Comparison of Tc-99m MAA Planar Versus SPECT/CT Imaging for Lung Shunt Fraction Evaluation Prior to Y-90 Radioembolization: Are We Overestimating Lung Shunt Fraction?

CardioVascular and Interventional Radiology - To compare lung shunt fraction (LSF) prior to Y-90 radioembolization calculated using planar imaging versus SPECT/CT in patients with hepatocellular...     

Panniculectomy after bariatric surgical weight loss: Analysis of complications and modifiable risk factors

Introduction

Bariatric surgery results in massive weight loss, leaving many patients with redundant skin that can cause significant physical and psychosocial limitations. We sought to identify variables associated with postoperative complications and adjuncts associated with the mitigation of postoperative complications.

Effects of monoclonal antibody therapy in patients with chronic lymphocytic leukemia

A phase I clinical trial was initiated to treat patients with stage IV B-derived chronic lymphocytic leukemia (CLL) with the IgG2a murine monoclonal antibody T101. This antibody binds to a 65,000-mol wt (T65) antigen found on normal T lymphocytes, malignant T lymphocytes, and B- derived CLL cells. All of the patients had a histologically confirmed diagnosis of advanced B-derived CLL and were refractory to standard therapy, and more than 50% of their leukemia cells reacted with the T101 antibody in vitro. The patients received T101 antibody two times per week, over two to 50 hours by intravenous administration in 100 mL of normal saline containing 5% human albumin. Twelve patients were treated with a fixed dosage of 1, 10, 50, or 100 mg, and one patient was treated with 140 mg of antibody. It was demonstrated that patients given two-hour infusions of 50 mg developed pulmonary toxicity, with shortness of breath and chest tightness. This toxicity was eliminated when infusions of 50 or 100 mg of T101 were prolonged to 50 hours. All dose levels caused a rapid but transient decrease in circulating leukemia cell counts. In vivo binding to circulating and bone marrow leukemia cells was demonstrated at all dose levels with increased binding at higher dosages. Antimurine antibody responses were not demonstrated in any patients at any time during treatment. Circulating free murine antibody was demonstrated in the serum of only the two patients treated with 100 mg of antibody as a 50-hour infusion and the patient treated with 140 mg of antibody over 30 hours. Antigenic modulation was demonstrated in patients treated at all dose levels but was particularly apparent in patients treated with prolonged infusions of 50 and 100 mg of antibody. We were also able to demonstrate antigenic modulation in lymph node cells, which strongly suggests in vivo labeling of these cells. Overall, T101 antibody alone appears to have a very limited therapeutic value for patients with CLL. The observations of in vivo labeling of tumor cells, antigenic modulation, antibody pharmacokinetics, toxicity, and antimurine antibody formation may be used in the future for more effective therapy when drugs or toxins are conjugated to the antibody.     

新疆家畜蠕形蚤病病原研究

本文详细介绍了在新疆发现的花蠕形蚤、叶氏蠕形蚤、北山羊蠕形蚤、羊长喙蚤和狍长喙蚤的形态学特点、地理分布和某些生物学特性。     

Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes

Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca²⁺ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca²⁺ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca²⁺ rise in pre-myelinating OLs, which is primarily mediated by Ca²⁺-permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K⁺ caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca²⁺ influx via P/Q- and L-type voltage-gated Ca²⁺ (Ca_v) channels. Thus, glutamate is a key signaling factor in dynamic communication between neurons and OLs that triggers Ca²⁺ transients via AMPARs and Ca_v channels in developing OLs. The results provide a mechanism for OL Ca²⁺ dynamics in response to neuronal input, which has implications for OL development and myelination.     

Angiodysplasia of the right colon treated by embolization with ivalon (polyvinyl alcohol)

Angiodysplasia of the colon is being recognized with increasing frequency as a source of lower gastrointestinal bleeding in the elderly. In one patient with colonic angiodysplasia, superselective segmental embolization of the ileo-colic artery with Ivalon resulted in the cessation of bleeding without causing bowel infarction. However, because of the development of collateral branches to the angiodysplastic malformation, bleeding recurred. While colectomy remains the treatment of choice in younger patients, in high risk patients embolization with a permanent embolic material, such as Ivalon, is an attractive alternative.     

带蒂腹直肌包绕阴茎增强犬尿道压力的研究

目的探讨采用带蒂腹直肌包绕球部尿道治疗男性尿失禁的可行性。方法成年雄性比格犬10条,游离阴茎周围组织,建立类似尿失禁模型。取长8．0cm,宽2．5cm全层带蒂的腹直肌。包绕球部尿道处阴茎1周。术前,术中,术后1个月、2个月分别测定尿道压力变化。结果术前平均最大尿道压力为(48．9±11．0)cm H_2O,使用带蒂腹直肌包绕阴茎后,平均最大尿道压力为(78．3±20．5)cmH_2O,与术前相比,差异有统计学意义(t=4．995,P＜0．01)。术后1个月和术后2个月复查时,平均最大尿道最大压力分别为(92．2±31．6)cm H_2O和(88．3±22．4)cm H_2O,与术前相比差异均有统计学意义(t=4．011,P＜0．01和t=6．058,P＜0．01)。结论采用带蒂腹直肌包绕球部尿道能明显提高尿道压力,为采用此法治疗男性尿失禁提供了实验依据。