收费全文 | 10252篇 |
免费 | 736篇 |
国内免费 | 37篇 |
耳鼻咽喉 | 77篇 |
儿科学 | 293篇 |
妇产科学 | 293篇 |
基础医学 | 1380篇 |
口腔科学 | 233篇 |
临床医学 | 1274篇 |
内科学 | 2039篇 |
皮肤病学 | 259篇 |
神经病学 | 1081篇 |
特种医学 | 184篇 |
外科学 | 894篇 |
综合类 | 64篇 |
一般理论 | 16篇 |
预防医学 | 1306篇 |
眼科学 | 181篇 |
药学 | 682篇 |
中国医学 | 32篇 |
肿瘤学 | 737篇 |
2024年 | 16篇 |
2023年 | 132篇 |
2022年 | 225篇 |
2021年 | 462篇 |
2020年 | 263篇 |
2019年 | 360篇 |
2018年 | 375篇 |
2017年 | 274篇 |
2016年 | 314篇 |
2015年 | 316篇 |
2014年 | 393篇 |
2013年 | 580篇 |
2012年 | 829篇 |
2011年 | 821篇 |
2010年 | 472篇 |
2009年 | 373篇 |
2008年 | 632篇 |
2007年 | 620篇 |
2006年 | 569篇 |
2005年 | 540篇 |
2004年 | 455篇 |
2003年 | 438篇 |
2002年 | 389篇 |
2001年 | 42篇 |
2000年 | 35篇 |
1999年 | 39篇 |
1998年 | 68篇 |
1997年 | 68篇 |
1996年 | 60篇 |
1995年 | 51篇 |
1994年 | 40篇 |
1993年 | 45篇 |
1992年 | 32篇 |
1991年 | 31篇 |
1990年 | 26篇 |
1989年 | 24篇 |
1988年 | 27篇 |
1987年 | 28篇 |
1986年 | 25篇 |
1985年 | 26篇 |
1984年 | 33篇 |
1983年 | 39篇 |
1982年 | 35篇 |
1981年 | 35篇 |
1980年 | 41篇 |
1979年 | 13篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1975年 | 14篇 |
1973年 | 15篇 |
Gastric fistulas, bleeding, and strictures are commonly reported after laparoscopic sleeve gastrectomy (LSG), that increase morbidity and hospital stay and may put the patient’s life at risk. We report our prospective evaluation of application of synthetic sealant, a modified cyanoacrylate (Glubran®2), on suture rime, associated with omentopexy, to identify results on LSG-related complications.
MethodsPatients were enrolled for LSG by two Bariatric Centers, with high-level activity volume. Intraoperative recorded parameters were: operative time, estimated intraoperative bleeding, conversion rate. We prospectively evaluated the presence of early complications after LSG during the follow up period. Overall complications were analyzed. Perioperative data and weight loss were also evaluated. A control group was identified for the study.
ResultsGroup A (treated with omentopexy with Glubran®2) included 96 cases. Control group included 90 consecutive patients. There were no differences among group in terms of age, sex and Body Mass Index (BMI). No patient was lost to follow-up for both groups. Overall complication rate was significantly reduced in Group A. Mean operative time and estimated bleeding did not differ from control group. We observed three postoperative leaks in Group B, while no case in Group A (not statistical significancy). We did not observe any mortality, neither reoperation. Weight loss of the cohort was similar among groups. In our series, no leaks occurred applying omentopexy with Glubran®2.
ConclusionOur experience of omentopexy with a modified cyanoacrylate sealant may lead to a standardized and reproducible approach that can be safeguard for long LSG-suture rime.
Trial registrationRetrospective registration on clinicaltrials.gov PRS, with TRN NCT03833232 (14/02/2019).
相似文献Areas covered: In this review, the evolution of the knowledge on INSTIs use in the clinical setting is reviewed, analyzed, and interpreted. Emphasis is placed on the properties possibly accounting for several superiority results achieved by INSTIs in non-inferiority designed comparative clinical trials, which led to their inclusion as first line options in all versions of HIV therapeutic guidelines.
Expert commentary: Some unprecedented clinical-pharmacological properties of INSTIs, such as their rapid and sustained action against HIV replication, the optimal tolerability and safety profile and a clinically proven robust genetic barrier are the main factors justifying the successful clinical use of INSTIs. Based on these unique features, novel INSTIs-based treatment modalities are being developed, including the reduction of antiretroviral regimens to two drugs only. 相似文献
Areas covered: This review summarizes and gives a critical overview of the ongoing Phase II trials investigating therapies for PSC.
Expert opinion: Several novel molecules have been developed and are currently under investigation for the treatment of PSC, including FTC, PPC and serous OC. The trend of novel targeted agents is one towards individualized, tailored therapy, based on the molecular and biological differences that characterize tumors that seem similar based solely on histological analysis. The task of developing new molecules is particularly difficult for PSC, given the recurrent development of new patterns of drug resistance. However, even if current research is focused towards identifying the best treatments for each woman with a molecularly defined disease, a deeper knowledge of the molecular biology and genetics underlying FTC and its relation as a precursor of PSC is needed. 相似文献