Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin

Chinese medicine has been used to treat a variety of cancer-related conditions. This study aims to examine the prevalence and patterns of Chinese medicine usage by cancer patients. We reviewed articles written in English and found only the Chinese medicine usage from the studies on complementary and alternative medicine (CAM). Seventy four (74) out of 81 articles reported rates of CAM usage ranging from 2.6 to 100%. Acupuncture was reported in 71 out of 81 studies. Other less commonly reported modalities included Qigong (n = 17), Chinese herbal medicine (n = 11), Taichi (n = 10), acupressure (n = 6), moxibustion (n = 2), Chinese dietary therapy (n = 1), Chinese massage (n = 1), cupping (n = 1) and other Chinese medicine modalities (n = 19). This review also found important limitations of the English language articles on CAM usage in cancer patients. Our results show that Chinese medicine, in particular Chinese herbal medicine, is commonly used by cancer patients. Further research is warranted to include studies not written in English.     

Myocardial post-conditioning with <Emphasis Type="Italic">Danshen-Gegen</Emphasis> decoction protects against isoproterenol-induced myocardial injury <Emphasis Type="Italic">via</Emphasis> a PKCε/mK<Subscript>ATP</Subscript>-mediated pathway in rats

Background  

Danshen-Gegen decoction (DG), a Chinese herbal formula, has been demonstrated to be effective for the treatment of coronary heart disease such as myocardial infarction. In the present study, we investigated the effect of DG post-conditioning on isoproterenol (ISO)-induced myocardial injury in rats.     

The transport of antiepileptic drugs by P-glycoprotein

Epilepsy is the most common serious chronic neurological disorder. Current data show that one-third of patients do not respond to anti-epileptic drugs (AEDs). Most non-responsive epilepsy patients are resistant to several, often all, AEDs, even though the drugs differ from each other in pharmacokinetics, mechanisms of action, and interaction potential. The mechanisms underlying drug resistance of epilepsy patients are still not clear. In recent years, one of the potential mechanisms interesting researchers is over-expression of P-glycoprotein (P-gp, also known as ABCB1 or MDR1) in endothelial cells of the blood-brain barrier (BBB) in epilepsy patients. P-gp plays a central role in drug absorption and distribution in many organisms. The expression of P-gp is greater in drug-resistant than in drug-responsive patients. Some studies also indicate that several AEDs are substrates or inhibitors of P-gp, implying that P-gp may play an important role in drug resistance in refractory epilepsy. In this article, we review the clinical and laboratory evidence that P-gp expression is increased in epileptic brain tissues and that AEDs are substrates of P-gp in vitro and in vivo. We discuss criteria for identifying the substrate status of AEDs and use structure-activity relationship (SAR) models to predict which AEDs act as P-gp substrates.     

Two new antimicrobial flavanes from dragon's blood of Dracaena cambodiana

Two new flavonoids, named cambodianins D (1) and E (2), together with two known flavanes (2S)-7,4'-dihydroxy-6,8-dimethylflavane (3) and (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (4), were isolated from dragon's blood of Dracaena cambodiana. The new compounds were determined by HR-ESI-MS and spectroscopic techniques (UV, IR, 1D, and 2D NMR). Compounds 1-3 exhibited antimicrobial activities.     

Two new meroterpenes from endophytic fungus A1 of Scyphiphora hydrophyllacea

Two new meroterpenes, guignardone D (1) and guignardone E (2), were isolated from endophytic fungus A1 of Scyphiphora hydrophyllacea Gaertn. F. Their structures were established based on spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and ROESY).     

心肌缺血下人体心室电生理建模和心电图仿真

为了分析心肌缺血下心肌细胞电生理变化以及对心室传导波的影响,本文考虑了缺血情况下高钾、酸液过多、局部缺氧的实际情况,开发了一个人体心室缺血模型。基于该模型,文中模拟了不同缺血程度下心内膜细胞、M细胞和心外膜细胞的动作电位(AP),并探讨了心肌缺血的三个单一因素分别对细胞AP的影响,最后定量分析了二维人体左心室组织心肌缺血下心电图(ECG)的改变情况。实验结果表明,在缺血情况下,心肌细胞动作电位时程(APD)均有不同程度的缩短。大多数情况下,缺血区域越大,或者缺血情况越严重,ECG的ST-T波变化幅度也越大。在上述三个心肌缺血因素中,高钾对ST-T波变化起到关键的作用,这与之前在动物模型上得到的实验结论保持一致。     

神经症患者生活事件与睡眠状况的相关研究

目的探讨神经症患者睡眠状况及生活事件的现状,并进一步研究患者的睡眠状况与生活事件的相关关系。方法在北京市某精神科专科医院选取神经症患者55名,采用生活事件量表（LES）和睡眠状况自评量表（SRSS）对其进行调查,分析神经症患者生活事件与睡眠状况之间的相关关系。结果①神经症患者的睡眠均分要显著高于常模（t=3.360,P〈0.01）;②高中以下文化程度与高中以上文化程度的神经症患者睡眠状况有显著差异（t=2.776,P〈0.01）;未婚的与已婚的神经症患者睡眠状况有显著差异（t=3.512,P〈0.01）;③不同性别、独生与否、婚姻状况的神经症患者所受的生活事件总刺激量并无显著差异（P〉0.05）;④不同类型神经症患者的生活事件与睡眠状况并无显著相关（r=0.041,P〉0.05）。结论①神经症患者比正常人出现更多的睡眠问题,睡眠质量比常人差;②高中以上文化程度的神经症患者的睡眠质量要优于高中以下文化程度的神经症患者;未婚的神经症患者的睡眠质量要优于已婚的神经症患者;③不同类型的神经症患者在经受了生活事件后,生活事件总刺激量对神经症患者的睡眠状况并无影响。     

中低频电疗加中药直流电导入治疗颈椎病的体会

目的通过中低频电疗并中药直流电导入治疗颈椎病,研究颈椎病的较佳疗法。方法采用中低频电疗与中药复方制剂直流电导入的综合治疗法,对6 000例颈椎病患者进行治疗观察,并以单纯中低频电疗法治疗颈椎病1 000例作对照,对两组的疗效进行评定,统计数据经χ2检验。结果综合治疗组治愈率为20%,总有效率为100%;对照组治愈率为9.3%,总有效率为97.3%。综合治疗组疗效明显优于对照组（χ2=461.3,P〈0.01）。结论中低频电疗加中药直流电导入综合疗法,可使颈椎病治疗效果显著提高,具有积极的临床应用及推广价值。