全文获取类型
收费全文 | 1957篇 |
免费 | 122篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 46篇 |
妇产科学 | 66篇 |
基础医学 | 208篇 |
口腔科学 | 46篇 |
临床医学 | 225篇 |
内科学 | 368篇 |
皮肤病学 | 60篇 |
神经病学 | 167篇 |
特种医学 | 74篇 |
外国民族医学 | 2篇 |
外科学 | 382篇 |
综合类 | 28篇 |
一般理论 | 2篇 |
预防医学 | 112篇 |
眼科学 | 44篇 |
药学 | 105篇 |
中国医学 | 11篇 |
肿瘤学 | 99篇 |
出版年
2024年 | 3篇 |
2023年 | 19篇 |
2022年 | 32篇 |
2021年 | 64篇 |
2020年 | 62篇 |
2019年 | 79篇 |
2018年 | 90篇 |
2017年 | 56篇 |
2016年 | 71篇 |
2015年 | 60篇 |
2014年 | 118篇 |
2013年 | 121篇 |
2012年 | 196篇 |
2011年 | 208篇 |
2010年 | 95篇 |
2009年 | 67篇 |
2008年 | 107篇 |
2007年 | 120篇 |
2006年 | 108篇 |
2005年 | 107篇 |
2004年 | 78篇 |
2003年 | 72篇 |
2002年 | 53篇 |
2001年 | 10篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1992年 | 1篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有2087条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
Maryam Nabati Safora Salehi Babak Bagheri Mahmoud Nouraei 《Journal of Echocardiography》2016,14(3):113-119
Objectives
The purpose of our study was to assess the echocardiographic and angiographic parameters in patients with symptomatic heart failure (HF) and mild diastolic dysfunction (grade I).Background
It remains uncertain why some patients with mild diastolic dysfunction exhibit HF symptoms and others are asymptomatic.Methods
The study enrolled 80 hospitalized patients with impaired left ventricular (LV) relaxation. Patients were divided into two groups; one group had chronic functional class II to III dyspnea and the other group had no symptoms of HF. After admission, echocardiography and coronary angiography were performed for all patients and LV systolic and diastolic parameters were compared between the two groups.Results
More patients in the asymptomatic group were hypertensive (p-value: 0.012). However, coronary artery disease was more prevalent in symptomatic patients (p-value: 0.022). The LV ejection fraction (EF) was significantly lower in symptomatic patients [median 54.33 %, 95 % confidence interval (53.76–54.87 %) in asymptomatic patients and median 49.43, 95 % confidence interval (47.23–50.91 %) in symptomatic patients, p-value <0.001]. Furthermore, the systolic LV internal dimension was significantly larger in this group (p-value: 0.037). The results of logistic regression identified that only the absolute level of the LVEF was the negative determinant of the occurrence of HF in patients with impaired LV relaxation.Conclusion
Our study showed that LV systolic performance has an important role in occurrence of HF symptoms in patients with grade I diastolic dysfunction.35.
Samip N. Patel MD Marc A. Cohen MD Babak Givi MD Benjamin J. Dixon MD Ralph W. Gilbert MD Patrick J. Gullane MD Dale H. Brown MD Jonathan C. Irish MSc MD John R. de Almeida MSc MD Kevin M. Higgins MSc Danny Enepekides MSc Shao Hui Huang John Waldron MD Brian O'Sullivan MD Wei Xu PhD Susie Su MSc David P. Goldstein MSc MD 《Head & neck》2016,38(Z1):E658-E664
36.
Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone 下载免费PDF全文
Stewart VA McGrath SM Dubois PM Pau MG Mettens P Shott J Cobb M Burge JR Larson D Ware LA Demoitie MA Weverling GJ Bayat B Custers JH Dubois MC Cohen J Goudsmit J Heppner DG 《Infection and immunity》2007,75(5):2283-2290
The RTS,S/AS02A protein-based vaccine consistently demonstrates significant protection against infection with Plasmodium falciparum malaria and also against clinical malaria and severe disease in children in areas of endemicity. Here we demonstrate with rhesus macaques that priming with a replication-defective human adenovirus serotype 35 (Ad35) vector encoding circumsporozoite protein (CS) (Ad35.CS), followed by boosting with RTS,S in an improved MPL- and QS21-based adjuvant formulation, AS01B, maintains antibody responses and dramatically increases levels of T cells producing gamma interferon and other Th1 cytokines in response to CS peptides. The increased T-cell responses induced by the combination of Ad35.CS and RTS,S/AS01B are sustained for at least 6 months postvaccination and may translate to improved and more durable protection against P. falciparum infection in humans. 相似文献
37.
Safdarian L Mohammadi FS Alleyassin A Aghahosseini M Meysamie A Rahimi E 《Human reproduction (Oxford, England)》2007,22(9):2449-2454
BACKGROUND: Traditional doses of depot GnRH agonist may be excessive for ovarian stimulation. We compared half-dose depot triptorelin (Group I) with reduced-dose daily buserelin (Group II) in a long protocol ICSI/embryo transfer through a double-blind randomized clinical trial. METHODS: Controlled ovarian stimulation (COS) was started by a pretreatment with oral contraceptives for 21 days. Then, 182 patients were randomized into two groups of 91. Group I received 1.87 mg triptorelin depot i.m. followed by daily s.c. injections of saline. Group II (reduced-dose protocol) received a bolus injection of i.m. saline followed by daily s.c. injections of 0.5 mg buserelin, which was then reduced to 0.25 mg at the start of human menopausal gonadotrophin stimulation. When transvaginal ultrasound showed at least two follicles of 16-20 mm diameter, HCG was given and ICSI was performed 40-42 h later. RESULTS: No significant differences were seen in the mean (SD) number of follicles at HCG administration, as our primary outcome [10.3 (4.4) in Group I versus 11.1 (4.2) in Group II, P = 0.180, mean difference = 0.86, 95% confidence interval 0.39-2.11]. The other early results of COS, clinical and ongoing pregnancy rates, or early pregnancy loss were also not significantly different between the groups. Group I endured longer stimulation period [11.2 (1.8) days versus 10.6 (1.9), P = 0.030]. CONCLUSIONS: Clinical outcomes were not significantly different between Group I and Group II. 相似文献
38.
Ali Yeganeh Mikaiel Hajializade Alireza Pahlevan Sabagh Babak Athari Mahbobeh Jamshidi Mehdi Moghtadaei 《World journal of orthopedics》2020,11(3):177-183
BACKGROUND Electrosurgical smoke could be different by the device of cutting or the type of tissue that is being cut.AIM To analyze the electrocautery smoke released from the tissues that are frequently cut in orthopedic surgeries.METHODS The released smoke from electrocautery of five different tissue types(meniscus,ligament,adipose,muscle,and synovium) of five patients who underwent total knee arthroplasty were collected and analyzed for volatile organic compounds(VOCs) and 27 candidate polycyclic aromatic hydrocarbons(n = 25).Surgical smoke was produced with an electrocautery device for 4 min.RESULTS None of the 27 evaluated polycyclic aromatic hydrocarbons compounds were detectable in electrocautery smoke collected from the surgical cutting of the different tissues.The number and identity of detected VOCs were similar between the patients but not between tissue types.The number of detected VOCs was the highest in synovial tissue(n = 21) and the lowest in the meniscus and adipose tissue(n = 12).The number of toxic and/or carcinogenic VOCs were the most in the muscle and meniscus tissues(Toluene,Ethylbenzene,and Styrene).No toxic and/or carcinogenic VOCs were identified in the ligament and adipose tissue.CONCLUSION Meniscus and muscle tissue are associated with the highest number of toxic and/or carcinogenic VOCs.Therefore,we recommend that surgeons avoiding the electrocautery of these tissues. 相似文献
39.
40.
Robert J. H. Miller Jacek Kwiecinski Kevin S. Shah Evann Eisenberg Jignesh Patel Jon A. Kobashigawa Babak Azarbal Balaji Tamarappoo Daniel S. Berman Piotr J. Slomka Evan Kransdorf Damini Dey 《American journal of transplantation》2020,20(5):1375-1383
Cardiac allograft vasculopathy (CAV) is an increasingly important complication after cardiac transplant. We assessed the additive diagnostic benefit of quantitative plaque analysis in patients undergoing coronary computed tomography–angiography (CCTA). Consecutive patients undergoing CCTA for CAV surveillance were identified. Scans were visually interpreted for coronary stenosis. Semiautomated software was used to quantify noncalcified plaque (NCP), as well as its components. Optimal diagnostic cut‐offs for CAV, with coronary angiography as gold standard, were defined using receiver operating characteristic curves. In total, 36 scans were identified in 17 patients. CAV was present in 17 (46.0%) reference coronary angiograms, at a median of 1.9 years before CCTA. Median NCP (147 vs 58, P < .001), low‐density NCP (median 4.5 vs 0.9, P = .003), fibrous plaque (median 76.1 vs 31.1, P = .003), and fibrofatty plaque (median 63.6 vs 27.6, P < .001) volumes were higher in patients with CAV, whereas calcified plaque was not (median 0.0 vs 0.0, P = .510). Visual assessment of CCTA alone was 70.6% sensitive and 100% specific for CAV. The addition of total NCP volume increased sensitivity to 82.4% while maintaining 100% specificity. NCP volume is significantly higher in patients with CAV. The addition of quantitative analysis to visual interpretation improves the sensitivity for detecting CAV without reducing specificity. 相似文献