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91.
Kiyoshi Hashizume Kazuo Ichikawa Satoru Suzuki Teiji Takeda Keishi Yamauchi Mutsuhiro Kobayashi Xiao-Yun MA 《Journal of bone and mineral metabolism》1992,10(2):39-49
Calorie restriction is important in managing patients with maturity onset diabetes mellitus (NIDDM). The effect of such restriction
on calcium metabolism is not known. The objective of this study was to determine whether patients on calorie restricted diets
would show any modification of parathyroid hormone (PTH) and calcitonin (CTN).
The serum levels of PTH and CTN were measured by radioimmunoassays in 269 patients with NIDDM. The patients were divided into
two groups depending on the intake of calorie, and PTH and CTN were monitored for 2 years. Plasma levels of vitamin D were
measured by competitive protein binding assays before and after each program.
The level of PTH (520.8±266.0 pg/ml) (mean±S.D.) was significantly (P<0.01) higher in 109 diabetic patients whose calorie intake was restricted for 2 years (diet (D) group) as compared with that
(256.6±103.8 pg/ml) of 160 diabetic patients whose calorie intake was not restricted (non-diet (ND) group). The daily oral
calcium intake of the two groups did not differ significantly. We found no significant difference in the serum PTH level in
the ND groupVS. normal control subjects (248.8±98.4, N=78). The serum calcium concentration and the amount of calcium excreted in urine
were slightly but significantly (P<0.01) lower in the D than in the ND group. The rate of tubular reabsorption of phosphate (% TRP) was significantly lower
in the D group than that in the ND group (P<0.01). The serum CTN level was significantly (P<0.01) lower in the D group (33.9±11.3 pg/ml) than in the ND group (64.9±21.2 pg/ml) 2 years after each treatment. The plasma
1,25-(OH)2-vitamin D level was significantly (P<0.01) lower in the D group (22.2±6.6 pg/ml) than in the ND group (50.6±4.2 pg/ml). When
the restriction of calorie intake in the D group was canceled, their PTH levels decreased, which was accompanied by increase
in the 1,25-(OH)2-vitamin D levels, whereas their CTN levels were unchanged.
These observations suggested that a restricted calorie intake is a risk factor for secondary hyperparathyroidism as well as
for a low serum level of CTN in patients with NIDDM. 相似文献
92.
Adenoid cystic carcinoma of the trachea and main-stem bronchus. A clinical, histopathologic, and immunohistochemical study 总被引:1,自引:0,他引:1
H Nomori S Kaseda K Kobayashi T Ishihara N Yanai C Torikata 《The Journal of thoracic and cardiovascular surgery》1988,96(2):271-277
Twelve cases of adenoid cystic carcinoma of the trachea and main-stem bronchus were histologically analyzed, and the results were examined with reference to the growth pattern of the tumor and the prognosis. The tumors were histologically classified into tubular, cribriform, and solid subtypes. Three histologic grades were established: grade I, tumors with tubular and cribriform subtypes but without solid subtype; grade II, tumors with tubular and cribriform subtypes in which the solid subtype comprised less than 20% of the area; grade III, tumors in which the solid subtype comprised more than 20% of the area. Three gross infiltrating types were established: type I, entirely intraluminal; type II, predominantly intraluminal; type III, predominantly extraluminal. In most cases histologic grade correlated with gross tumor type; that is, grades, I, II, and III were grossly types I, II, and III, respectively. The tumors infiltrating along the tracheobronchial wall were of the tubular or cribriform subtype, but not of the solid subtype. In two patients who died of distant metastasis, the histologic studies revealed the solid subtype. Immunohistochemical analysis demonstrated that the tubular subtype was the most differentiated form and the solid subtype, the most undifferentiated form. The histologic subtype of adenoid cystic carcinoma of the tracheobronchial tree was an important factor in the growth pattern of the tumor and the prognosis. 相似文献
93.
94.
Y Iwasaki M Kinoshita T Kurihara K Ikeda K Takamiya T Shiojima N Tagaya T Kobayashi 《Neurology》1992,42(5):1125-1126
95.
96.
M Kobayashi A Koyama K Yamagata N Yamaguchi M Narita H Shigematsu 《Nihon Jinzo Gakkai shi》1992,34(1):47-56
The glomerular injuries in 129 cases of IgA nephropathy (IgA-N) were examined ultrastructurally with special reference to the glomerular basement membrane (GBM) deposits and capillary loop abnormalities, and the correlation between these findings and the clinicopathological data was analyzed. The following results were obtained. 1) The degree of daily excretion of urine protein (UP) and creatinine clearance (Ccr) revealed a significant correlation with the degree of mesangial hypercellularities and the frequency of segmental lesions. 2) All sites of GBM deposits, and discontinuity and/or splitting among the GBM abnormalities showed a significant relation to the severity of proliferation and segmental lesions. 3) The GBM deposits, discontinuity and splitting showed a significant relation to the degree of UP and Ccr. We speculate therefore that capillary loop deposits and/or capillary loop discontinuity and splitting could represent histological prognostic factors for an unfavorable outcome in IgA nephropathy. 相似文献
97.
98.
I Hisatome N Sasaki M Yamakawa M Kobayashi Y Tanaka H Kosaka A Yoshida H Kotake H Mashiba A Takeda 《Nephron》1992,61(2):196-199
Two patients with diabetes mellitus had persistent hypouricemia due to increased urate clearance; the degree of the apparent renal hypouricemia with uricosuria was quite mild. At the onset of diabetes, their serum urate levels were normal. Even after good diabetes control in both cases, hypouricemia continued. Based on the pharmacological evaluation in both patients, pyrazinamide administration could partially decrease urate clearance, however, suppression by pyrazinamide was less than in normal subjects, and probenecid increased urate clearance. These results suggest that the present cases had a renal abnormality affecting tubular presecretory reabsorption of urate, which might be due to diabetes mellitus. 相似文献
99.
K. Kobayashi N. Mukae Y. Matsunag M. Hotchi 《Burns : journal of the International Society for Burn Injuries》1990,16(6):414-417
This report gives details of an extensively burned patient who died of candidiasis. Retrospectively, by using the procedure of indirect immunoperoxidase staining, we measured the levels of antibody to candida in the stored patient's serum, collected from the time of admission to our hospital until death. Gradual increases in the antibody titres to candida were seen over the postburn period. The findings can be useful in diagnosing candidiasis. 相似文献
100.