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51.
The radiological findings of ultrasound, CT and MR of a case of bilateral subacromial bursitis with macroscopic rice bodies is described. The previous literature is also reviewed. 相似文献
52.
RJH MASSIE PJ COOPER PP VAN ASPEREN & P McINTYRE 《Journal of paediatrics and child health》1998,34(5):477-479
Pneumocystis carinii pneumonia (PCP) occurs commonly in immunocompromised patients. Sulfamethoxazole-trimethoprim (SMX-TMP) is effective prophylaxis, although PCP may still occur despite apparently adequate use. We report three cases of PCP which highlight some of the pitfalls of prophylaxis. 相似文献
53.
A prospective study of 82 patients with acute renal failure was carried out over the last 2 years. Mean age of the patients was 35.6 years (8-82 years). Male to female ratio was 3.5:1. The etiological factors were septicaemia in 18 patients (21.95%), aminoglycoside toxicity in 16 patients (19.51%), open heart surgery in 8 patients (9.76%), volume depletion and blood loss in 12 patients (14.63%), glomerulonephritis in 4 patients (4.88%), renal allograft dysfunction in 4 patients (4.88%), and miscellaneous causes in 20 patients (24.39%). Non-oliguric renal failure was observed in 39.02 per cent cases. Dialysis support was required in 65.8 per cent of the cases; with average 5.6 (4 to 11) dialysis sessions. Four patients of acute renal failure following open heart surgery were given continuous arterio-venous haemofiltration. Overall mortality was 32.5 per cent, septicaemia accounting for 60 per cent of the deaths.KEYWORDS: Antibiotics, Aminoglycoside, Renal failure acute, Septicemia 相似文献
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外源性一氧化氮对创伤愈合过程中一氧化氮合酶表达及瘢痕形成的影响 总被引:5,自引:2,他引:5
目的:应用组织化学、免疫组织化学及计算机辅助图像分析方法,观察外源性一氧化氮在创伤愈合过程不同时间,对一氧化氮合酶表达和胶原形成的影响,探讨其在促进创伤愈合和抑制病理性瘢痕形成中的机制。方法:实验于2004-09/2006-03在河北省人民医院整形烧伤外科及河北省人民医院临床医学研究中心完成。以硝普钠为一氧化氮供体,将60只大鼠随机分为对照组及硝普钠0.5,1,2,4mmol/L组,每组12只,通过建立大鼠创伤模型,并分别在创面局部应用50g/L葡萄糖溶液、0.5,1,2,4mmol/L硝普钠,观察及测量创伤后3,7,10,14d的肉芽组织生长情况、一氧化氮合酶的表达情况和肉芽组织中羟脯氨酸含量。结果:60只大鼠全部进入结果分析。①形态学观察:对照组于创伤后14d可完全愈合;硝普钠0.5mmoL/L组及1mmoL/L组肉芽组织生长良好,且愈合时间较对照组提前三四天;硝普钠2mmoL/L组及4mmoL/L组愈合情况不良,完全愈合时间延迟,皮肤张力较低,炎症反应明显。②一氧化氮合酶蛋白表达:大鼠皮肤创伤后角质形成细胞、汗腺、毛囊和骨骼肌细胞以及创伤后肉芽组织的炎症细胞、成纤维细胞、血管内皮细胞均不同程度的表达一氧化氮合酶蛋白。对照组在第3天和第14天分别呈现一氧化氮合酶阳性颗粒表达高峰,而硝普钠各组仅在第7~10天出现表达一氧化氮合酶阳性高峰,呈先增加后减少的趋势。③羟脯氨酸含量:对照组从创伤后第3,7,10,14天羟脯氨酸含量进行性增加[依次为(1.637±0.127),(2.250±0.169),(2.420±0.201),(2.908±0.241)mg/g];硝普钠0.5mmol/L组在创伤后第3,7天羟脯氨酸含量低于对照组[(1.435±0.147),(1.766±0.211)mg/g,P<0.05或P<0.01],而在第10天和第14天羟脯氨酸含量均高于对照组[(3.128±0.240),(3.437±0.239)mg/g,P<0.01];硝普钠1mmol/L组和2mmol/L组在第10天和第14天的羟脯氨酸含量明显高于对照组[(1mmol/L组:(3.244±0.245)(3.582±0.282)mg/g,P<0.01;硝普钠2mmol/L组:(3.666±0.263),(4.301±0.268)mg/g,P<0.01);硝普钠4mmol/L组仅在创伤后第3天表现比对照组多[(1.912±0.139)mg/g,P<0.01),其余均与对照组水平相近。结论:局部应用外源性一氧化氮具有显著的促修复作用,主要体现在伤后第7~10天,小剂量的一氧化氮促进创面愈合的作用远远大于大剂量一氧化氮。 相似文献
58.
Giuseppe Calcaterra Pier P. Bassareo Francesco Barill Domenico Sergi Marcello Chiocchi Francesco Romeo Jawahar L. Mehta 《Current Cardiology Reviews》2021,17(1):74
Since its outbreak in China at the end of 2019, the new coronavirus disease (COVID-19) was characterized by both easy spreading and high mortality. The latter proved to be way more elevated in the North of Italy -with a peak of 18.4% in region Lombardia and even 31% in the city of Bergamo and surrounding county- than in the rest of the world. In an attempt to conceptualize the reasons for such a dramatic situation, four key elements have been identified: COVID-19 itself, old age, lung disease, and heart failure. Their harmful combination has been named “The deadly quartet”. The underlying risk factors, among which a lot of them are distinctive features of the population in northern Italy, have been summarized as “unmodifiable”, “partially modifiable”, and “modifiable”, for the sake of clarity. Up-to-date scientific evidence in this field has been described in the form of a narrative and easy-to-read review. 相似文献
59.
Nucleus accumbens shell and core dopamine responsiveness to sucrose in rats: role of response contingency and discriminative/conditioned cues 下载免费PDF全文
V. Bassareo F. Cucca P. Musio D. Lecca R. Frau G. Di Chiara 《The European journal of neuroscience》2015,41(6):802-809
This study investigated by microdialysis the role of response contingency and food‐associated cues in the responsiveness of dopamine transmission in the nucleus accumbens shell and core to sucrose feeding. In naive rats, single‐trial non‐contingent presentation and feeding of sucrose pellets increased dialysate shell dopamine and induced full habituation of dopamine responsiveness to sucrose feeding 24 and 48 h later. In rats trained to respond for sucrose pellets on a fixed ratio 1 (FR1) schedule, dialysate dopamine increased in the shell but not in the core during active responding as well as under extinction in the presence of sucrose cues. In rats yoked to the operant rats, the presentation of sucrose cues also increased dialysate dopamine selectively in the shell. In contrast, non‐contingent sucrose presentation and feeding in FR1‐trained and in yoked rats increased dialysate dopamine to a similar extent in the shell and core. It is concluded that, whereas non‐contingent sucrose feeding activated dopamine transmission in the shell and core, response‐contingent feeding activated, without habituation, dopamine transmission selectively in the shell as a result of the action of sucrose conditioned cues. These observations are consistent with a critical role of conditioned cues acquired during training and differential activation of shell vs. core dopamine for response‐contingent sucrose feeding. 相似文献
60.
Dolhain RJ; Tak PP; Dijkmans BA; De Kuiper P; Breedveld FC; Miltenburg AM 《Rheumatology (Oxford, England)》1998,37(5):502-508
Methotrexate (MTX) is one of the most widely prescribed drugs in the
treatment of rheumatoid arthritis (RA). The mechanism by which MTX exerts
its anti-rheumatic effect has not yet been defined. The aim of the present
study was to investigate the effect of MTX treatment (7.5- 15 mg/week) on
synovial tissue in RA. For this purpose, synovial biopsies were taken from
11 RA patients before and 16 weeks after initiation of MTX therapy.
Immunohistochemistry was performed using monoclonal antibodies (MAb)
specific for CD3, CD4, CD8, CD22, CD25, CD38, CD68, MAb67, Ki67, interferon
gamma (IFN-gamma), interleukin (IL)- 1alpha, IL-1beta, tumour necrosis
factor alpha (TNF-alpha), E-selectin, ICAM-1 and VCAM-1. All parameters for
disease activity improved during the period of treatment.
Immunohistochemical analysis revealed a statistically significant decrease
in scores for CD3, CD8, CD38, CD68, Ki67, IL-1beta, TNF-alpha and the
adhesion molecules E-selectin and VCAM-1. The observed decrease in synovial
scores for inflammatory cells, monokines and adhesion molecules suggests
that the anti- inflammatory effect of MTX is, in part, dependent on a
reduction in monokine-inducible vascular adhesion molecules and subsequent
reduction of cell traffic into joints.
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