全文获取类型
收费全文 | 28646篇 |
免费 | 2027篇 |
国内免费 | 124篇 |
专业分类
耳鼻咽喉 | 265篇 |
儿科学 | 656篇 |
妇产科学 | 505篇 |
基础医学 | 3999篇 |
口腔科学 | 1829篇 |
临床医学 | 2799篇 |
内科学 | 6461篇 |
皮肤病学 | 570篇 |
神经病学 | 2646篇 |
特种医学 | 820篇 |
外科学 | 3457篇 |
综合类 | 344篇 |
一般理论 | 50篇 |
预防医学 | 2650篇 |
眼科学 | 699篇 |
药学 | 1672篇 |
中国医学 | 101篇 |
肿瘤学 | 1274篇 |
出版年
2023年 | 153篇 |
2022年 | 325篇 |
2021年 | 657篇 |
2020年 | 435篇 |
2019年 | 594篇 |
2018年 | 642篇 |
2017年 | 479篇 |
2016年 | 516篇 |
2015年 | 714篇 |
2014年 | 890篇 |
2013年 | 1389篇 |
2012年 | 1834篇 |
2011年 | 1887篇 |
2010年 | 1074篇 |
2009年 | 941篇 |
2008年 | 1494篇 |
2007年 | 1579篇 |
2006年 | 1577篇 |
2005年 | 1515篇 |
2004年 | 1418篇 |
2003年 | 1274篇 |
2002年 | 1309篇 |
2001年 | 366篇 |
2000年 | 277篇 |
1999年 | 334篇 |
1998年 | 293篇 |
1997年 | 265篇 |
1996年 | 243篇 |
1995年 | 205篇 |
1994年 | 187篇 |
1993年 | 202篇 |
1992年 | 202篇 |
1991年 | 180篇 |
1990年 | 171篇 |
1989年 | 176篇 |
1988年 | 148篇 |
1987年 | 160篇 |
1986年 | 138篇 |
1985年 | 173篇 |
1984年 | 211篇 |
1983年 | 175篇 |
1982年 | 224篇 |
1981年 | 212篇 |
1980年 | 213篇 |
1979年 | 136篇 |
1978年 | 144篇 |
1977年 | 142篇 |
1976年 | 150篇 |
1975年 | 149篇 |
1974年 | 126篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
David G Witte Michael E Brune Sweta P Katwala Ivan Milicic Deanne Stolarik Yu-Hua Hui Kennan C Marsh James F Kerwin Michael D Meyer Arthur A Hancock 《The Journal of pharmacology and experimental therapeutics》2002,300(2):495-504
Fiduxosin is a new alpha(1)-adrenoceptor antagonist targeted for the treatment of symptomatic benign prostatic hyperplasia. The purpose of this study was to determine and compare the potencies of the alpha(1)-adrenoceptor antagonists terazosin, doxazosin, tamsulosin, and fiduxosin, based on relationships between plasma drug concentrations and blockade of phenylephrine (PE)-induced intraurethral (IUP) and mean arterial pressure (MAP) responses after single oral dosing in conscious male beagle dogs. Magnitude of blockade and plasma concentrations were evaluated at selected time points over 24 h. All drugs produced dose-dependent antagonism of PE-induced IUP and MAP responses. When IUP and MAP blockade effects were plotted against drug plasma concentrations, direct relationships were observed that were well described by the sigmoidal maximal effect model. IUP IC(50) values for terazosin, doxazosin, tamsulosin, and fiduxosin were 48.6, 48.7, 0.42, and 261 ng/ml, respectively. MAP IC(50) values were 12.2, 13.8, 1.07, and 1904 ng/ml, respectively. Uroselectivity index values, defined as MAP IC(50)/IUP IC(50), were 0.25, 0.28, 2.6, and 7.3, respectively. These results extend previous observations with terazosin in this model, showing that doxazosin exhibits a uroselectivity index comparable to terazosin, consistent with the lack of alpha(1)-adrenoceptor subtype selectivity or uroselectivity of these drugs. Tamsulosin, an alpha(1a)-/alpha(1d)-subtype selective agent, had an index value approximately 10-fold greater than the nonselective drugs. Based on its pharmacokinetic profile and a relative uroselectivity 29-fold greater than the nonselective drugs, fiduxosin is expected to exhibit greater selectivity for urethral compared with vascular alpha(1)-adrenoceptors in human and should be a novel, long-acting, uroselective alpha(1)-adrenoceptor antagonist. 相似文献
72.
Andreia Coroas José G G de Oliveira Susana Sampaio Cátia Borges Isabel Tavares Manuel Pestana Maria D V de Almeida 《Journal of renal nutrition》2004,14(3):157-163
OBJECTIVE: Kidney transplantation restores renal filtration, although it does not achieve the function of 2 native kidneys, and with time it may involute back to chronic renal failure. We hypothesized that bioelectrical impedance analysis (BIA) might highlight differences for body compartments among kidney transplants (Tx) with different filtration rates. METHODS: Thirty transplantation patients (19 male, 11 female) were studied at 62.4+/-26.6 months postsurgery and were divided into 3 groups: good creatinine clearance (crCl, mL/min/1.73 m2; >65.0), borderline (35.0相似文献
73.
Paul D. Gittelman Joseph B. Jacobs Arthur S. Lebowitz Philip M. Tierno 《The Laryngoscope》1991,101(7):733-737
Toxic shock syndrome has been associated with rhinologic surgery and medical devices, and it has been linked to a circulating exotoxin of a toxogenic strain of Staphylococcus aureus. One hundred forty patients with rhinosinusitis were studied. Nasal cultures were obtained. The microbiological characteristics are described. The carrier rate for Staphylococcus aureus was 35%. Thirty percent of patients selected for surgery were Staphylococcus aureus carriers. Toxin-capable isolates were identified in 40% of those tested. Users of cocaine, topical decongestants, and steroid sprays had a statistically higher rate of Staphylococcus aureus carriage compared to non-users. It is hoped that by identifying the population at risk and defining the factors associated with the development of toxic shock syndrome, a cogent policy of prevention can be established. 相似文献
74.
Arthur A. Beisang III M.D. Robert A. Ersek M.D. F.A.C.S. 《Aesthetic plastic surgery》1992,16(1):83-90
The development of small, textured implant particles suspended in a hydrogel has allowed for subdermal injection therapy to fill tissue defects. The microimplant particles were placed subdermally into the ears of white New Zealand rabbits in order to characterize the foreign body response and the permanence of the implant. Serial micrometer readings were performed on the implant sites to determine any change in thickness of the augmentation following baseline measurement. An initial increase in the thickness was noted approximately 20–30 days postimplantation, as expected. A stable thickness was noted for the remainder of the experiment. Serial histological sections were performed at irregular intervals from one week to one year. Histology demonstrated a mild foreign body response with collagen surrounding each individual microimplant particle. The response was stable after 30–40 days and has remained stable for over one year. It was determined that the histology demonstrated a Boros IA type, or nonimmunogenic, low-turnover foreign body reaction. 相似文献
75.
Annette Jackson Cynthia McSherry Kim Butters Michael Diko P.Stephen Almond Arthur J Matas Nancy L Reinsmoen 《Human immunology》1997,55(2):148-153
Our previous studies have shown that the in vitro assay of donor antigen-specific hyporeactivity is a useful marker for identifying solid organ transplant recipients (kidney, lung and heart) at low risk for immunologic complications (i.e., late acute rejection episodes and chronic rejection). Donor antigen-specific hyporeactivity is defined as a significantly decreased post- vs. pretransplant proliferative response to donor antigens while response to third-party controls remains unchanged. We analyzed whether exposure to the same HLA-DR antigen pretransplant via random blood transfusion and posttransplant via the transplanted organ influenced the development of hyporeactivity. Thirty previously nontransfused recipients, each receiving two 150 ml pretransplant random blood transfusions, were assessed for hyporeactivity at 1 year posttransplant. Of the 12 recipients with pretransplant exposure to kidney HLA-DR via transfusions, 6 (50%) developed hyporesponsiveness; in contrast, of the 18 recipients who were not preexposed, only 3 (15%) exhibited this form of immunomodulation. Of interest, 2 of the 3 hyporesponsive recipients who were not preexposed, received units containing HLA-DR antigens previously shown to share crossreactive epitopes with the kidney HLA-DR. In conclusion, these results suggest a increased incidence in the development of hyporeactivity in patients receiving pretransplant transfusions which share an HLA-DR antigen with the transplanted kidney. 相似文献
76.
Social problem solving as a moderating variable between negative life stress and depressive symptoms
Arthur M. Nezu Christine M. Nezu Lisa Saraydarian Kathleen Kalmar George F. Ronan 《Cognitive therapy and research》1986,10(5):489-498
The present study sought to investigate the moderating function that social problem-solving effectiveness serves in relation to negative stressful life events and depressive symptomatology. It was also hypothesized that knowledge of problem solving would improve upon the prediction of level of depressive symptoms beyond the assessment of stressful events. Results involving 462 undergraduate students provide support for both predictions. Specifically, findings from a multiple regression analysis indicated that (1) differences in reported depressive mood between subjects under high and low stress levels were minimal for individuals characterized as effective problem-solvers, relative to those persons with problem-solving scores reflective of ineffective problem solving; and (2) assessment of problem-solving scores and their interaction with stress level provided for an additional three times the amount of explained variance in predicting depression scores beyond life stress scores. Additionally, a cross-validation of the regression analysis was conducted and found to result in a minimal amount of shrinkage that could be due to samplespecific characteristics.We would like to extend our appreciation to two anonymous reviewers for their helpful comments on an earlier draft of this article. The study was supported in part by a grant funded by Fairleigh Dickinson University to the first author. 相似文献
77.
S W Pyle B Morein J W Bess L Akerblom P L Nara S M Nigida N W Lerche W G Robey P J Fischinger L O Arthur 《Vaccine》1989,7(5):465-473
In mice, immunostimulatory complexes (ISCOMs) prepared from HIV-1 B external envelope glycoprotein (gp120) induced 10-fold higher antibody titres than gp120 emulsified in depot adjuvant, as measured by enzyme-linked immunosorbent assay (ELISA). Rhesus monkeys immunized with gp120 ISCOMs produced precipitating and virus neutralizing antibody titres equivalent to those seen in HIV-infected chimpanzees and humans. After multiple immunizations with HIV-1 B gp120 ISCOMs, a rhesus monkey developed a neutralizing response to the HIV-1 isolates RF and MN, but not to the CC isolate. Antisera from ISCOM-immunized rhesus monkeys recognized gp120 on the membranes of HIV-1 B-infected H9 cells, indicating the preservation of epitope structure in the ISCOMs matrix. 相似文献
78.
Abhay Vats Kristen Gillingham Arthur Matas Blanche Chavers 《American journal of transplantation》2002,2(10):939-945
We evaluated variables associated with improved late graft survival in 290 children transplanted between 11/1/1984 and 12/31/1997, and who had > 1 year graft survival. We studied the following variables: age, gender, race, primary disease (diseases prone to recurrence, i.e. hemolytic uremic syndrome, focal segmental glomerulosclerosis or oxalosis vs. others), primary vs. retransplant; donor source, acute tubular necrosis, acute rejection episodes in the first year, transplant era and discharge serum creatinine. Graft half-life was defined as the time taken for 1/2 of the grafts functioning at 1 year to fail. There were 205 living donor and 85 cadaveric transplant. The cumulative graft survival at 5 and 10 years was 88% and 75% for living donor, and 72% and 46% for cadaveric, respectively. Multivariate analyses showed a higher late graft survival to be associated with: no acute rejection episodes (risk ratio 0.16, p = 0.0001), age 2-5 years (risk ratio 0.24, p = 0.0007), living donor (risk ratio 0.46, p = 0.017), primary nonrecurrent disease (risk ratio 0.29, p = 0.001), Caucasian race (risk ratio 0.40, p = 0.006). A high half-life was seen with living donor transplant (21.3 years) and the age group 2-5 years (27.5 years). Further, living donor patients with no acute rejection episodes had the best half-life of 37.6 years, while children with hemolytic uremic syndrome, focal segmental glomerulosclerosis or oxalosis had the lowest overall half-life of 5.6 years. This study finds that living donor, no acute rejection episodes, age 2-5 years, Caucasian race and having a disease not prone to recurrence are strong predictors of late graft survival. Hence, preferential use of living donor and prevention of acute rejection episodes in the first year are key variables that can improve long-term renal graft survival in children. 相似文献
79.
80.
Fernando Regla Vargas Jos Carlos Cabral de Almeida Juan Clinton Llerena Dimas Fagundes Reis 《American journal of medical genetics. Part A》1992,44(6):716-719
We report on a boy with severe radial hypoplasia, absent thumbs and patellae, short stature, persistent diarrhea, slender nose and normal intelligence as another example of the RAPADILINO syndrome. © 1992 Wiley-Liss, Inc. 相似文献