the transition into marriage, the drug use of one spouse does affect the other. However, this influence appears to be unidirectional, with wives influencing their husbands more often. 相似文献
997.
é. Cavro elodiecavro@hotmail.fr C. Bungener Catherine.Bungener@univ-paris.fr A. Bioy antoine.bioy@bct.aphp.fr 《Revue Francophone de Psycho-Oncologie》2005,4(2):74-79
Résumé: La rémission du cancer peut être l’occasion pour certains patients d’une réelle détresse émotionnelle ainsi que d’une désadaptation psychologique appelées: syndrome de Lazare. Nous émettons trois hypothèses explicatives quant à la survenue de tels troubles. La première confronte l’issue du cancer aux concepts psychanalytiques de dette et de masochisme. La deuxième envisage les symptômes sous l’angle d’une réaction de sevrage. Et la dernière évoque le contrecoup traumatique des traitements.Dossier: «Cliniques du cancer» 相似文献
998.
999.
Timothy J Halligan Nathan G Russell William J Dunn Steven J Caldroney Timothy B Skelton 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(6):688-692
Scurvy is a nondiscriminatory disease process resulting from a nutritional deficiency of ascorbic acid (vitamin C). The severe vitamin deficiency produces a breakdown in the cellular structure of the body. This case report describes a middle-age woman with a history of edema, bruising of the lower extremities, anemia, and severe periodontal disease. Her presentation and medical history are classic for the signs of scurvy. Scurvy is now only uncommonly seen in developed countries, but there are still vulnerable populations whose nutritional status can lead to scurvy. The aim of this report is to help the clinician identify and treat scurvy, a disease that was once feared for its high mortality but is now easily treatable, even in cases that have progressed to multiple organ dysfunction and failure. 相似文献
1000.