全文获取类型
收费全文 | 34169篇 |
免费 | 1605篇 |
国内免费 | 149篇 |
专业分类
耳鼻咽喉 | 335篇 |
儿科学 | 758篇 |
妇产科学 | 406篇 |
基础医学 | 4440篇 |
口腔科学 | 866篇 |
临床医学 | 2196篇 |
内科学 | 9007篇 |
皮肤病学 | 555篇 |
神经病学 | 2522篇 |
特种医学 | 1192篇 |
外科学 | 6292篇 |
综合类 | 148篇 |
一般理论 | 3篇 |
预防医学 | 1041篇 |
眼科学 | 427篇 |
药学 | 2382篇 |
中国医学 | 100篇 |
肿瘤学 | 3253篇 |
出版年
2023年 | 186篇 |
2022年 | 317篇 |
2021年 | 587篇 |
2020年 | 311篇 |
2019年 | 437篇 |
2018年 | 518篇 |
2017年 | 468篇 |
2016年 | 505篇 |
2015年 | 514篇 |
2014年 | 713篇 |
2013年 | 914篇 |
2012年 | 1465篇 |
2011年 | 1524篇 |
2010年 | 894篇 |
2009年 | 775篇 |
2008年 | 1463篇 |
2007年 | 1633篇 |
2006年 | 1628篇 |
2005年 | 1736篇 |
2004年 | 1645篇 |
2003年 | 1636篇 |
2002年 | 1527篇 |
2001年 | 1209篇 |
2000年 | 1296篇 |
1999年 | 1139篇 |
1998年 | 478篇 |
1997年 | 363篇 |
1996年 | 361篇 |
1995年 | 337篇 |
1994年 | 284篇 |
1993年 | 289篇 |
1992年 | 806篇 |
1991年 | 737篇 |
1990年 | 713篇 |
1989年 | 760篇 |
1988年 | 664篇 |
1987年 | 626篇 |
1986年 | 565篇 |
1985年 | 535篇 |
1984年 | 358篇 |
1983年 | 308篇 |
1982年 | 161篇 |
1979年 | 268篇 |
1978年 | 195篇 |
1977年 | 168篇 |
1974年 | 167篇 |
1973年 | 172篇 |
1972年 | 175篇 |
1971年 | 159篇 |
1970年 | 158篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
51.
52.
53.
H Nakanishi T Monden H Morimoto T Kobayashi T Shimano T Mori 《British journal of cancer》1991,64(2):239-242
Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We performed a double staining of PFP+ cells with Leu11b/CD16, Leu2a/CD8, or Leu3a/CD4 and showed that PFP was produced by 9% of CD8+ cells and 18% of CD16+ cells but not by CD4+ cells. In 28 colorectal cancer tissues, PFP immunoreactivity was observed in the lymphocytes infiltrating to the tumour stroma. The PFP+ cells were most numerous in Dukes A and decreased in number according to the progression of tumours. The PFP+ cells in TIL exhibited the same phenotypes as those in PBL but the PFP+ cells were more numerous in CD8+ cells than in CD16+ cells at all stages. This study represents the first evidence that PFP is mainly secreted from CD8+ cells in tumour tissues. It is hypothesised that the decrease in the number of PFP+ cells in accordance with tumour progression may reflect the suppression of the hosts local immunity. 相似文献
54.
S Kobayashi 《Nihon Geka Gakkai zasshi》1987,88(6):715-726
Among the patients with liver cirrhosis (LC) who undergo the operation, the postoperative complications are not infrequent and sometimes prove fatal. The impaired hepatic function, especially the impaired reticuloendothelial system (RES) function, has been claimed to be a possible pathogenic factor for these complications. The present experimental and clinical studies were undertaken to investigate the RES function and the effect of preoperative OK-432 administration as an RES potentiator in LC. The results are as follows: 1) CCl4-induced LC rats were evaluated for RES global phagocytic function, Kupffer cell phagocytic function, plasma opsonic activity and plasma opsonic substances such as fibronectin, C3 and IgG. All parameters except IgG showed significant depression compared to those values in normal rats. However, the administration of OK-432 (0.1 KE/rat, ip) improved all these depressed parameters. The OK-432 administration also significantly improved the survival following panperitonitis in LC rats. 2) Among 18 LC patients with hepatocellular carcinoma undergoing partial hepatectomy, the RES global phagocytic function, plasma opsonic activity and plasma opsonic substances were evaluated. Same as the experimental study, all parameters except IgG were significantly depressed among the LC patients compared to those values in the patients with normal liver. However, the preoperative OK-432 administration (5 KE/day sc for 4 days) significantly improved these parameters and consequently decreased the postoperative complications. These results indicate that the preoperative RES activation by the OK-432 was effective and useful for the prevention of the postoperative complications in the LC patients. 相似文献
55.
56.
Masato Sasaki Seiya Hirai Masakazu Kawabe Takahiko Uesaka Kouichi Morioka Akio Ihaya Kuniyoshi Tanaka 《European journal of cardio-thoracic surgery》2005,27(2):307-312
OBJECTIVE: The baseball-diamond principle is generally used for trocar placement during video-assisted thoracic surgery; however, we are unable to treat all peripheral lung lesions using this principle. Therefore, we have developed another method for determining trocar placement based on a modification of the conventional principle. We have termed this method the triangle target principle. This report describes the instrument positioning that we now use for many video-assisted thoracic surgical procedures. METHODS: We position 3 trocars in an equilateral triangle, with the target lesion at the apex. One vertex of the base becomes the site of the first trocar placement for introduction of the thoracoscopic camera. Another vertex of the base becomes the site for the second trocar for forceps or the endoscopic stapler. The third trocar is for forceps and is inserted to create the vicinity of target lesion. Four types of the triangle target principle were developed according to sites of the target lesion. RESULTS: Between January 2000 and December 2002, we used this principle for 161 patients who underwent video-assisted thoracic surgery and all intrathoracic lesions were accessible except in 3 patients requiring intraoperative modifications. CONCLUSIONS: We conclude that video-assisted thoracic surgery by this principle is more effective and easier than the conventional principle to treat intrathoracic disease. 相似文献
57.
58.
K. Kim T. Mizunari N. Mizutani S. Kobayashi K. Takizawa H. Kamiyama Y. Murai A. Teramoto 《Acta neurochirurgica》2006,148(3):353-357
Summary We describe a giant aneurysm of the anterior communicating artery (ACoA) which was treated with a STA-RA graft-A3 bonnet bypass
and A3–A3 side-to-side anastomosis. A giant and partially thrombosed ACoA aneurysm was partially coated 3 years before his
current presentation, its gradual increase producing visual field disturbances. An A3–A3 side-to-side anastomosis and STA-RA
graft-A3 bonnet bypass were performed. The aneurysm was dissected, and the thrombus removed under transient parent-artery
occlusion. The aneurysmal neck was successfully clipped without encountering ischemic changes. This strategy may be useful
for treating giant or thrombosed aneurysms in the region of the ACoA. 相似文献
59.
Kenji Tsukada Shigeru Kobayashi Tatsuya Gotoh Naoki Asakage Masayuki Sekine Morio Sasaki Eiji Miyazaki Takahisa Suzuki Toshio Yamada Shu Hirai Shigetaka Yamazaki 《Digestive endoscopy》2006,18(1):55-58
A case of early gastric carcinoma accompanied by Dieulafoy ulcer is presented. The patient, a 26‐year‐old female, visited our emergency room with chief complaints of massive hematemesis and tarry stool. The initial endoscopic examination revealed a superficial depressed lesion with a faded color accompanied by a tiny ulcer with converging folds at the anterior wall of the middle gastric body. Although no active bleeding vessel was found at that time, the patient was admitted to our hospital for further check‐ups and treatment. On the 6th hospital day, she developed massive hematemesis resulting in shock. Urgent endoscopy, this time, disclosed an exposed bleeding vessel at the small ulcer floor previously mentioned, and endoscopic hemostasis was achieved. Since, however, a biopsy at initial examination from the surrounding depressed area proved carcinoma, a partial distal gastrectomy was subsequently carried out. Histological examination of the resected specimen confirmed the diagnosis of carcinoma limited to the mucosa and submucosa along with findings consistent with Dieulafoy ulcer. This is a rare case of combination of early cancer and Dieulafoy ulcer particularly in such a young patient. A review of the literature is also presented. 相似文献
60.
Kazuo Yamakawa Masashi Takanashi Masao Watanabe Noriyuki Nakamura Tomonori Kobayashi Masato Hasegawa Yoshikuni Mizuno Shigeki Tanaka Hideo Mori 《Neuropathology》2006,26(6):586-591
We report on a male patient with Pick disease who had shown severe white matter atrophy and dilatation of the lateral ventricle in the frontal lobe from an early stage. Upon admission to our hospital 2 years after disease onset, the patient showed apathy, and MRI revealed severe atrophy of the cortex and white matter of the frontal lobe. He died at age 74, 11 years after disease onset. Autopsy revealed severe atrophy of the frontal and temporal lobes, severe loss of white matter in the frontal lobe, dilatation of the lateral ventricles, and cortical thinning. Histopathological examination showed severe loss of myelinated fibers in the frontal white matter and severe neuronal loss with gliosis in the frontal and temporal cortices. Many Pick bodies were seen. Our patient had a rare case of Pick disease predominantly affecting the frontal lobe with severe involvement of the white matter from an early stage. This case suggests that myelinated fibers in the white matter as well as cerebral neurons are primarily affected in Pick disease. 相似文献