Pilot study of ‘Feiji recipe’ in conjunction with chemotherapy on QoL in non‐small cell lung cancer patients. Larger controlled clinical trials are necessary to determine whether the Feiji recipe benefits overall non‐small cell lung cancer

Jian‐Hui Tian, Ling‐Shuang Liu, Zhi‐Ming Shi and Zhi‐Yi Zhou. A randomized controlled pilot trial of ‘Feiji recipe’ on quality of life on non‐small cell lung cancer patients. Am J Chin Med 2010; 38: 15–25.     

Peritoneo–scrotal communication: Demonstration by 99mtechnetium sulphur colloid scintigraphy

Continuous ambulatory peritoneal dialysis is a widely used and convenient alternative to haemodialysis in patients with renal failure. Occasionally, a scrotal swelling may develop during this procedure because of fluid passing through a patent processus vaginalis. We present a case report to illustrate the diagnostic use of radionuclide scintigraphy in this group of patients.     

Safety,tolerability, and efficacy of orally administered cannabinoids in MS

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.     

MEASUREMENT OF ROOT CANAL LENGTH – USE OF AN ELECTROMETRIC DEVICE

The measurement of root canal length is a pre-requisite for successful pulpectomy. The conventional manual and radiographic methods are not very accurate. In the present study, odontometer was used [Group B) to assess its efficacy over the conventional methods (Group A) for recording root canal length. In group A, 36 teeth were treated with pulpectomy while in group B, 51 teeth were managed by the same treatment. It was observed that post operative complications in group B were significantly less (p < 0.05). The odontometer proved to be an excellent device for rapid and accurate measurement of root canal length.KEY WORDS: Pulpectomy, Root canal length, Odontometer     

Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication

Individuals with the recessive condition trimethylaminuria exhibit variation in metabolic detoxication of xenobiotics by hepatic flavin- containing monooxygenases. We show here that mutations in the human flavin-containing monooxygenase isoform 3 gene ( FMO3 ) impair N - oxygenation of xenobiotics and are responsible for the trimethylaminuria phenotype. Three disease-causing mutations in nine Australian-born probands have been identified which share a particular polymorphic haplotype. Nonsense and missense mutations are associated with a severe phenotype and are also implicated in impaired metabolism of other nitrogen- and sulfur-containing substrates including biogenic amines, both clinically and when mutated proteins expressed from cDNA are studied in vitro . These findings illustrate the critical role played by human FMO3 in the metabolism of xenobiotic substrates and endogenous amines.      

紫外分光光度法测定背景未知的复方制剂组分

本文利用目标转换因子分析中具有使纯组分光谱可向自身逼近的性质,提出了一种迭代目标转换因子分析算法,用于寻找未知背景光谱.通过在复方扑热息痛注射液分析中的应用,扑热息痛和安替比林的平均回收率均为100.0％,变异系数分别为1.1％和1.0％。结果表明本法为含有未知背景的多组分体系的紫外分光光度分析提供了可行的途径。