全文获取类型
收费全文 | 2845篇 |
免费 | 208篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 63篇 |
妇产科学 | 76篇 |
基础医学 | 445篇 |
口腔科学 | 104篇 |
临床医学 | 206篇 |
内科学 | 755篇 |
皮肤病学 | 165篇 |
神经病学 | 248篇 |
特种医学 | 58篇 |
外科学 | 226篇 |
综合类 | 4篇 |
预防医学 | 148篇 |
眼科学 | 15篇 |
药学 | 243篇 |
中国医学 | 11篇 |
肿瘤学 | 296篇 |
出版年
2024年 | 2篇 |
2023年 | 37篇 |
2022年 | 68篇 |
2021年 | 125篇 |
2020年 | 81篇 |
2019年 | 117篇 |
2018年 | 105篇 |
2017年 | 93篇 |
2016年 | 85篇 |
2015年 | 112篇 |
2014年 | 145篇 |
2013年 | 142篇 |
2012年 | 235篇 |
2011年 | 262篇 |
2010年 | 128篇 |
2009年 | 133篇 |
2008年 | 204篇 |
2007年 | 171篇 |
2006年 | 162篇 |
2005年 | 176篇 |
2004年 | 153篇 |
2003年 | 124篇 |
2002年 | 92篇 |
2001年 | 9篇 |
2000年 | 10篇 |
1999年 | 13篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 8篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 4篇 |
1991年 | 7篇 |
1990年 | 8篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1977年 | 1篇 |
排序方式: 共有3086条查询结果,搜索用时 31 毫秒
131.
Quality of life in dependent older adults living at home 总被引:10,自引:0,他引:10
Fassino S Leombruni P Abbate Daga G Brustolin A Rovera GG Fabris F 《Archives of gerontology and geriatrics》2002,35(1):9-20
The purpose of medical interventions today is to favor the duration of life and to assure its quality. For a proper evaluation of the quality of life (QoL) of the elderly, it is important to assess not only the health status, but also psychological, functional and existential domains. Up to now, QoL of the dependent older living at home does not seem to have received sufficient attention. This study is a population based, cross-sectional health survey, and tries to give a picture of the QoL conditions of a group of dependent elderly living at home, using a specifically designed structured interview. In addition to this interview the Activities of Daily Living (ADL) Index and the Zung rating scale for Anxiety and Depression (AD) were administered to a total of 167 elderly (60 males and 107 females). The most interesting results of the study are the following: (1) the definition of dependence is often worsen by cultural prejudices; (2) psychopathological factors show a deep negative effect on 'attitudes towards life' of the dependent elderly; (3) QoL of the dependent elderly people in this sample is mainly negatively influenced by the degree of depression. We believe that the 'QoL-oriented' therapeutic strategy should consider more articulated and multidisciplinary geriatric and psychosocial interventions in this population. 相似文献
132.
Costantini M Tritto C Licci E Sticchi G Capone S Montinaro A Bruno A Nuzzaci G Picano E 《International journal of cardiology》2005,101(1):157-158
Acute myocarditis may mimic an infarction. Aim is to describe a case series of peculiar myocarditis. From 1997 to 2003, 11 male patients (age 17-39 years) were admitted with diagnosis of acute myocardial infarction, localized ST segment elevation and minimal enzyme release. Ten patients had fever in the 3 days prior to admission. Eight patients underwent coronary angiography showing normal coronary arteries. All remained asymptomatic at long term follow-up. In conclusion, myocarditis with ST elevation myocardial infarction presentation is an acute benign syndrome especially frequent in young males. 相似文献
133.
Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells 总被引:4,自引:0,他引:4
Annalisa Leardi Michele Caraglia Carmine Selleri Stefano Pepe Claudia Pizzi Rosario Notaro Antonietta Fabbrocini Sonya De Lorenzo Manuela MusicÒ Alberto Abbruzzese Angelo Raffaele Bianco & Pierosandro Tagliaferri 《British journal of haematology》1998,102(3):746-752
We investigated whether changes in iron metabolism and the transferrin receptor (TRF-R) expression were involved in the antileukaemic effects of arabinoside cytosine (ara-C). Treatment with 100 n M ara-C for 48 h reduced thymidine uptake and increased the surface expression of the TRF-R on leukaemic blasts derived from 13/16 (81%) patients and on the HL-60 and U-937 cell lines. Whereas intracellular non-haem iron was strongly depleted 24 h after ara-C addition, TRF-R up-regulation and recovery of intracellular non-haem iron concentration occurred together after a longer exposure of the cultured cells to the drug. Since iron is an essential regulator of cell proliferation we have evaluated the effects of the combination between ara-C and the iron chelator desferioxamine (DSF) on the growth of HL-60 and U-937 cells. We found that desferioxamine strongly potentiated the effects of ara-C on leukaemic cell growth inhibition and apoptosis. This is the first report of a positive interaction between ara-C and an iron chelator in terms of antileukaemic effects. 相似文献
134.
Palumbo R Gaetano C Antonini A Pompilio G Bracco E Rönnstrand L Heldin CH Capogrossi MC 《Arteriosclerosis, thrombosis, and vascular biology》2002,22(3):405-411
In the present study, we analyzed the effect of conditioned media (CM) from bovine aortic endothelial cells exposed to laminar shear stress (SS) of 5 dyne/cm2 (SS5) or 15 dyne/cm2 (SS15) for 16 hours on smooth muscle cell (SMC) migration. In response to CM from bovine aortic endothelial cells exposed to SS5 (CMSS5) and SS15 (CMSS15), migration was 45 +/- 5.5 and 30 +/- 1.5 cells per field, respectively (P<0.05). Similar results were obtained with SS of 2 versus 20 dyne/cm2 and also when SS of 5 and 15 dyne/cm2 lasted 24 hours. Platelet-derived growth factor (PDGF)-AA levels in CMSS5 and CMSS15 were 9 +/- 7 and 18 +/- 5 ng/10(6) cells for 16 hours, respectively (P<0.05); PDGF-BB levels in CMSS5 and CMSS15 were 38 +/- 10 and 53 +/- 10 ng/10(6) cells for 16 hours, respectively (P<0.05). PDGF receptor alpha (PDGFRalpha) and PDGF receptor beta (PDGFRbeta) in SMCs were phosphorylated by CMSS15>CMSS5. In response to CMSS15, a neutralizing antibody against PDGF-AA enhanced SMC migration to a level comparable to that of CMSS5; in contrast, antibodies against PDGF-BB abolished SMC migration. Transfection of SMCs with a dominant-negative PDGFRalpha or PDGFRbeta increased or inhibited, respectively, SMC migration in response to CMSS15. Overexpression of wild-type PDGFRalpha inhibited SMC migration in response to CMSS5, CMSS15, or recombinant PDGF-BB (P<0.001). These results suggest that the ability of high SS to inhibit arterial wall thickening in vivo may be related to enhanced activation of PDGFRalpha in SMCs by PDGF isoforms secreted by the endothelium. 相似文献
135.
Salvatore Petta Giada Sebastiani Elisabetta Bugianesi Mauro Viganò Vincent Wai-Sun Wong Annalisa Berzigotti Anna Ludovica Fracanzani Quentin M. Anstee Fabio Marra Marco Barbara Vincenza Calvaruso Calogero Cammà Vito Di Marco Antonio Craxì Victor de Ledinghen 《Journal of hepatology》2018,68(4):878-885
136.
137.
Celso Arrais Rodrigues Vanderson Rocha Peter Dreger Claudio Brunstein Henrik Sengeloev Jürgen Finke Mohamad Mohty Bernard Rio Eefke Petersen Fran?ois Guilhot Dietger Niederwieser Jan J. Cornelissen Pavel Jindra Arnon Nagler Nathalie Fegueux Hélène Schoemans Stephen Robinson Annalisa Ruggeri Eliane Gluckman Carmen Canals Anna Sureda 《Haematologica》2014,99(2):370-377
We have reported encouraging results of unrelated cord blood transplantation for patients with lymphoid malignancies. Whether those outcomes are comparable to matched unrelated donor transplants remains to be defined. We studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood (n=104) or mobilized peripheral blood stem cells (n=541) after a reduced-intensity conditioning regimen. Unrelated cord blood recipients had more refractory disease. Median follow-up time was 30 months. Neutrophil engraftment (81% vs. 97%, respectively; P<0.0001) and chronic graft-versus-host disease (26% vs. 52%; P=0.0005) were less frequent after unrelated cord blood than after matched unrelated donor, whereas no differences were observed in grade II–IV acute graft-versus-host disease (29% vs. 32%), non-relapse mortality (29% vs. 28%), and relapse or progression (28% vs. 35%) at 36 months. There were also no significant differences in 2-year progression-free survival (43% vs. 58%, respectively) and overall survival (36% vs. 51%) at 36 months. In a multivariate analysis, no differences were observed in the outcomes between the two stem cell sources except for a higher risk of neutrophil engraftment (hazard ratio=2.12; P<0.0001) and chronic graft-versus-host disease (hazard ratio 2.10; P=0.0002) after matched unrelated donor transplant. In conclusion, there was no difference in final outcomes after transplantation between umbilical cord blood and matched unrelated donor transplant. Umbilical cord blood is a valuable alternative for patients with lymphoid malignancies lacking an HLA-matched donor, being associated with lower risk of chronic graft-versus-host disease. 相似文献
138.
Annalisa Noce Raffaele Fabrini Mariarita Dessì Alessio Bocedi Silvia Santini Valentina Rovella Anna Pastore Manfredi Tesauro Sergio Bernardini Nicola Di Daniele Giorgio Ricci 《Acta diabetologica》2014,51(2):219-224
Erythrocyte glutathione transferase (e-GST) displays increased activity in patients with renal damage and positive correlation with homocysteine (Hcy) in patients under maintenance hemodialysis. Here, we determined e-GST, Hcy, and erythrocyte catalase (e-CAT) in 328 patients affected by type 2 diabetes mellitus (T2DM), 61 diabetic non-nephropathic patients and 267 affected by diabetes and by chronic kidney disease (CKD) under conservative therapy subdivided into four stages according to K-DOQI lines. e-GST activity was significantly higher in all T2DM patients compared to the control group (7.90 ± 0.26 vs. 5.6 ± 0.4 U/gHb), and we observed an enhanced activity in all subgroups of CKD diabetic patients. No significant correlation or increase has been found for e-CAT in all patients tested. Mean Hcy in diabetic patients is higher than that in healthy subjects (33.42 ± 1.23 vs. 13.6 ± 0.8 μM), and Hcy increases in relation to the CKD stage. As expected, a significant correlation was found between e-GST and Hcy levels. These findings suggest that e-GST hyperactivity is not caused directly by diabetes but by its consequent renal damage. e-GST, as well as Hcy, may represent an early biomarker of renal failure. 相似文献
139.
140.
Massimo Martino Mercedes Gori Giovanni Tripepi Anna Grazia Recchia Michele Cimminiello Pasquale Fabio Provenzano Virginia Naso Anna Ferreri Tiziana Moscato Giuseppe Console Barbara Loteta Giuseppe Alberto Gallo Massimo Gentile Vanessa Innao Marco Rossi Antonella Morabito Iolanda Donatella Vincelli Donato Mannina Annalisa Pitino 《Annals of hematology》2020,99(2):331-341
G-CSF administration after high-dose chemotherapy and autologous stem cell transplantation (ASCT) has been shown to expedite neutrophil recovery. Several studies comparing filgrastim and pegfilgrastim in the post-ASCT setting concluded that the two are at least equally effective. Lipegfilgrastim (LIP) is a new long-acting, once-per-cycle G-CSF. This multicentric, prospective study aimed to describe the use of LIP in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation (ASCT) and compare LIP with historic controls of patients who received short-acting agent (filgrastim [FIL]). Overall, 125 patients with a median age of 60 years received G-CSF after ASCT (80 patients LIP on day 1 post-ASCT and 45 patients FIL on day 5 post-ASCT). The median duration of grade 4 neutropenia (absolute neutrophil count [ANC] < 0.5 × 10 [9]/L) was 5 days in both LIP and FIL groups, whereas the median number of days to reach ANC ≥ 0.5 × 10 [9]/L was 10% lower in the LIP than in the FIL group (10 vs 11 days), respectively. Male sex was significantly associated with a faster ANC ≥ 0.5 × 10 [9] L response (p = 0.015). The incidence of FN was significantly lower in the LIP than in the FIL group (29% vs 49%, respectively, p = 0.024). The days to discharge after ASCT infusion were greater in patients with FN (p < 0.001). The study indicates that LIP had a shorter time to ANC recovery and is more effective than FIL for the prevention of FN in the ASCT setting. 相似文献