首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   200篇
  免费   29篇
  国内免费   5篇
耳鼻咽喉   1篇
儿科学   17篇
妇产科学   4篇
基础医学   31篇
口腔科学   12篇
临床医学   25篇
内科学   39篇
皮肤病学   3篇
神经病学   11篇
特种医学   28篇
外科学   5篇
综合类   29篇
预防医学   5篇
眼科学   2篇
药学   16篇
肿瘤学   6篇
  2023年   1篇
  2022年   2篇
  2021年   9篇
  2020年   2篇
  2019年   2篇
  2018年   5篇
  2017年   1篇
  2016年   3篇
  2015年   6篇
  2014年   14篇
  2013年   5篇
  2012年   6篇
  2011年   6篇
  2010年   6篇
  2009年   8篇
  2008年   7篇
  2007年   11篇
  2006年   4篇
  2005年   3篇
  2004年   2篇
  2003年   3篇
  2002年   2篇
  2001年   2篇
  2000年   2篇
  1999年   6篇
  1998年   17篇
  1997年   14篇
  1996年   17篇
  1995年   9篇
  1994年   9篇
  1993年   7篇
  1992年   1篇
  1991年   1篇
  1990年   3篇
  1989年   2篇
  1988年   8篇
  1987年   3篇
  1986年   6篇
  1985年   1篇
  1984年   2篇
  1983年   4篇
  1982年   1篇
  1981年   4篇
  1978年   1篇
  1977年   1篇
  1976年   1篇
  1975年   3篇
  1974年   1篇
排序方式: 共有234条查询结果,搜索用时 15 毫秒
71.

Background

170 million people are infected with the Hepatitis C virus (HCV) around the world. Approximately 50%-70% patients infected with HCV develop chronic liver disease. Haemodialysis patients constitute an especially important group with high HCV prevalence. Outbreaks of HCV infection in dialysis units have been documented. Detection of anti-HCV antibodies is a convenient and conventional mode of documentation. However, in this group, it has it''s own caveats.

Methods

48 patients who had undergone or were on haemodialysis (HD) and had undergone a minimum of 15 dialysis sittings were studied. HCV infection was documented both by anti-HCV antibody detection and HCV RNA testing. A comparative evaluation of results by both tests was done.

Results

Out of a total of 48 patients, HCV RNA was detected in 38 (79.16%) and anti-HCV antibodies in 13(27.07%). Out of 48 patients 10(20.83%) were negative for both parameters. 22.91% (11/48) of patients were positive for both HCV RNA and anti-HCV antibody. 56.25% (27/48) were HCV RNA positive but anti-HCV antibodies were not detectable in their sera. 2 patients (04.16%) had a positive anti-HCV antibody status despite HCV RNA being negative. In 20.83% (10/48) both parameters were undetectable.

Conclusion

Chronic liver disease (CLD), particularly due to HCV infection, is a major complication amongst haemodialysis (HD) patients. Without reliable assays for antigenemia and the inability of antibody tests to define viremia in all cases, the detection of viral nucleic acid is necessary for diagnosis of active HCV infection.Key Words: Hepatitis C virus, Haemodialysis  相似文献   
72.
Non-adaptive activation of dopamine transmission in the nucleus accumbens shell by drugs of abuse has been attributed a fundamental role in the mechanism of drug addiction. In order to test this hypothesis, we compared in the same subject the effect of an addictive drug (ethanol) and of taste stimuli, including ethanol's own taste, on dialysate dopamine in the nucleus accumbens shell as an estimate of dopamine transmission and on taste reactivity as an expression of motivational valence. Ethanol was also monitored in the dialysates. In naive rats, intraoral infusion of a 20% sucrose + chocolate solution elicited a monophasic increase of dialysate dopamine immediately after the intraoral infusion. In contrast, intraoral infusion of 10% ethanol, 10% ethanol + 20% sucrose or 10% ethanol + 20% sucrose + chocolate solutions elicited a biphasic increase of nucleus accumbens dopamine with an early taste-related rise and a late rise related to dialysate ethanol. Pre-exposure to the ethanol solutions 24 h before resulted in the absence of the early dopamine rise and permanence of the late dopamine rise. This late dopamine rise was actually increased as compared with that of the nonpre-exposed group when sucrose-containing ethanol solutions were tested. The results indicate that single trial pre-exposure to the ethanol solutions differentially affects the responsiveness of nucleus accumbens shell dopamine to the direct intracerebral action of ethanol and to the effect of its taste with potentiation, or no change of the first and abolition of the second. These observations point to the existence of major differences in the adaptive regulation of nucleus accumbens dopamine transmission in the shell after drug as compared with taste reward. These differences, in turn, are consistent with a role of nucleus accumbens shell dopamine in the mechanism of the behavioural effects of addictive drugs.  相似文献   
73.
74.
75.
76.
77.
Epidemics of cholera caused by Vibrio cholerae 01 occur regularly in India. Until recently, Vibrio cholerae non-01 have been the the causative agents of sporadic cases of gastroenteritis and septicaemia, especially in immunocompromised children. We describe a large outbreak of cholera-like illness from North India caused by Vibrio cholerae non-01, later serotyped as Vibrio cholerae 0139. Forty-one of a total of 391 patients with acute diarrhoea during a 2-month period (May–July 1993) were identified as having Vibrio cholerae in faecal samples. All patients were aged 1.5–12 years. Vibrio cholerae 0139 was isolated in 30 patients (73%–group I) and Vibrio cholerae 01 biotype eltor in 11 patients (27%–group II). The clinical presentation and severity of the cholera-like illness were similar to typical cholera. This strain is toxigenic with an epidemic potential and should be monitored carefully □  相似文献   
78.
79.
80.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号