全文获取类型
收费全文 | 234篇 |
免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 7篇 |
妇产科学 | 3篇 |
基础医学 | 18篇 |
临床医学 | 17篇 |
内科学 | 24篇 |
皮肤病学 | 2篇 |
神经病学 | 61篇 |
特种医学 | 20篇 |
外科学 | 39篇 |
预防医学 | 3篇 |
药学 | 5篇 |
肿瘤学 | 38篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 5篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 10篇 |
2013年 | 19篇 |
2012年 | 20篇 |
2011年 | 15篇 |
2010年 | 11篇 |
2009年 | 14篇 |
2008年 | 12篇 |
2007年 | 11篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 6篇 |
2002年 | 9篇 |
2001年 | 9篇 |
2000年 | 12篇 |
1999年 | 12篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1975年 | 1篇 |
排序方式: 共有239条查询结果,搜索用时 15 毫秒
41.
Besson FL Parienti JJ Bienvenu B Prior JO Costo S Bouvard G Agostini D 《European journal of nuclear medicine and molecular imaging》2011,38(9):1764-1772
Purpose
The aim of this study was to conduct a systematic review and perform a meta-analysis on the diagnostic performances of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for giant cell arteritis (GCA), with or without polymyalgia rheumatica (PMR). 相似文献42.
43.
A randomized controlled trial of cognitive therapy versus intensive behavior therapy in obsessive compulsive disorder 总被引:7,自引:0,他引:7
Cottraux J Note I Yao SN Lafont S Note B Mollard E Bouvard M Sauteraud A Bourgeois M Dartigues JF 《Psychotherapy and psychosomatics》2001,70(6):288-297
BACKGROUND: The study was designed to compare cognitive therapy (CT) with intensive behavior therapy (BT) in obsessive-compulsive disorder (OCD) and to study their change process. METHODS: Sixty-five outpatients with DSM-4 OCD were randomized into 2 groups for 16 weeks of individual treatment in 3 centers. Group 1 received 20 sessions of CT. Group 2 received a BT program of 20 h in two phases: 4 weeks of intensive treatment (16 h), and 12 weeks of maintenance sessions (4 h). No medication was prescribed. RESULTS: Sixty-two patients were evaluated at week 4, 60 at week 16 (post-test), 53 at week 26 and 48 at week 52 (follow-up). The response rate was similar in the 2 groups. The Beck Depression Inventory (BDI) was significantly more improved by CT (p = 0.001) at week 16. The baseline BDI and Obsessive Thoughts Checklist scores predicted a therapeutic response in CT, while the baseline BDI score predicted a response in BT. At week 16, only the changes in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and a scale measuring the interpretation of intrusive thoughts correlated in CT, while the changes in Y-BOCS, BDI, and interpretation of intrusive thoughts correlated in BT. Improvement was retained at follow-up without a between-group difference. The intent-to-treat analysis (last observation carried forward) found no between-group differences on obsessions, rituals and depression. CONCLUSIONS: CT and BT were equally effective on OCD, but at post-test CT had specific effects on depression which were stronger than those of BT. Pathways to improvement may be different in CT and BT. The outcomes are discussed in the light of an effect size analysis. 相似文献
44.
Karine Briot Julien Paccou Philippe Beuzeboc Jacques Bonneterre Béatrice Bouvard Cyrille B. Confavreux Catherine Cormier Bernard Cortet Jean-Michel Hannoun-Lévi Christophe Hennequin Rose-Marie Javier Eric Lespessailles Didier Mayeur Pierre Mongiat Artus Marie-Hélène Vieillard Françoise Debiais 《Revue du Rhumatisme》2019,86(2):125-133
45.
Cogliano VJ Baan R Straif K Grosse Y Lauby-Secretan B El Ghissassi F Bouvard V Benbrahim-Tallaa L Guha N Freeman C Galichet L Wild CP 《Journal of the National Cancer Institute》2011,103(24):1827-1839
Information on the causes of cancer at specific sites is important to cancer control planners, cancer researchers, cancer patients, and the general public. The International Agency for Research on Cancer (IARC) Monograph series, which has classified human carcinogens for more than 40 years, recently completed a review to provide up-to-date information on the cancer sites associated with more than 100 carcinogenic agents. Based on IARC's review, we listed the cancer sites associated with each agent and then rearranged this information to list the known and suspected causes of cancer at each site. We also summarized the rationale for classifications that were based on mechanistic data. This information, based on the forthcoming IARC Monographs Volume 100, offers insights into the current state-of-the-science of carcinogen identification. Use of mechanistic data to identify carcinogens is increasing, and epidemiological research is identifying additional carcinogens and cancer sites or confirming carcinogenic potential under conditions of lower exposure. Nevertheless, some common human cancers still have few (or no) identified causal agents. 相似文献
46.
Guerrini JS Bouvard V Oswald E Alonso A Prétet JL Tommasino M Mougin C Aubin F 《Experimental dermatology》2011,20(1):71-73
Beta-papillomaviruses (beta-HPV) have been linked to the development of skin cancer in humans. Because both E6 and E7 proteins from beta-HPV have been involved in the potential carcinogenicity of these viruses, we investigated their role on UVB-induced apoptosis in HaCaT cell line. HaCaT cells have been transduced with both E6/E7 using a retroviral system and treated with PRIMA-1. Apoptosis was assessed by flow cytometry to measure mitochondrial membrane potential and DNA fragmentation. HaCat keratinocytes transduced with both E6 and E7 genes of seven beta-HPV types (HPV5, HPV8, HPV14, HPV24, HPV36, HPV38 and HPV49) did not demonstrate any inhibition of UVB-induced apoptosis, even after p53 reactivation through PRIMA-1. Our data suggest that the expression of E6 and E7 exert different modulatory effects on UVB-induced apoptosis according to beta-HPV types and to the cellular genetic context. 相似文献
47.
Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort 下载免费PDF全文
Cédric Galera Barbara Heude Anne Forhan Jonathan Y. Bernard Hugo Peyre Judith Van der Waerden Laura Pryor Manuel‐Pierre Bouvard Maria Melchior Sandrine Lioret Blandine de Lauzon‐Guillain the EDEN Mother–Child Cohort Study Group 《Journal of child psychology and psychiatry, and allied disciplines》2018,59(9):1003-1011
48.
49.
Jean Cottraux Daniel Grard Luc Cinotti Jean-Claude Froment Marie-Pierre Deiber Didier Le Bars Grard Galy Philippe Millet Claire Labb Frank Lavenne Martine Bouvard Franois Mauguire 《Psychiatry research》1996,60(2-3):101-112
Ten nondepressed patients with obsessive-compulsive disorder (OCD) who were characterized by predominant checking rituals were compared with 10 age- and sex-matched control subjects. Hemispheric and regional cerebral blood flow levels (rCBF) were measured with positron emission tomography (H215O) across four conditions: rest, auditory stimulation with idiosyncratic normal or abnormal obsession, auditory stimulation with neutral verbal stimuli, and rest. Order of neutral and obsessive stimulation was randomized. Higher subjective responses to obsessive than to neutral stimulation were found in both groups; subjective response was higher in OCD patients when obsessive stimulation was presented first. A four-way analysis of variance (group × stimulation order × hemisphere × condition [neutral or obsessive stimulation]) was performed on stimulation minus rest normalized rCBF values. Control subjects had significantly higher rCBF in the thalamus and putamen. A trend toward higher rCBF in OCD patients was found in the superior temporal regions. When neutral stimulation was presented first, rCBF was significantly higher in the caudate region of control subjects. Obsessive stimulation was associated with higher rCBF than neutral stimulation in orbitofrontal regions in both groups of subjects. Under obsessive stimulation, superior temporal and orbitofrontal activities were correlated in OCD patients but not in control subjects. Our study suggests specific abnormalities of information processing in the basal ganglia and temporal structures of compulsive checkers. 相似文献
50.
Jean Lacau St Guily Éric Bouvard Bruno Raynard François Goldwasser Brigitte Maget Alain Prevost David Seguy Olivier Romano Bérengère Narciso Charles Couet Jean-Michel Balon Damien Vansteene Sébastien Salas Philippe Grandval Emmanuel Gyan Xavier Hebuterne 《Journal of Geriatric Oncology》2018,9(1):74-80