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Ling SC Walters T McKiernan PJ Schwarz KB Garcia-Tsao G Shneider BL 《Journal of pediatric gastroenterology and nutrition》2011,52(3):254-261
Nonselective β-blocker therapy and endoscopic variceal ligation reduce the incidence of variceal hemorrhage in cirrhotic adults, but their use in children is controversial. There are no evidence-based recommendations for the prophylactic management of children at risk of variceal hemorrhage due to the lack of appropriate randomized controlled trials. In a recent gathering of experts at the American Association for the Study of Liver Diseases annual meeting, significant challenges were identified in attempting to design and implement a clinical trial of primary prophylaxis in children using either of these therapies. These challenges render such a trial unfeasible, primarily due to the large sample size required, inadequate knowledge of appropriate dosing of β-blockers, and difficulty in recruiting to a trial of endoscopic variceal ligation. Pediatric research should focus on addressing questions of natural history and diagnosis of varices, prediction of variceal bleeding, optimal approaches to β-blocker and ligation therapy, and alternative study designs to explore therapeutic efficacy in children. 相似文献
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Altstein AD Gitelman AK Smirnov YA Piskareva LM Zakharova LG Pashvykina GV Shmarov MM Zhirnov OP Varich NP Ilyinskii PO Shneider AM 《Archives of virology》2006,151(5):921-931
Summary. Two-fold immunization of Balb/c mice with a vaccinia virus recombinant expressing the NP protein of influenza A/PR8/34 (H1N1)
virus under the control of a strong synthetic promoter induced specific antibodies and protected animals against low-dose
challenge by mouse-adapted heterosubtypic variants of human A/Aichi2/68 (H3N2) and avian A/Mallard/Pennsylvania/10218/84 (H5N2)
influenza virus strains. The surviving immunized animals had lower anti-hemagglutinin antibody titers compared to non-immunized
mice. There was no difference in viral titers in lungs of immunized and non-immunized animals that succumbed to the infection.
In order to try to increase immune system presentation of NP-protein-derived peptides, and thereby increase their immunogenicity,
we constructed another vaccinia-based NP-expressing recombinant containing a rapid proteolysis signal covalently bound to
the NP protein. This sequence, derived from the mouse ornithine decarboxylase gene has been shown to increase degradation
of various proteins. However, we found that when used as part of a recombinant NP, this signal neither increased its proteolytic
degradation, nor was it more efficient in the induction of a protective response against influenza infection. 相似文献
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反相离子对-高效液相色谱法测定河豚毒素 总被引:9,自引:0,他引:9
目的建立了反相离子对-高效液相色谱法测定河豚毒素含量的方法。方法选用SHIMADZUODS色谱柱(150×6mm5μm),以0.2%(v/v)醋酸液为流动相,流速为1.2mL/min,检测波长为230nm。结果河豚毒素线性范围20~100μg/mL,r=0.9960(n=5);回收率为93.32%,RSD=5.41%(n=5);日内精密度为6.10%,日间精密度为7.42%(n=5)最低检测限50ng。结论方法准确、快速、简便,可作为迅速确定河豚毒素含量的测定方法。 相似文献
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