全文获取类型
收费全文 | 2703篇 |
免费 | 150篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 235篇 |
妇产科学 | 53篇 |
基础医学 | 271篇 |
口腔科学 | 64篇 |
临床医学 | 185篇 |
内科学 | 530篇 |
皮肤病学 | 119篇 |
神经病学 | 117篇 |
特种医学 | 84篇 |
外科学 | 381篇 |
综合类 | 62篇 |
预防医学 | 136篇 |
眼科学 | 185篇 |
药学 | 262篇 |
中国医学 | 11篇 |
肿瘤学 | 145篇 |
出版年
2023年 | 24篇 |
2022年 | 57篇 |
2021年 | 97篇 |
2020年 | 55篇 |
2019年 | 65篇 |
2018年 | 81篇 |
2017年 | 86篇 |
2016年 | 95篇 |
2015年 | 83篇 |
2014年 | 132篇 |
2013年 | 159篇 |
2012年 | 196篇 |
2011年 | 186篇 |
2010年 | 108篇 |
2009年 | 90篇 |
2008年 | 149篇 |
2007年 | 127篇 |
2006年 | 122篇 |
2005年 | 104篇 |
2004年 | 92篇 |
2003年 | 63篇 |
2002年 | 51篇 |
2001年 | 47篇 |
2000年 | 48篇 |
1999年 | 38篇 |
1998年 | 21篇 |
1997年 | 23篇 |
1996年 | 10篇 |
1995年 | 17篇 |
1993年 | 16篇 |
1992年 | 41篇 |
1991年 | 24篇 |
1990年 | 34篇 |
1989年 | 33篇 |
1988年 | 34篇 |
1987年 | 26篇 |
1986年 | 20篇 |
1985年 | 28篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1980年 | 8篇 |
1979年 | 21篇 |
1978年 | 13篇 |
1977年 | 7篇 |
1975年 | 8篇 |
1974年 | 13篇 |
1973年 | 14篇 |
1972年 | 8篇 |
1971年 | 8篇 |
1965年 | 7篇 |
排序方式: 共有2861条查询结果,搜索用时 31 毫秒
11.
12.
13.
14.
Garima Chawla Piyush Gupta R Thilagavathi Asit K Chakraborti Arvind K Bansal 《European journal of pharmaceutical sciences》2003,20(3):305-317
This study deals with the generation and characterization of various solid-state forms of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor. The drug was subjected to polymorphic screen using different solvents to explore the possibility of existence of different solid forms. N,N-Dimethyl acetamide (DMA) and N,N-dimethyl formamide (DMF) yielded solvates in 1:1 stoichiometric ratio. Quench cooling of the melt resulted in amorphous form of the drug. All these solid-state forms were characterized by thermoanalytical (DSC, TGA, HSM), crystallographic (XRD), microscopic (polarized, SEM), spectroscopic (FTIR), and elemental analysis techniques. Solubility and van't Hoff studies were carried out for their thermodynamic interpretation. Influence of morphology of different solid-state forms on flow behavior was also investigated. Molecular modeling studies were used to elucidate the interaction between solute and solvent molecules in the solvate. 相似文献
15.
Himu P. Shukla Ralph P. Mason Navin Bansal Peter P. Antich 《Magnetic resonance in medicine》1996,35(6):827-833
A novel noninvasive method of measuring local myocardial oxygen tension (pO2) In the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions. 相似文献
16.
Anjali Ramaswamy Nina N. Brodsky Tomokazu S. Sumida Michela Comi Hiromitsu Asashima Kenneth B. Hoehn Ningshan Li Yunqing Liu Aagam Shah Neal G. Ravindra Jason Bishai Alamzeb Khan William Lau Brian Sellers Neha Bansal Pamela Guerrerio Avraham Unterman Victoria Habet Carrie L. Lucas 《Immunity》2021,54(5):1083-1095.e7
- Download : Download high-res image (177KB)
- Download : Download full-size image
17.
Mehta H Mahajan A Bansal N Vaidya S Pathak L 《The Journal of the Association of Physicians of India》1998,46(11):953-956
The above discussion on the interaction of aspirin and ACE inhibitors seems to suggest that aspirin in high doses may have adverse interaction with ACE inhibitors in patients with heart failure but the data obtained is not sufficient or conclusive to recommended omission of aspirin in patients with heart failure. This raises a query in the mind of the physician whether to use a combination or not? The role of aspirin in the early period after myocardial infarction is well established so is the role of ACE inhibitors. Hence in patients with myocardial infarction and preserved left ventricular function it would not be wrong to administer combination of ACE inhibitors and aspirin. Albeit at a lower dose. In patients with large myocardial infarction or heart failure, warfarin may be an option but still needs to be documented in large trials. As suggested long term use of aspirin after infarction is still ambiguous and may be harmful in patients with heart failure with its anticedent side effects. But long term benefits of ACE inhibitors in heart failure are well documented. Hence if a choice has to be made whether to discontinue either of the two drugs it would be preferable to stop the aspirin. To answer the issue of use of aspirin in patients with heart failure it would be essential to conduct a double blind randomized trial comparing known anti-thrombotic treatment, aspirin and anti-coagulants on mortality in patients with heart failure, especially caused by coronary artery disease. Such a trial is underway at the present and till the results are available it should be left to clinical judgement of the physician whether to administer aspirin in patients with heart failure after weighing the benefits versus risk. 相似文献
18.
Identification and DNA fingerprinting of Legionella strains by randomly amplified polymorphic DNA analysis. 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The randomly amplified polymorphic DNA (RAPD) technique was used in the development of a fingerprinting (typing) and identification protocol for Legionella strains. Twenty decamer random oligonucleotide primers were screened for their discriminatory abilities. Two candidate primers were selected. By using a combination of these primers, RAPD analysis allowed for the differentiation between all different species, between the serogroups, and further differentiation between subtypes of the same serogroup. The usefulness of RAPD analysis was also evaluated with outbreak-related clinical and environmental isolates previously typed by the restriction fragment length polymorphism technique. RAPD analysis proved to be as accurate as other genotypic methods, reproducible, and highly discriminatory and is a valuable new alternative to traditional fingerprinting and identification of Legionella species and strains. 相似文献
19.
Parmar RC Bavdekar SB Bansal S Doraiswamy A Khambadkone S 《Journal of postgraduate medicine》2000,46(2):91-93
Scleredema adultorum is a rare connective tissue disorder reported usually following streptococcal infection, influenza, measles, and mumps. It has been reported occasionally following trauma and tuberculous lymphadenitis. This is a report of scleredema adultorum developing after chicken pox in an eight-year-old male child. The diagnosis was established by characteristic picture on skin biopsy using special stain. The patient had a benign course and a spontaneous recovery in two weeks. The case has been reported as the first case of scleredema adultorum developing after chicken pox. 相似文献
20.
Studies on the development of an insulin resistant rat model by chronic feeding of low magnesium high sucrose diet. 总被引:1,自引:0,他引:1
Magnesium deficiency and excess sucrose in the diet have been shown to play an important role in the development of insulin resistance. In the present study we have looked at the combined effect of a low magnesium high sucrose diet on basal glucose and insulin levels, erythrocyte insulin receptors and lipid profile in rats. For this purpose rats were divided into four groups and fed control, low magnesium, high sucrose and low magnesium high sucrose diets respectively for three months. The biochemical analysis showed a significant increase in blood glucose and triglyceride levels after one, two and three months of feeding in both the high sucrose and the low magnesium high sucrose groups, while rats fed a low magnesium diet showed a significant increase in blood glucose and triglyceride levels only after the second month. Insulin levels increased significantly in low magnesium, high sucrose and low magnesium high sucrose groups by the end of the study period. Compared to control rats, the binding of insulin to the erythrocyte insulin receptors was reduced significantly in the high sucrose and the low magnesium high sucrose groups. Cholesterol levels were found to increase significantly in the high sucrose group at the end of one month and three months of feeding. HDL-cholesterol decreased significantly in the low magnesium high sucrose group by the end of the study. Serum and RBC magnesium levels demonstrated a significant decrease in the low magnesium and the low magnesium high sucrose groups. The post heparin plasma lipoprotein lipase activity was decreased significantly in low magnesium, high sucrose and low magnesium high sucrose groups compared to control rats. These findings suggest that feeding a diet low in magnesium and high in sucrose causes insulin resistance in rats. 相似文献