5-HT(1A) receptor binding changes in patients with major depressive disorder before and after antidepressant treatment: A pilot [(18)F]MPPF positron emission tomography study

This is the first [(18)F]MPPF PET study in positron emission tomography study in depressed patients, both before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Dynamic changes in [(18)F]MPPF binding potential were observed primarily in the medial orbital regions from baseline to 30days of treatment, suggesting SSRI-mediated serotoninergic adaptative mechanisms.     

Hyperactivity-inattention symptoms in childhood and suicidal behaviors in adolescence: the Youth Gazel Cohort

Objective: Although a link has been suggested between attention deficit/hyperactivity disorder (ADHD) and completed suicide, little is known about the association with suicidal behaviors in community settings. This study addresses the relationship between childhood hyperactivity‐inattention symptoms (HI‐s) and subsequent suicidal behaviors. Method: Nine hundred sixteen subjects aged 7–18 were recruited from the general population and surveyed in 1991 and 1999. Parent and adolescent self‐reports provided psychopathology and suicidal behavior pattern measures. Multivariate modeling was used to evaluate the effects of childhood HI‐s and other risk factors on adolescent suicidal behaviors. Results: In males, HI‐s independently accounted for the risk of lifetime suicide plans/attempts (OR=3.25, P = 0.02) and adolescent 12‐month prevalence rates of suicide plans/attempts (OR=5.46, P = 0.03). In females, HI‐s did not independently heighten the likelihood of suicidal behaviors. Conclusion: This survey suggests a possible specific link between HI‐s and suicide plans/attempts in males.     

Expressions rhumatologiques paranéoplasiques

Paraneoplastic syndromes are characterized by different signs and symptoms related to an occult or already identified tumour, without any anatomical relationship between the paraneoplastic manifestations and the tumour. The nature of the tumour is usually malignant but it may happen to be benign. If the tumoural treatment is efficient, resulting in true recovery, the paraneoplastic manifestations disappear and do not relapse, except in case of tumour relapse. A rheumatic paraneoplastic syndrome is different from a pre-neoplastic situation. Many rheumatic conditions may be discussed, in addition to other neurologic and dermatologic paraneoplastic syndromes. Main rheumatic paraneoplastic entities are discussed in the present paper: palmar fasciitis syndrome with polyarthritis, paraneoplastic osteomalacia, secondary hypertrophic osteoarthropathy, paraneoplastic hypercalcemia, paraneoplastic inflammatory rheumatisms, muscular paraneoplastic syndromes and paraneoplastic vasculitides.