全文获取类型
收费全文 | 1604篇 |
免费 | 68篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 127篇 |
妇产科学 | 57篇 |
基础医学 | 133篇 |
口腔科学 | 100篇 |
临床医学 | 174篇 |
内科学 | 315篇 |
皮肤病学 | 69篇 |
神经病学 | 97篇 |
特种医学 | 77篇 |
外科学 | 237篇 |
综合类 | 24篇 |
预防医学 | 30篇 |
眼科学 | 33篇 |
药学 | 80篇 |
中国医学 | 3篇 |
肿瘤学 | 73篇 |
出版年
2024年 | 2篇 |
2023年 | 19篇 |
2022年 | 25篇 |
2021年 | 44篇 |
2020年 | 21篇 |
2019年 | 51篇 |
2018年 | 36篇 |
2017年 | 32篇 |
2016年 | 56篇 |
2015年 | 67篇 |
2014年 | 90篇 |
2013年 | 98篇 |
2012年 | 122篇 |
2011年 | 130篇 |
2010年 | 75篇 |
2009年 | 61篇 |
2008年 | 125篇 |
2007年 | 141篇 |
2006年 | 130篇 |
2005年 | 108篇 |
2004年 | 95篇 |
2003年 | 85篇 |
2002年 | 35篇 |
2001年 | 14篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有1683条查询结果,搜索用时 15 毫秒
61.
62.
Zuleyha Yildiz Arzu Ulu Armagan Incesulu Yalcin Ozkaptan Nejat Akar 《Clinical and applied thrombosis/hemostasis》2008,14(3):356-359
Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of .03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study. 相似文献
63.
INTRODUCTION: High plasma levels of sEPCR lead to dysfunction of the EPCR-mediated coagulation. We have evaluated the role of EPCR A3 haplotype with its representative promoter variant 1651 C-G in a total of twenty-seven pediatric stroke patients and fifty-nine healthy subjects. MATERIALS AND METHODS: Genotyping of the A3 haplotype was performed with RFLP analysis. Plasma sEPCR levels were measured with ELISA. The mutant 1651 G allele frequency was observed to be 0.166 in the patient group. Common risk factors such as FV 1691 G-A and PT 20210 G-A mutations were also screened. RESULTS AND CONCLUSIONS: None of the patients with sEPCR levels below 100 ng/ml carried the A3 haplotype, while patients with elevated sEPCR levels carried the A3 haplotype either in a heterozygous or homozygous state. Our study confirms that there is a strong association between A3 haplotype and elevated sEPCR levels. We suggest that elevated sEPCR levels might increase the risk of stroke at pediatric age when compared to controls. Studies with large series of patients are warranted to confirm this hypothesis. 相似文献
64.
Erkman Sanri Ebru Unal Akoglu Sinan Karacabey Ural Verimli Haldun Akoglu Umit Sehirli Arzu Denizbasi 《The American journal of emergency medicine》2018,36(11):1943-1946
Objectives
Confirmation of the endotracheal tube placement (CoETP) has the utmost importance in the management of an airway. Visualization of tracheal rings or carina with a fiber-optical bronchoscope (FOB) has considered to be a reliable method for the CoETP. However, FOB is expensive, time-consuming, and not always practical. Inexpensive endoscopic USB-cameras were shown to aid intubation successfully and reliably. On the other hand, there have been no studies investigating their use for the CoETP. Tracheal ultrasonography (TUS) is also a new, inexpensive and widely available alternative. A cadaver study has planned to evaluate the diagnostic utility of TUS and a USB-camera.Methods
This study was conducted in the Anatomy Lab of a University on a fresh frozen female cadaver. Three senior Emergency Physicians have intubated the cadaver, and performed TUS or USB-endoscopy. We have prepared a randomized intubation list (n = 96) in three blocks (3 times 32) as to include equal number of esophageal and tracheal intubations (48 for each). Each EP is performed all three interventions (intubation, TUS and USB-endoscopy) in consecutive blocks of 32 intubations, in turn. The position of the tube has been verified from a 2 cm wide ostium on the proximal trachea.Results
In this study, all intubations (n = 96, 100%) were correctly identified as tracheal or esophageal with both TUS and USB-camera. Both the sensitivity and specificity of TUS and USB-endoscopy for the CoETP were 100.0%.Conclusion
The perfect accuracy of TUS and USB-endoscopy, have placed those techniques in a unique position as an alternative in resource-poor situations. 相似文献65.
Does patient education increase antimuscarinic treatment persistence in overactive bladder syndrome? 下载免费PDF全文
Tulin Yildiz RN PhD Cenk M Yazici MD Cagri Dogan MD Muzeyyen Cetintas RN Arzu Malak RN 《International Journal of Urological Nursing》2015,9(2):84-91
Overactive bladder syndrome (OAB) is a chronic condition that requires long‐term management. Patient education may have role in decreasing the unfavourable effects of long‐term treatment of OAB. The aim of the study was to evaluate the effect of detailed patient education on the patients' persistence with antimuscarinic treatment for OAB. A total of 140 patients with the diagnosis of OAB were included in this study. Patients were randomly divided into two groups. Patients in Group 1 were given information by the same urology doctor about the disease and treatment. Patients in Group 2 were given information by a urology nurse. Patients were recalled in the first, third and sixth months of treatment. The treatment persistency was evaluated in the whole study population and between the groups. The persistency rates of the whole group were 88·6% in the first month, 65·7% in the third month and 45·7% in the sixth month. At the end of the sixth month, 42·8% of males and 47·1% of females were taking antimuscarinics (p = 0·580). The persistence rate of Groups 1 and 2 were 82·8 and 94·3% at the first month. (p = 0·034). It decreased to 31·4% in the first and 60% in the second group at the sixth month (p = 0·001). The persistence rate of antimuscarinic treatment is low. Patient education is simple and effective way of increasing persistence. Clinicians must pay attention to inform their patients about the disease and possible side effects of treatment. An educated health provider may be very helpful in educating patients for OAB. 相似文献
66.
67.
68.
Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the "broken egg" effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age- and sex-matched controls. Micronucleus frequency and the frequency of each of the NCs were significantly higher for wood workers than controls (P < 0.01). Cigarette smoking was associated with increased frequencies of micronuclei and NCs in the buccal mucosa epithelium cells of both the control and exposed groups. Our findings indicate that buccal cells of wood workers display increased levels of genotoxicity and toxicity, and that these biomarker responses may be related to the increased cancer risk among wood workers. 相似文献
69.
70.
Mandy G. Keijzer-Veen Arzu Dülger Friedo W. Dekker Jeroen Nauta Bert J. van der Heijden 《Pediatric nephrology (Berlin, Germany)》2010,25(3):509-516
Children born very prematurely who show intrauterine growth retardation (IUGR) are suggested to be at risk of developing high
blood pressure as adults. Renal function may already be impaired by young adult age. To study whether very preterm birth affects
blood pressure in young adults, we measured 24-h ambulatory blood pressure (Spacelabs™ 90207 device) and renin concentration
in 50 very premature individuals (<32 weeks of gestation), either small (SGA) or appropriate (AGA) for gestational age (21
SGA, 29 AGA), and 30 full-term controls who all were aged 20 years at time of measurement. The mean (standard deviation) daytime
systolic blood pressure in SGA and AGA prematurely born individuals, respectively, was 122.7 (8.7) and 123.1 (8.5) mmHg. These
values were, respectively, 3.6 mmHg [95% confidence interval (CI) −0.9 to 8.0] and 4.2 mmHg (95% CI 0.4−8.0) higher than in
controls [119.6 (7.6)]. Daytime diastolic blood pressure and nighttime blood pressure did not differ between groups. We conclude
that individuals born very preterm have higher daytime systolic blood pressure and higher risk of hypertension at a young
adult age. 相似文献